Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo

Non-Invasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13 C MRI

(2020) Oliver J Rider et al.   CIRCULATION RESEARCH

Reconstruction of spectra from truncated free induction decays by deep learning in proton magnetic resonance spectroscopy

(2020) Hyochul Lee et al.   MAGNETIC RESONANCE IN MEDICINE

Glutamate-Weighted CEST Contrast After Removal of Magnetization Transfer Effect in Human Brain and Rat Brain with Tumor

(2020) Ayan Debnath et al.   MOLECULAR IMAGING AND BIOLOGY

Quantitative theory for the transverse relaxation time of blood water

(2020) Wenbo Li et al.   NMR IN BIOMEDICINE

Imaging breast cancer using hyperpolarized carbon-13 MRI

(2020) Ferdia A. Gallagher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetic resonance imaging of glycogen using its magnetic coupling with water

(2020) Yang Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo imaging of phosphocreatine with artificial neural networks

(2020) Lin Chen et al.   Nature Communications

Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

(2020) Lorena Consolino et al.   Frontiers in Oncology

1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo

(2020) Laurie J. Rich et al.   Nature Biomedical Engineering

Accelerating GluCEST imaging using deep learning for B 0 correction

(2020) Yiran Li et al.   MAGNETIC RESONANCE IN MEDICINE

Complementarity of gluCEST and 1 H-MRS for the study of mouse models of Huntington's disease

(2020) Jérémy Pépin et al.   NMR IN BIOMEDICINE

Spectroscopic measurements of metabolic fluxes

(2020) Peter C. M. van Zijl et al.   Nature Biomedical Engineering

Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases

(2020) Dengrong Jiang et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Validation of T 2 ‐based oxygen extraction fraction measurement with 15 O positron emission tomography

(2020) Dengrong Jiang et al.   MAGNETIC RESONANCE IN MEDICINE

Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer

(2020) Susana Ros et al.   CANCER CELL

Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla

(2020) Dushyant Kumar et al.   MAGNETIC RESONANCE IN MEDICINE

Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research

(2020) Joseph J. Shaffer et al.   Frontiers in Psychiatry

Frequency and phase correction of J‐difference edited MR spectra using deep learning

(2020) Sofie Tapper et al.   MAGNETIC RESONANCE IN MEDICINE

Incorporation of a spectral model in a convolutional neural network for accelerated spectral fitting

(2019) Saumya S. Gurbani et al.   MAGNETIC RESONANCE IN MEDICINE

Cystathionine as a marker for 1p/19q codeleted gliomas by in vivo magnetic resonance spectroscopy

(2019) Francesca Branzoli et al.   NEURO-ONCOLOGY

DeepCEST: 9.4 T Chemical exchange saturation transfer MRI contrast predicted from 3 T data - a proof of concept study

(2019) Moritz Zaiss et al.   MAGNETIC RESONANCE IN MEDICINE

Chemical exchange saturation transfer imaging of phosphocreatine in the muscle

(2019) Julius Juhyun Chung et al.   MAGNETIC RESONANCE IN MEDICINE

Intact metabolite spectrum mining by deep learning in proton magnetic resonance spectroscopy of the brain

(2019) Hyeong Hun Lee et al.   MAGNETIC RESONANCE IN MEDICINE

Magnetic resonance imaging is more sensitive than PET for detecting treatment-induced cell death-dependent changes in glycolysis

(2019) Richard L. Hesketh et al.   CANCER RESEARCH

Quantifying normal human brain metabolism using hyperpolarized [1–13C]pyruvate and magnetic resonance imaging

(2019) James T. Grist et al.   NEUROIMAGE

Quantifying amide proton exchange rate and concentration in chemical exchange saturation transfer imaging of the human brain

(2019) Hye-Young Heo et al.   NEUROIMAGE

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden

(2019) Zixuan Lin et al.   RADIOLOGY

Differential diagnosis of multiple system atrophy with predominant parkinsonism and Parkinson's disease using neural networks

(2019) Mitsunori Tsuda et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1

(2019) Kristin L. Granlund et al.   Cell Metabolism

Pilot Study Experiences With Hyperpolarized [1‐ 13 C]pyruvate MRI in Pancreatic Cancer Patients

(2019) Hans Stødkilde‐Jørgensen et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

CEST MR‐Fingerprinting: Practical considerations and insights for acquisition schedule design and improved reconstruction

(2019) Or Perlman et al.   MAGNETIC RESONANCE IN MEDICINE

Quantification of whole‐brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T 2 ‐based oxygenation calibrations

(2019) Wenbo Li et al.   MAGNETIC RESONANCE IN MEDICINE

Lactate topography of the human brain using hyperpolarized 13C-MRI

(2019) Casey Y. Lee et al.   NEUROIMAGE

Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study

(2019) Hsin-Yu Chen et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Super-Resolution 1H Magnetic Resonance Spectroscopic Imaging Utilizing Deep Learning

(2019) Zohaib Iqbal et al.   Frontiers in Oncology

Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain

(2019) Daniele Mammoli et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

DeepCEST 3T: Robust MRI parameter determination and uncertainty quantification with neural networks—application to CEST imaging of the human brain at 3T

(2019) Felix Glang et al.   MAGNETIC RESONANCE IN MEDICINE

Metabolic Imaging of the Human Brain with Hyperpolarized13C Pyruvate Demonstrates13C Lactate Production in Brain Tumor Patients

(2018) Vesselin Z. Miloushev et al.   CANCER RESEARCH

Magnetic resonance imaging of cancer metabolism with hyperpolarized 13 C-labeled cell metabolites

(2018) Richard L Hesketh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF)

(2018) Ouri Cohen et al.   MAGNETIC RESONANCE IN MEDICINE

Chemical exchange saturation transfer fingerprinting for exchange rate quantification

(2018) Zhengwei Zhou et al.   MAGNETIC RESONANCE IN MEDICINE

CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena

(2018) Linda Knutsson et al.   MAGNETIC RESONANCE IN MEDICINE

Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer

(2018) Hsin-Yu Chen et al.   MAGNETIC RESONANCE IN MEDICINE

A convolutional neural network to filter artifacts in spectroscopic MRI

(2018) Saumya S. Gurbani et al.   MAGNETIC RESONANCE IN MEDICINE

Reproducibility of 2D GluCEST in healthy human volunteers at 7 T

(2018) Ravi Prakash Reddy Nanga et al.   MAGNETIC RESONANCE IN MEDICINE

Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies

(2018) Ilwoo Park et al.   MAGNETIC RESONANCE IN MEDICINE

Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum

(2018) Peter C.M. van Zijl et al.   NEUROIMAGE

In vivo GluCEST MRI: Reproducibility, background contribution and source of glutamate changes in the MPTP model of Parkinson’s disease

(2018) Puneet Bagga et al.   Scientific Reports

Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line-shape fitting CEST method

(2018) Lin Chen et al.   MAGNETIC RESONANCE IN MEDICINE

Glutamate-sensitive imaging and evaluation of cognitive impairment in multiple sclerosis

(2018) Kristin P O’Grady et al.   Multiple Sclerosis Journal

Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients

(2018) Peder E. Z. Larson et al.   NMR IN BIOMEDICINE

Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo

(2018) Henk M. De Feyter et al.   Science Advances

Hyperpolarized 1-[ 13 C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer

(2017) Rahul Aggarwal et al.   EUROPEAN UROLOGY

Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice

(2017) Rachelle Crescenzi et al.   HIPPOCAMPUS

Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy

(2017) Ming Lu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Clinical applications of chemical exchange saturation transfer (CEST) MRI

(2017) Kyle M. Jones et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates

(2017) Andrea Capozzi et al.   Nature Communications

Transportable hyperpolarized metabolites

(2017) Xiao Ji et al.   Nature Communications

Hyperpolarized 13 C Metabolic MRI of the Human HeartNovelty and Significance

(2016) Charles H. Cunningham et al.   CIRCULATION RESEARCH

Reduced global brain metabolism but maintained vascular function in amnestic mild cognitive impairment

(2016) Binu P Thomas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Susceptibility-based time-resolved whole-organ and regional tissue oximetry

(2016) Felix W. Wehrli et al.   NMR IN BIOMEDICINE

Optimization of phase-contrast MRI for the quantification of whole-brain cerebral blood flow

(2015) Shin-Lei Peng et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Simultaneous Hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 Dogs with Cancer

(2015) H. Gutte et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging Metabolism with Hyperpolarized 13C-Labeled Cell Substrates

(2015) Kevin M. Brindle   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative theory for the longitudinal relaxation time of blood water

(2015) Wenbo Li et al.   MAGNETIC RESONANCE IN MEDICINE

Correction and optimization of a T2-based approach to map blood oxygenation in small cerebral veins

(2015) Lisa C. Krishnamurthy et al.   MAGNETIC RESONANCE IN MEDICINE

Regional quantification of cerebral venous oxygenation from MRI susceptibility during hypercapnia

(2015) Audrey P. Fan et al.   NEUROIMAGE

Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy

(2015) Kathryn Adamiak Davis et al.   Science Translational Medicine

A Comparison between Radiolabeled Fluorodeoxyglucose Uptake and Hyperpolarized 13C-Labeled Pyruvate Utilization as Methods for Detecting Tumor Response to Treatment

(2015) Timothy H. Witney et al.   NEOPLASIA

Hyperpolarized Magnetic Resonance as a Sensitive Detector of Metabolic Function

(2014) Arnaud Comment et al.   BIOCHEMISTRY

Quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) using quantitative susceptibility mapping (QSM)

(2014) Jingwei Zhang et al.   MAGNETIC RESONANCE IN MEDICINE

A technique for in vivo mapping of myocardial creatine kinase metabolism

(2014) Mohammad Haris et al.   NATURE MEDICINE

Chemistry and biochemistry of13C hyperpolarized magnetic resonance using dynamic nuclear polarization

(2013) Kayvan R. Keshari et al.   CHEMICAL SOCIETY REVIEWS

In vivo chemical exchange saturation transfer imaging of creatine (CrCEST) in skeletal muscle at 3T

(2013) Feliks Kogan et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Multimodal Assessment of In Vivo Metabolism with Hyperpolarized [1-13C]MR Spectroscopy and 18F-FDG PET Imaging in Hepatocellular Carcinoma Tumor-Bearing Rats

(2013) M. I. Menzel et al.   JOURNAL OF NUCLEAR MEDICINE

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

(2013) S. J. Nelson et al.   Science Translational Medicine

Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation

(2011) Hanzhang Lu et al.   MAGNETIC RESONANCE IN MEDICINE

Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI

(2009) Feng Xu et al.   MAGNETIC RESONANCE IN MEDICINE

Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading

(2008) M. J. Albers et al.   CANCER RESEARCH