Illuminating the complexity of GPCR pathway selectivity – advances in biosensor development
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Illuminating the complexity of GPCR pathway selectivity – advances in biosensor development
Authors
Keywords
Biosensors, GPCR, Bias, BRET, Functional selectivity
Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 69, Issue -, Pages 142-149
Publisher
Elsevier BV
Online
2021-05-26
DOI
10.1016/j.sbi.2021.04.006
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Components of the G s signaling cascade exhibit distinct changes in mobility and membrane domain localization upon β 2 ‐adrenergic receptor activation
- (2020) Alexey Bondar et al. TRAFFIC
- TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
- (2020) Reid H. J. Olsen et al. Nature Chemical Biology
- Structural basis of Gs and Gi recognition by the human glucagon receptor
- (2020) Anna Qiao et al. SCIENCE
- Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design
- (2020) Marcin Maziarz et al. CELL
- Conformational Basis of G Protein-Coupled Receptor Signaling Versatility
- (2020) Laura M. Wingler et al. TRENDS IN CELL BIOLOGY
- Agonist-induced formation of unproductive receptor-G12complexes
- (2020) Najeah Okashah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling
- (2020) Wonjo Jang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bioluminescence resonance energy transfer–based imaging of protein–protein interactions in living cells
- (2019) Hiroyuki Kobayashi et al. Nature Protocols
- Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells
- (2018) Qingwen Wan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors
- (2018) Yoon Namkung et al. Science Signaling
- Functional selectivity of GPCR-directed drug action through location bias
- (2017) Roshanak Irannejad et al. Nature Chemical Biology
- A kinetic view of GPCR allostery and biased agonism
- (2017) J Robert Lane et al. Nature Chemical Biology
- GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
- (2016) Alex R.B. Thomsen et al. CELL
- Activated G Protein GαsSamples Multiple Endomembrane Compartments
- (2016) Brent R. Martin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the adenosine A2A receptor bound to an engineered G protein
- (2016) Byron Carpenter et al. NATURE
- Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET
- (2016) Yoon Namkung et al. Nature Communications
- Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors
- (2015) Ikuo Masuho et al. Science Signaling
- The experimental power of FR900359 to study Gq-regulated biological processes
- (2015) Ramona Schrage et al. Nature Communications
- Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors
- (2015) Ikuo Masuho et al. Science Signaling
- The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin
- (2014) Sylvain Armando et al. FASEB JOURNAL
- Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2
- (2014) Alexandre Beautrait et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development and Characterization of Pepducins as Gs-biased Allosteric Agonists
- (2014) Richard Carr et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein
- (2013) J. Quoyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- REV, A BRET-Based Sensor of ERK Activity
- (2013) Chanjuan Xu et al. Frontiers in Endocrinology
- Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
- (2012) Aude Saulière et al. Nature Chemical Biology
- Mutations in GNAL cause primary torsion dystonia
- (2012) Tania Fuchs et al. NATURE GENETICS
- Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes
- (2011) Marta Busnelli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Multiplexing of Multicolor Bioluminescence Resonance Energy Transfer
- (2010) Billy Breton et al. BIOPHYSICAL JOURNAL
- The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers
- (2009) Bettye Hollins et al. CELLULAR SIGNALLING
- Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands
- (2009) M. Leduc et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor
- (2008) L. S. Barak et al. MOLECULAR PHARMACOLOGY
- Functional complementation of high-efficiency resonance energy transfer: a new tool for the study of protein binding interactions in living cells
- (2007) Paola Molinari et al. BIOCHEMICAL JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search