New insights into B cells as antigen presenting cells

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases

(2020) Robin A. Welsh et al.   PLOS BIOLOGY

CD4+ T Cells in the Blood of MS Patients Respond to Predicted Epitopes From B cell Receptors Found in Spinal Fluid

(2020) Rune A. Høglund et al.   Frontiers in Immunology

The love and hate relationship of HLA-DM/DO in the selection of immunodominant epitopes

(2020) Robin A Welsh et al.   CURRENT OPINION IN IMMUNOLOGY

Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing

(2020) Xin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

(2020) Jun Siong Low et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structurally distinct endocytic pathways for B cell receptors in B lymphocytes

(2020) Aleah D. Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses

(2019) Fanghui Zhang et al.   IMMUNITY

Transcriptomes of antigen presenting cells in human thymus

(2019) Ingvild S. M. Gabrielsen et al.   PLoS One

Efficient T cell–B cell collaboration guides autoantibody epitope bias and onset of celiac disease

(2019) Rasmus Iversen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection

(2019) E. Nicole Arroyo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synergy between B cell receptor/antigen uptake and MHCII peptide editing relies on HLA-DO tuning

(2019) Wei Jiang et al.   Scientific Reports

B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells

(2019) Peter Csaba Huszthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

(2018) Marthe F.S. Lindenbergh et al.   Annual Review of Immunology

Follicular B Cells Promote Atherosclerosis via T Cell–Mediated Differentiation Into Plasma Cells and Secreting Pathogenic Immunoglobulin GHighlights

(2018) Christopher Tay et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD4+ T cell-mediated cytotoxicity is associated with MHC class II expression on malignant CD19+ B cells in diffuse large B cell lymphoma

(2018) Yong Zhou et al.   EXPERIMENTAL CELL RESEARCH

Role of B cells in T H cell responses in a mouse model of asthma

(2018) Tomasz Piotr Wypych et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

(2018) Patrique Praest et al.   MOLECULAR IMMUNOLOGY

The Impact of the CD9 Tetraspanin on Lentivirus Infectivity and Exosome Secretion

(2018) Kai O. Böker et al.   MOLECULAR THERAPY

Nonfollicular reactivation of bone marrow resident memory CD4 T cells in immune clusters of the bone marrow

(2018) Francesco Siracusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density

(2018) Chen-Hao Yeh et al.   Nature Communications

Expression and Function of Tetraspanins and Their Interacting Partners in B Cells

(2018) Fagui Zou et al.   Frontiers in Immunology

On the structure–function of MHC class II molecules and how single amino acid polymorphisms could alter intracellular trafficking

(2018) Jacques Thibodeau et al.   HUMAN IMMUNOLOGY

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

(2018) Sheng Hong et al.   IMMUNITY

Class II MHC antigen processing in immune tolerance and inflammation

(2018) Mollie M. Jurewicz et al.   IMMUNOGENETICS

HLA-DO modulates the diversity of the MHC-II self-peptidome

(2018) Padma P Nanaware et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of thymic B cells in the development of thymus-derived regulatory T cell in vitro

(2017) Haider H. Mohammed Ali et al.   IMMUNOLOGY LETTERS

B cells differentiate in human thymus and express AIRE

(2017) Vincent Gies et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

B cell–derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity

(2017) Tanvi Arkatkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments

(2017) Janna Schneppenheim et al.   JOURNAL OF IMMUNOLOGY

Antigen Acquisition Enables Newly Arriving B Cells To Enter Ongoing Immunization-Induced Germinal Centers

(2017) Jackson S. Turner et al.   JOURNAL OF IMMUNOLOGY

IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo

(2017) Vinayak Brahmakshatriya et al.   JOURNAL OF IMMUNOLOGY

CD9 Regulates Major Histocompatibility Complex Class II Trafficking in Monocyte-Derived Dendritic Cells

(2017) Vera Rocha-Perugini et al.   MOLECULAR AND CELLULAR BIOLOGY

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens

(2017) Michael S. Khodadoust et al.   NATURE

Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function

(2017) Peiwen Lu et al.   SCIENCE

Transiently antigen-primed B cells return to naive-like state in absence of T-cell help

(2017) Jackson S. Turner et al.   Nature Communications

The Other Function: Class II-Restricted Antigen Presentation by B Cells

(2017) Lital N. Adler et al.   Frontiers in Immunology

LAMP-2C Inhibits MHC Class II Presentation of Cytoplasmic Antigens by Disrupting Chaperone-Mediated Autophagy

(2016) Liliana Pérez et al.   JOURNAL OF IMMUNOLOGY

The Human Thymus Is Enriched for Autoreactive B Cells

(2016) Magdalena B. Rother et al.   JOURNAL OF IMMUNOLOGY

Transcriptional programs that control expression of the autoimmune regulator gene Aire

(2016) Yonatan Herzig et al.   NATURE IMMUNOLOGY

TFH cells progressively differentiate to regulate the germinal center response

(2016) Jason S Weinstein et al.   NATURE IMMUNOLOGY

Germinal center B cells recognize antigen through a specialized immune synapse architecture

(2016) Carla R Nowosad et al.   NATURE IMMUNOLOGY

Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung

(2016) Ji Young Hwang et al.   Frontiers in Immunology

Targeting B-cell malignancies through human B-cell receptor specific CD4+ T cells

(2016) Jinsheng Weng et al.   OncoImmunology

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

(2015) Tomoyoshi Yamano et al.   IMMUNITY

Antigen-B Cell Receptor Complexes Associate with Intracellular major histocompatibility complex (MHC) Class II Molecules

(2015) Margarida Barroso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B Cell Antigen Presentation Is Sufficient To Drive Neuroinflammation in an Animal Model of Multiple Sclerosis

(2015) Chelsea R. Parker Harp et al.   JOURNAL OF IMMUNOLOGY

B Cell–Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus

(2015) Josephine R. Giles et al.   JOURNAL OF IMMUNOLOGY

Killer B Lymphocytes and Their Fas Ligand Positive Exosomes as Inducers of Immune Tolerance

(2015) Steven K. Lundy et al.   Frontiers in Immunology

Development and Function of Protective and Pathologic Memory CD4 T Cells

(2015) Shafqat Ahrar Jaigirdar et al.   Frontiers in Immunology

Intraclonal Competition Inhibits the Formation of High-Affinity Antibody-Secreting Cells

(2014) T.-v. L. Le et al.   JOURNAL OF IMMUNOLOGY

The MHC Class II Cofactor HLA-DM Interacts with Ig in B Cells

(2014) Henriette Macmillan et al.   JOURNAL OF IMMUNOLOGY

B Cell Antigen Presentation in the Initiation of Follicular Helper T Cell and Germinal Center Differentiation

(2014) L. G. Barnett et al.   JOURNAL OF IMMUNOLOGY

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

Dynamic signaling by T follicular helper cells during germinal center B cell selection

(2014) Z. Shulman et al.   SCIENCE

Human B Cell-Derived Lymphoblastoid Cell Lines Constitutively Produce Fas Ligand and Secrete MHCII+FasL+ Killer Exosomes

(2014) Matthew W. Klinker et al.   Frontiers in Immunology

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

(2013) Nicolas Molnarfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lung niches for the generation and maintenance of tissue-resident memory T cells

(2013) D L Turner et al.   Mucosal Immunology

Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection

(2013) J. Perera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection

(2012) Wouter Pos et al.   CELL

The role of tetraspanin CD63 in antigen presentation via MHC class II

(2011) Sven H. Petersen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation

(2011) Maria-Isabel Yuseff et al.   IMMUNITY

Memory CD4 T Cells That Express CXCR5 Provide Accelerated Help to B Cells

(2011) M. K. L. MacLeod et al.   JOURNAL OF IMMUNOLOGY

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

TLR and B Cell Receptor Signals to B Cells Differentially Program Primary and Memory Th1 Responses to Salmonella enterica

(2010) T. A. Barr et al.   JOURNAL OF IMMUNOLOGY

H2-O, a MHC class II-like protein, sets a threshold for B-cell entry into germinal centers

(2010) N. A. Draghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus

(2009) Wojciech Wojciechowski et al.   IMMUNITY