An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes

An application programming interface for CellNetAnalyzer

(2011) Steffen Klamt et al.   BIOSYSTEMS

Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer

(2011) Cédric Coulouarn et al.   CARCINOGENESIS

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

(2011) Mirco Castoldi et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of mammalian cell cycle progression in the regenerating liver

(2011) Anuradha Chauhan et al.   JOURNAL OF THEORETICAL BIOLOGY

Logic-Based Models for the Analysis of Cell Signaling Networks

(2010) Melody K. Morris et al.   BIOCHEMISTRY

Odefy -- From discrete to continuous models

(2010) Jan Krumsiek et al.   BMC BIOINFORMATICS

Proliferative Suppression by CDK4/6 Inhibition: Complex Function of the Retinoblastoma Pathway in Liver Tissue and Hepatoma Cells

(2010) Dayana B. Rivadeneira et al.   GASTROENTEROLOGY

Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status

(2010) Francesca Buontempo et al.   INVESTIGATIONAL NEW DRUGS

Computing Combinatorial Intervention Strategies and Failure Modes in Signaling Networks

(2010) Regina Samaga et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

A comprehensive molecular interaction map of the budding yeast cell cycle

(2010) Kazunari Kaizu et al.   Molecular Systems Biology

A comprehensive map of the mTOR signaling network

(2010) Etienne Caron et al.   Molecular Systems Biology

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

(2010) S Whittaker et al.   ONCOGENE

Liver Regeneration after Partial Hepatectomy

(2009) George K. Michalopoulos   AMERICAN JOURNAL OF PATHOLOGY

ProMoT: modular modeling for systems biology

(2009) Sebastian Mirschel et al.   BIOINFORMATICS

Logical modelling of regulatory networks with GINsim 2.3

(2009) A. Naldi et al.   BIOSYSTEMS

Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation

(2009) Roberta Alfieri et al.   BMC BIOINFORMATICS

Reconstruction and logical modeling of glucose repression signaling pathways in Saccharomyces cerevisiae

(2009) Tobias S Christensen et al.   BMC Systems Biology

Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance

(2009) Özgür Sahin et al.   BMC Systems Biology

Computational systems biology of the cell cycle

(2009) A. Csikasz-Nagy   BRIEFINGS IN BIOINFORMATICS

Positive-feedback loops in cell cycle progression

(2009) Joseph R. Pomerening   FEBS LETTERS

Logical analysis of the budding yeast cell cycle

(2009) D.J. Irons   JOURNAL OF THEORETICAL BIOLOGY

Logical modelling of cell cycle control in eukaryotes: a comparative study

(2009) Adrien Fauré et al.   Molecular BioSystems

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

(2009) William W Chen et al.   Molecular Systems Biology

Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

(2009) Julio Saez-Rodriguez et al.   Molecular Systems Biology

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle

(2009) C. Gerard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data

(2009) Regina Samaga et al.   PLoS Computational Biology

ON/OFF and Beyond - A Boolean Model of Apoptosis

(2009) Rebekka Schlatter et al.   PLoS Computational Biology

Flexible informatics for linking experimental data to mathematical models via DataRail

(2008) Julio Saez-Rodriguez et al.   BIOINFORMATICS

Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction

(2008) Raimo Franke et al.   BMC Systems Biology

Small-Molecule Inhibitors of PDK1

(2008) Christian Peifer et al.   ChemMedChem

Standardizing experimental protocols

(2008) Marcel Schilling et al.   CURRENT OPINION IN BIOTECHNOLOGY

p21 and p27: roles in carcinogenesis and drug resistance

(2008) Abde M. Abukhdeir et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Regulation of DNA synthesis in mouse embryonic stem cells by transforming growth factor-α: Involvement of the PI3-K/Akt and Notch/Wnt signaling pathways

(2008) Jung Sun Heo et al.   GROWTH FACTORS

A mesoscale model of G1/S phase transition in liver regeneration

(2008) Anuradha Chauhan et al.   JOURNAL OF THEORETICAL BIOLOGY

A comprehensive modular map of molecular interactions in RB/E2F pathway

(2008) Laurence Calzone et al.   Molecular Systems Biology

A bistable Rb–E2F switch underlies the restriction point

(2008) Guang Yao et al.   NATURE CELL BIOLOGY

Boolean Network Model Predicts Cell Cycle Sequence of Fission Yeast

(2008) Maria I. Davidich et al.   PLoS One

Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma

(2008) Yasunobu Matsuda   WORLD JOURNAL OF GASTROENTEROLOGY