The complex genetic landscape of familial breast cancer

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

(2013) Kyriaki Michailidou et al.   NATURE GENETICS

Whole Exome Sequencing Suggests Much of Non-BRCA1/BRCA2 Familial Breast Cancer Is Due to Moderate and Low Penetrance Susceptibility Alleles

(2013) Francisco Javier Gracia-Aznarez et al.   PLoS One

Mutational analysis of telomere genes in BRCA1/2-negative breast cancer families with very short telomeres

(2012) Kira Yanowsky et al.   BREAST CANCER RESEARCH AND TREATMENT

The Retinoblastoma Gene Undergoes Rearrangements inBRCA1-Deficient Basal-like Breast Cancer

(2012) Göran Jönsson et al.   CANCER RESEARCH

Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation

(2012) T. Popova et al.   CANCER RESEARCH

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases

(2012) Beatriz Martinez-Delgado et al.   JOURNAL OF MEDICAL GENETICS

Exome sequencing reveals a novel Fanconi group defined by XRCC2 mutation: Figure 1

(2012) Hanan E Shamseldin et al.   JOURNAL OF MEDICAL GENETICS

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

(2012) Rachael Natrajan et al.   JOURNAL OF PATHOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

(2012) Elise Ruark et al.   NATURE

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

(2012) Nick Orr et al.   NATURE GENETICS

Deregulated miRNAs in Hereditary Breast Cancer Revealed a Role for miR-30c in Regulating KRAS Oncogene

(2012) Miljana Tanic et al.   PLoS One

Evolutionary Pathways in BRCA1-Associated Breast Tumors

(2012) Filipe C. Martins et al.   Cancer Discovery

A non-BRCA1/2 hereditary breast cancer sub-group defined by aCGH profiling of genetically related patients

(2011) M. A. Didraga et al.   BREAST CANCER RESEARCH AND TREATMENT

Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway

(2011) Miljana Tanic et al.   BREAST CANCER RESEARCH AND TREATMENT

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Phenotype-Genotype Correlation in Familial Breast Cancer

(2011) Ana Cristina Vargas et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Inherited Mutations in Breast Cancer Genes—Risk and Response

(2011) Andrew Y. Shuen et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Germline mutations in RAD51D confer susceptibility to ovarian cancer

(2011) Chey Loveday et al.   NATURE GENETICS

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

(2011) Suhwan Chang et al.   NATURE MEDICINE

Functions and regulation of the APOBEC family of proteins

(2011) Harold C. Smith et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genetic Anticipation Is Associated with Telomere Shortening in Hereditary Breast Cancer

(2011) Beatriz Martinez-Delgado et al.   PLoS Genetics

Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH

(2010) Simon A. Joosse et al.   BREAST CANCER RESEARCH AND TREATMENT

CK8/18 expression, the basal phenotype, and family history in identifying BRCA1-associated breast cancer in the Ontario site of the Breast Cancer Family Registry

(2010) Anna Marie Mulligan et al.   CANCER

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

(2010) P. J. O'Donovan et al.   CARCINOGENESIS

BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

(2010) Gemma Molyneux et al.   Cell Stem Cell

Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors

(2010) Simon A. Joosse et al.   GENES CHROMOSOMES & CANCER

Familial concordance of breast cancer pathology as an indicator of genotype in multiple-case families

(2010) Rosemary L. Balleine et al.   GENES CHROMOSOMES & CANCER

Transcriptional characteristics of familial non-BRCA1/BRCA2 breast tumors

(2010) Ricardo Fernández-Ramires et al.   INTERNATIONAL JOURNAL OF CANCER

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

(2010) Alfons Meindl et al.   NATURE GENETICS

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

(2010) Sophie Badie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide Linkage Scan Reveals Three Putative Breast-Cancer-Susceptibility Loci

(2009) Juan Manuel Rosa-Rosa et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Subtypes of familial breast tumours revealed by expression and copy number profiling

(2009) Nic Waddell et al.   BREAST CANCER RESEARCH AND TREATMENT

Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors

(2009) Jeremy M. Arnold et al.   BREAST CANCER RESEARCH AND TREATMENT

Gene expression profiling integrated into network modelling reveals heterogeneity in the mechanisms of BRCA1 tumorigenesis

(2009) R Fernández-Ramires et al.   BRITISH JOURNAL OF CANCER

High Incidence of Protein-Truncating TP53 Mutations in BRCA1-Related Breast Cancer

(2009) H. Holstege et al.   CANCER RESEARCH

High Frequency of TP53 Mutation in BRCA1 and Sporadic Basal-like Carcinomas but not in BRCA1 Luminal Breast Tumors

(2009) E. Manie et al.   CANCER RESEARCH

The current structural and functional understanding of APOBEC deaminases

(2009) Ronda Bransteitter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage

(2009) Rahul D. Ballal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

(2009) Elgene Lim et al.   NATURE MEDICINE

Prediction of BRCA1-association in hereditary non-BRCA1/2 breast carcinomas with array-CGH

(2008) Simon A. Joosse et al.   BREAST CANCER RESEARCH AND TREATMENT

Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors

(2008) Anita L. Bane et al.   BREAST CANCER RESEARCH AND TREATMENT

An integrative hypothesis about the origin and development of sporadic and familial breast cancer subtypes

(2008) L. Melchor et al.   CARCINOGENESIS

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

(2008) Simon N Stacey et al.   NATURE GENETICS

The Molecular Pathology of Hereditary Breast Cancer

(2008) J. Palacios et al.   PATHOBIOLOGY

Histopathological features of ‘BRCAX’ familial breast cancers in the kConFab resource

(2008) Maurice Loughrey et al.   PATHOLOGY