In vitro model for DNA double-strand break repair analysis in breast cancer reveals cell type–specific associations with age and prognosis

Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy

(2015) Christine S. Walsh   GYNECOLOGIC ONCOLOGY

Epithelial-Mesenchymal Transition Phenotype Is Associated with Clinicopathological Factors That Indicate Aggressive Biological Behavior and Poor Clinical Outcomes in Invasive Breast Cancer

(2015) Young Kyung Bae et al.   Journal of Breast Cancer

Inherited Mutations in 17 Breast Cancer Susceptibility Genes Among a Large Triple-Negative Breast Cancer Cohort Unselected for Family History of Breast Cancer

(2015) Fergus J. Couch et al.   JOURNAL OF CLINICAL ONCOLOGY

Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk

(2015) Douglas F. Easton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients

(2015) K Obermeier et al.   ONCOGENE

Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype?

(2015) Fanny Le Du et al.   Oncotarget

Correction: High Throughput Measurement of γH2AX DSB Repair Kinetics in a Healthy Human Population

(2015) Preety M. Sharma et al.   PLoS One

BRCA1 Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development

(2014) F. Bai et al.   CANCER RESEARCH

Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53

(2014) Ivanildce Cristiane Ireno et al.   CARCINOGENESIS

Functional Ex Vivo Assay to Select Homologous Recombination-Deficient Breast Tumors for PARP Inhibitor Treatment

(2014) K. A. T. Naipal et al.   CLINICAL CANCER RESEARCH

Breast-Cancer Risk in Families with Mutations in PALB2

(2014) Antonis C. Antoniou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention

(2014) F. J. Couch et al.   SCIENCE

Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age

(2014) Amita Vaidya et al.   PLoS Genetics

The complex genetic landscape of familial breast cancer

(2013) Lorenzo Melchor et al.   HUMAN GENETICS

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/− with susceptibility versus C57BL/6-Trp53+/− mice with resistance to mammary tumors

(2013) M Böhringer et al.   ONCOGENE

Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal and Neoplastic Mammary Cells In Vitro Using Novel Real-Time Technology

(2013) Katharina Mandel et al.   PLoS One

Triple Negative Breast Cancers Have a Reduced Expression of DNA Repair Genes

(2013) Enilze Ribeiro et al.   PLoS One

Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells

(2012) Christian Garm et al.   AGING CELL

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

(2012) N. Mavaddat et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation

(2012) T. Popova et al.   CANCER RESEARCH

The power of DNA double-strand break (DSB) repair testing to predict breast cancer susceptibility

(2012) Marlen Keimling et al.   FASEB JOURNAL

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epithelial–mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact

(2011) Chiara Foroni et al.   CANCER TREATMENT REVIEWS

γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization

(2011) Markus Löbrich et al.   CELL CYCLE

Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways

(2011) Marlen Keimling et al.   FASEB JOURNAL

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

The role of homologous recombination in radiation-induced double-strand break repair

(2011) Penny A. Jeggo et al.   RADIOTHERAPY AND ONCOLOGY

Histone  H2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

(2010) C. E. Redon et al.   CLINICAL CANCER RESEARCH

A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer

(2010) M. Graeser et al.   CLINICAL CANCER RESEARCH

Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors

(2010) A. Mukhopadhyay et al.   CLINICAL CANCER RESEARCH

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

(2010) Alfons Meindl et al.   NATURE GENETICS

Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies

(2010) Fiona M. Blows et al.   PLOS MEDICINE

DNA double-strand break repair activities in mammary epithelial cells--influence of endogenous p53 variants

(2009) M. Keimling et al.   CARCINOGENESIS

The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type

(2009) Britta Weigelt et al.   JOURNAL OF PATHOLOGY

Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies

(2009) H. Willers et al.   MOLECULAR CANCER RESEARCH

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights

(2009) Larry H. Thompson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Predisposition to Breast Cancer: Past, Present, and Future

(2008) Clare Turnbull et al.   Annual Review of Genomics and Human Genetics

A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens

(2008) Marlen Keimling et al.   INTERNATIONAL JOURNAL OF CANCER

The emerging landscape of breast cancer susceptibility

(2007) Michael R Stratton et al.   NATURE GENETICS