Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

Amide Proton Transfer MRI Signal as a Surrogate Biomarker of Ischemic Stroke Recovery in Patients With Supportive Treatment

(2019) Lu Yu et al.   Frontiers in Neurology

pH-weighted amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) as a potential early biomarker for bevacizumab failure in recurrent glioblastoma

(2019) Jingwen Yao et al.   JOURNAL OF NEURO-ONCOLOGY

Causes, consequences, and therapy of tumors acidosis

(2019) Smitha R. Pillai et al.   CANCER AND METASTASIS REVIEWS

Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

(2019) Annasofia Anemone et al.   CANCER AND METASTASIS REVIEWS

T1ρ-based dynamic glucose-enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain

(2019) Kai Herz et al.   MAGNETIC RESONANCE IN MEDICINE

Quantification of hydroxyl exchange of D‐Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla

(2019) Moritz Zaiss et al.   NMR IN BIOMEDICINE

Sugar alcohol provides imaging contrast in cancer detection

(2019) Puneet Bagga et al.   Scientific Reports

Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms

(2019) Mohammed Albatany et al.   JOURNAL OF NEURO-ONCOLOGY

Challenges in glucoCEST MR body imaging at 3 Tesla

(2019) Mina Kim et al.   Quantitative Imaging in Medicine and Surgery

Parahydrogen-based Hyperpolarization for Biomedicine

(2018) Jan Hovener et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide

(2018) Mohammed Albatany et al.   International Journal of Clinical Oncology

Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging

(2018) Francesca Arena et al.   JOURNAL OF MAGNETIC RESONANCE

Preliminary Results that Assess Metformin Treatment in a Preclinical Model of Pancreatic Cancer Using Simultaneous [18F]FDG PET and acidoCEST MRI

(2018) Joshua M. Goldenberg et al.   MOLECULAR IMAGING AND BIOLOGY

Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multipool CEST MRI at 7.0 T

(2018) Daniel Paech et al.   NEURO-ONCOLOGY

Assessments of tumor metabolism with CEST MRI

(2018) Joshua M. Goldenberg et al.   NMR IN BIOMEDICINE

3-O-Methyl-d-glucose mutarotation and proton exchange rates assessed by 13C, 1H NMR and by chemical exchange saturation transfer and spin lock measurements

(2018) Michal Rivlin et al.   JOURNAL OF BIOMOLECULAR NMR

Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies

(2018) Austin R. Pantel et al.   JOURNAL OF NUCLEAR MEDICINE

CEST-MRI for glioma pH quantification in mouse model: Validation by immunohistochemistry

(2018) Giuseppe Ferrauto et al.   NMR IN BIOMEDICINE

Imaging in Vivo Extracellular pH with a Single Paramagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agent

(2018) Guanshu Liu et al.   Molecular Imaging

Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy

(2018) Shanshan Jiang et al.   CLINICAL CANCER RESEARCH

Direct radiofrequency saturation corrected amide proton transfer tumor MRI at 3T

(2018) Yin Wu et al.   MAGNETIC RESONANCE IN MEDICINE

Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma

(2017) Hao Yu et al.   EUROPEAN RADIOLOGY

Amide proton transfer imaging to discriminate between low- and high-grade gliomas: added value to apparent diffusion coefficient and relative cerebral blood volume

(2017) Yoon Seong Choi et al.   EUROPEAN RADIOLOGY

In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

(2017) Annasofia Anemone et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging

(2017) Dario Livio Longo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors

(2017) Akihiko Sakata et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Dichloroacetate induced intracellular acidification in glioblastoma: in vivo detection using AACID-CEST MRI at 9.4 Tesla

(2017) Mohammed Albatany et al.   JOURNAL OF NEURO-ONCOLOGY

Enantiomeric Recognition of d- and l-Lactate by CEST with the Aid of a Paramagnetic Shift Reagent

(2017) Lei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-caloric sweetener provides magnetic resonance imaging contrast for cancer detection

(2017) Puneet Bagga et al.   Journal of Translational Medicine

CEST MRI of 3-O-methyl-D-glucose on different breast cancer models

(2017) Michal Rivlin et al.   MAGNETIC RESONANCE IN MEDICINE

A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol

(2017) Yin Wu et al.   MAGNETIC RESONANCE IN MEDICINE

Direct saturation-corrected chemical exchange saturation transfer MRI of glioma: Simplified decoupling of amide proton transfer and nuclear overhauser effect contrasts

(2017) Iris Yuwen Zhou et al.   MAGNETIC RESONANCE IN MEDICINE

Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI

(2017) Shanshan Jiang et al.   MAGNETIC RESONANCE IN MEDICINE

Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI

(2017) Dario Livio Longo et al.   NMR IN BIOMEDICINE

T1ρ-weighted Dynamic Glucose-enhanced MR Imaging in the Human Brain

(2017) Daniel Paech et al.   RADIOLOGY

Therapeutic implications of tumor interstitial acidification

(2017) Iryna Kolosenko et al.   SEMINARS IN CANCER BIOLOGY

Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI

(2017) Patrick Schuenke et al.   Scientific Reports

Characterization of the Tumor Microenvironment and Tumor–Stroma Interaction by Non-invasive Preclinical Imaging

(2017) Nirilanto Ramamonjisoa et al.   Frontiers in Oncology

In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging

(2016) Dario L. Longo et al.   CANCER RESEARCH

MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent

(2016) Annasofia Anemone et al.   EUROPEAN RADIOLOGY

Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents

(2016) W. Shirangi Fernando et al.   INORGANIC CHEMISTRY

In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents

(2016) Dario Livio Longo et al.   INVESTIGATIVE RADIOLOGY

Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas

(2016) Bo Ma et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Topiramate induces acute intracellular acidification in glioblastoma

(2016) Kamini Marathe et al.   JOURNAL OF NEURO-ONCOLOGY

Adiabatically prepared spin-lock approach for T1ρ-based dynamic glucose enhanced MRI at ultrahigh fields

(2016) Patrick Schuenke et al.   MAGNETIC RESONANCE IN MEDICINE

Multislice CEST MRI improves the spatial assessment of tumor pH

(2016) Edward A. Randtke et al.   MAGNETIC RESONANCE IN MEDICINE

Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI

(2016) Kyle M. Jones et al.   MOLECULAR IMAGING AND BIOLOGY

Imaging the accumulation and suppression of tau pathology using multiparametric MRI

(2016) Holly E. Holmes et al.   NEUROBIOLOGY OF AGING

Probing lactate secretion in tumours with hyperpolarised NMR

(2016) Markus Durst et al.   NMR IN BIOMEDICINE

Assessing the transport rate of hyperpolarized pyruvate and lactate from the intra- to the extracellular space

(2016) Francesca Reineri et al.   NMR IN BIOMEDICINE

Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas

(2016) Daniel Coman et al.   NMR IN BIOMEDICINE

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate

(2016) Eva M. Serrao et al.   Frontiers in Oncology

Lactate Chemical Exchange Saturation Transfer (LATEST) Imaging in vivo: A Biomarker for LDH Activity

(2016) Catherine DeBrosse et al.   Scientific Reports

Magnetic Resonance Imaging of Glucose Uptake and Metabolism in Patients with Head and Neck Cancer

(2016) Jihong Wang et al.   Scientific Reports

Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors

(2016) Michal Rivlin et al.   Scientific Reports

Imaging Tumor Metabolism Using In Vivo Magnetic Resonance Spectroscopy

(2015) Yan Li et al.   CANCER JOURNAL

A comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that measure tumor extracellular pH

(2015) Brianna F. Moon et al.   Contrast Media & Molecular Imaging

Molecular MRI differentiation between primary central nervous system lymphomas and high-grade gliomas using endogenous protein-based amide proton transfer MR imaging at 3 Tesla

(2015) Shanshan Jiang et al.   EUROPEAN RADIOLOGY

Imaging Metabolism with Hyperpolarized 13C-Labeled Cell Substrates

(2015) Kevin M. Brindle   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic glucose enhanced (DGE) MRI for combined imaging of blood-brain barrier break down and increased blood volume in brain cancer

(2015) Xiang Xu et al.   MAGNETIC RESONANCE IN MEDICINE

Assessing Amide Proton Transfer (APT) MRI Contrast Origins in 9 L Gliosarcoma in the Rat Brain Using Proteomic Analysis

(2015) Kun Yan et al.   MOLECULAR IMAGING AND BIOLOGY

Evaluations of Tumor Acidosis Within In Vivo Tumor Models Using Parametric Maps Generated with AcidoCEST MRI

(2015) Liu Qi Chen et al.   MOLECULAR IMAGING AND BIOLOGY

pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI

(2015) Robert J. Harris et al.   NEURO-ONCOLOGY

Relaxation-compensated CEST-MRI of the human brain at 7 T: Unbiased insight into NOE and amide signal changes in human glioblastoma

(2015) Moritz Zaiss et al.   NEUROIMAGE

In vivo imaging of tau pathology using multi-parametric quantitative MRI

(2015) J.A. Wells et al.   NEUROIMAGE

Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine

(2015) Nevin McVicar et al.   NMR IN BIOMEDICINE

Quantitative chemical exchange saturation transfer (qCEST) MRI - omega plot analysis of RF-spillover-corrected inverse CEST ratio asymmetry for simultaneous determination of labile proton ratio and exchange rate

(2015) Renhua Wu et al.   NMR IN BIOMEDICINE

Quantitative description of radiofrequency (RF) power-based ratiometric chemical exchange saturation transfer (CEST) pH imaging

(2015) Renhua Wu et al.   NMR IN BIOMEDICINE

Correction ofB1-inhomogeneities for relaxation-compensated CEST imaging at 7 T

(2015) Johannes Windschuh et al.   NMR IN BIOMEDICINE

Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour

(2014) Dario Livio Longo et al.   ANALYST

Quantitative chemical exchange saturation transfer (qCEST) MRI - RF spillover effect-corrected omega plot for simultaneous determination of labile proton fraction ratio and exchange rate

(2014) Phillip Zhe Sun et al.   Contrast Media & Molecular Imaging

A General MRI-CEST Ratiometric Approach for pH Imaging: Demonstration of in Vivo pH Mapping with Iobitridol

(2014) Dario L. Longo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assessment of carbonic anhydrase IX expression and extracellular pH in B-cell lymphoma cell line models

(2014) Liu Qi Chen et al.   LEUKEMIA & LYMPHOMA

Functional molecular imaging of tumors by chemical exchange saturation transfer MRI of 3-O-Methyl-D-glucose

(2014) Michal Rivlin et al.   MAGNETIC RESONANCE IN MEDICINE

Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner

(2014) Anja Müller-Lutz et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

InverseZ-spectrum analysis for spillover-, MT-, andT1-corrected steady-state pulsed CEST-MRI - application to pH-weighted MRI of acute stroke

(2014) Moritz Zaiss et al.   NMR IN BIOMEDICINE

Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH

(2014) Phillip Zhe Sun et al.   PHYSICS IN MEDICINE AND BIOLOGY

Magnetic Resonance Imaging of the Tumor Microenvironment in Radiotherapy: Perfusion, Hypoxia, and Metabolism

(2014) Masayuki Matsuo et al.   SEMINARS IN RADIATION ONCOLOGY

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Imaging Brain Deoxyglucose Uptake and Metabolism by Glucocest MRI

(2013) Fatima A Nasrallah et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI

(2013) Liu Qi Chen et al.   MAGNETIC RESONANCE IN MEDICINE

In vivo maps of extracellular pH in murine melanoma by CEST-MRI

(2013) D Delli Castelli et al.   MAGNETIC RESONANCE IN MEDICINE

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

In vivo imaging of glucose uptake and metabolism in tumors

(2013) Simon Walker-Samuel et al.   NATURE MEDICINE

Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades

(2013) O. Togao et al.   NEURO-ONCOLOGY

Nuts and bolts of chemical exchange saturation transfer MRI

(2013) Guanshu Liu et al.   NMR IN BIOMEDICINE

Molecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI

(2013) Michal Rivlin et al.   Scientific Reports

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

CEST: From basic principles to applications, challenges and opportunities

(2012) Elena Vinogradov et al.   JOURNAL OF MAGNETIC RESONANCE

Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent

(2012) Dario Livio Longo et al.   MAGNETIC RESONANCE IN MEDICINE

Amide proton transfer imaging of the breast at 3 T: Establishing reproducibility and possible feasibility assessing chemotherapy response

(2012) Adrienne N. Dula et al.   MAGNETIC RESONANCE IN MEDICINE

NaturalD-glucose as a biodegradable MRI contrast agent for detecting cancer

(2012) Kannie W. Y. Chan et al.   MAGNETIC RESONANCE IN MEDICINE

Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment

(2011) Yanique I. Rattigan et al.   EXPERIMENTAL CELL RESEARCH

Amide proton transfer MR imaging of prostate cancer: A preliminary study

(2011) Guang Jia et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Chemical exchange saturation transfer (CEST): What is in a name and what isn't?

(2011) Peter C. M. van Zijl et al.   MAGNETIC RESONANCE IN MEDICINE

Measuring in vivo tumor pHe with CEST-FISP MRI

(2011) Vipul R. Sheth et al.   MAGNETIC RESONANCE IN MEDICINE

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolic Tumor Imaging Using Magnetic Resonance Spectroscopy

(2011) Kristine Glunde et al.   SEMINARS IN ONCOLOGY

Metabolic Positron Emission Tomography Imaging in Cancer Detection and Therapy Response

(2011) Aizhi Zhu et al.   SEMINARS IN ONCOLOGY

CEST and PARACEST MR contrast agents

(2010) Ileana Hancu et al.   ACTA RADIOLOGICA

A concentration-independent method to measure exchange rates in PARACEST agents

(2010) W. Thomas Dixon et al.   MAGNETIC RESONANCE IN MEDICINE

Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T

(2010) Dario Livio Longo et al.   MAGNETIC RESONANCE IN MEDICINE

Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides

(2010) Jinyuan Zhou et al.   NATURE MEDICINE

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor metabolism: cancer cells give and take lactate

(2008) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts

(2007) Amandeep Salhotra et al.   NMR IN BIOMEDICINE