Serum amyloid A and inflammasome activation: A link to breast cancer progression?

Hepatocytes direct the formation of a pro-metastatic niche in the liver

(2019) Jae W. Lee et al.   NATURE

TLR4 blockade using TAK-242 suppresses ovarian and breast cancer cells invasion through the inhibition of extracellular matrix degradation and epithelial-mesenchymal transition

(2019) Zahra Zandi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammasome inhibitors: promising therapeutic approaches against cancer

(2019) Shengchao Xu et al.   Journal of Hematology & Oncology

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

(2019) Nour Ershaid et al.   Nature Communications

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

IL-1 receptor antagonist controls transcriptional signature of inflammation in patients with metastatic breast cancer

(2018) Te-Chia Wu et al.   CANCER RESEARCH

High-density lipoprotein inhibits serum amyloid A-mediated reactive-oxygen species generation and NLRP3 inflammasome activation

(2018) Preetha Shridas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the NLRP3 inflammasome in cancer

(2018) Maryam Moossavi et al.   Molecular Cancer

Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy

(2018) Dev Karan   Frontiers in Immunology

The family of the interleukin-1 receptors

(2017) Diana Boraschi et al.   IMMUNOLOGICAL REVIEWS

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults

(2016) Mieke Buck et al.   CURRENT MEDICINAL CHEMISTRY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Damage-associated molecular patterns in cancer: a double-edged sword

(2016) C Hernandez et al.   ONCOGENE

Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells

(2016) YANLI WANG et al.   ONCOLOGY REPORTS

Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis

(2016) Mu Yang et al.   Oncotarget

IL-1 drives breast cancer growth and bone metastasis in vivo

(2016) Ingunn Holen et al.   Oncotarget

Toll-like receptor signaling in primary immune deficiencies

(2015) Paul J. Maglione et al.   Annals of the New York Academy of Sciences

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Serum amyloid A induces interleukin-1β secretion from keratinocytes via the NACHT, LRR and PYD domains-containing protein 3 inflammasome

(2015) N. Yu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-6 as a Therapeutic Target

(2015) J.-F. Rossi et al.   CLINICAL CANCER RESEARCH

FDA Approval: Siltuximab for the Treatment of Patients with Multicentric Castleman Disease

(2015) A. Deisseroth et al.   CLINICAL CANCER RESEARCH

K+Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+Signaling

(2015) Michael A. Katsnelson et al.   JOURNAL OF IMMUNOLOGY

TLRs: Linking inflammation and breast cancer

(2014) Khyati Bhatelia et al.   CELLULAR SIGNALLING

Different molecular profiles are associated with breast cancer cell homing compared with colonisation of bone: evidence using a novel bone-seeking cell line

(2014) Faith Nutter et al.   ENDOCRINE-RELATED CANCER

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis and are targets of metastasis-inducing S100A4

(2014) M T Hansen et al.   ONCOGENE

Aberrant Expression of Interleukin-1β and Inflammasome Activation in Human Malignant Gliomas

(2014) Leonid Tarassishin et al.   PLoS One

Toll-Like Receptor 4 Prompts Human Breast Cancer Cells Invasiveness via Lipopolysaccharide Stimulation and Is Overexpressed in Patients with Lymph Node Metastasis

(2014) Huan Yang et al.   PLoS One

TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells

(2013) Hongliang Fang et al.   Cellular & Molecular Immunology

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

(2013) Matthew D. Neal et al.   PLoS One

Interleukin-1β in innate inflammation, autophagy and immunity

(2013) Leo A.B. Joosten et al.   SEMINARS IN IMMUNOLOGY

Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer

(2013) A D'Anneo et al.   Cell Death & Disease

Canakinumab in patients with cryopyrin-associated periodic syndrome: an update for clinicians

(2013) Jasmin B. Kuemmerle-Deschner et al.   Therapeutic Advances in Musculoskeletal Disease

Regulation of interleukin 1α secretion by inflammasomes: Table 1

(2012) Amir S Yazdi et al.   ANNALS OF THE RHEUMATIC DISEASES

Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion

(2012) Huan Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition

(2011) Gali Soria et al.   BMC CANCER

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice

(2011) J. L. Ather et al.   JOURNAL OF IMMUNOLOGY

Regulation of interleukin-1 in acute brain injury

(2011) David Brough et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification and Validation of SAA as a Potential Lung Cancer Biomarker and its Involvement in Metastatic Pathogenesis of Lung Cancer

(2010) Hye-Jin Sung et al.   JOURNAL OF PROTEOME RESEARCH

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Toll-like receptor 2 mediates invasion via activating NF-κB in MDA-MB-231 breast cancer cells

(2009) Wenjie Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toll-like receptor expression in normal ovary and ovarian tumors

(2009) Mingfu Zhou et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interleukin-18 increases metastasis and immune escape of stomach cancer via the downregulation of CD70 and maintenance of CD44

(2009) J. S. Kang et al.   CARCINOGENESIS

Randomized Double-Blind Placebo-Controlled Trial of Thalidomide in Combination With Gemcitabine and Carboplatin in Advanced Non–Small-Cell Lung Cancer

(2009) Siow Ming Lee et al.   JOURNAL OF CLINICAL ONCOLOGY

TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer

(2009) M Szajnik et al.   ONCOGENE

How Location Governs Toll-Like Receptor Signaling

(2009) Akanksha Chaturvedi et al.   TRAFFIC

Serum amyloid A enhances plasminogen activation: Implication for a role in colon cancer

(2008) Amit Michaeli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum amyloid A: An acute-phase protein involved in tumour pathogenesis

(2008) E. Malle et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Is serum amyloid A an endogenous TLR4 agonist?

(2008) Silvana Sandri et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY