Article
Cell Biology
Hope E. Burks, Jenny L. Pokorny, Jennifer L. Koetsier, Quinn R. Roth-Carter, Christopher R. Arnette, Pedram Gerami, John T. Seykora, Jodi L. Johnson, Ziyou Ren, Kathleen J. Green
Summary: Melanoma cells hijack keratinocyte signaling to downregulate Dsg1 expression, leading to increased migration and epidermal spread. Paracrine signaling via CXCL1/CXCR2 and regulation of Slug and Grhl1 are involved in this intercellular communication.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Dermatology
Weixue Jia, Yuanyuan Zhang, Xue Wang, Lingling Luo, Heng Sun, Yiqun Jiang, Jianbo Wang, Qiuxia Mao, Youming Guo, Lingzhuo Kong, Ran Mo, Chengrang Li
Summary: This study reveals that the downregulation of KRT5 in keratinocytes affects melanogenesis in melanocytes through the Notch signaling pathway. The findings provide insights into the molecular mechanism of KRT5-Notch signaling pathway in the regulation of melanocytes and shed light on the mechanism of DDD pigment abnormality caused by KRT5 mutation. These findings identify potential therapeutic targets of the Notch signaling pathway for the treatment of skin pigment disorders.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Pathology
Furkan Akif Ince, Artur Shariev, Katie Dixon
Summary: PTEN is a crucial tumor suppressor protein and its mutations are frequently observed in various cancers. The interactions between PTEN and other molecules in melanoma can have either positive or negative effects on melanoma pathogenesis.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Oncology
Viviana P. Orellana, Andres Tittarelli, Mauricio A. Retamal
Summary: Melanoma is an aggressive skin cancer that is refractory to chemotherapy in advanced stages, making it important to understand the molecular basis of its aggressiveness. Connexins (Cxs) play important roles in cancer progression and metastasis, with Cx26 and Cx43 being key players in melanoma progression, while Cx46, typically expressed in the eye lens, has been associated with cancer stem cell properties and extracellular vesicle release in breast and brain cancers in recent years. The potential role of Cx46 as a new biomarker and therapeutic target in melanoma is analyzed in this review.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Oncology
Aneta Sciezynska, Anna Sobiepanek, Patrycja D. Kowalska, Marta Soszynska, Krzysztof Luszczynski, Tomasz M. Grzywa, Natalia Krzesniak, Agata Gozdz, Pawel K. Wlodarski, Ryszard Galus, Tomasz Kobiela, Jacek Malejczyk
Summary: This paper describes a novel, non-enzymatic and effective method of isolating skin melanocytes and metastatic melanoma cells from skin or lymph node explants, which retain their natural phenotypical features and are not contaminated by keratinocytes and fibroblasts. The isolated cells display specific phenotypical and functional features such as tyrosinase and Melan-A expression, making them valuable for medical and cosmetic studies, including antitumor therapy research.
Article
Cell Biology
Shuang-Hai Hu, Shan Jiang, Fang Miao, Tie-Chi Lei
Summary: The release of sPmel17 protein from melanocytes (MCs) after exposure to UVB weakens cell-cell adhesions in keratinocytes (KCs), facilitating the migration of MCs to areas devoid of MCs. The upregulation of FHL2 in KCs requires stimulation by sPmel17 released from UVB-exposed MCs, and the activation of the sPmel17-FHL2-E-cadherin axis offers a potential therapeutic target to expedite repigmentation in patients with vitiligo.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemical Research Methods
Margaux Bouzin, Mario Marini, Giuseppe Chirico, Francesca Granucci, Francesca Mingozzi, Roberto Colombo, Laura D'Alfonso, Laura Sironi, Maddalena Collini
Summary: This study proposes a non-destructive photo-thermal imaging method that can characterize the distribution and concentration of melanin pigments in excised melanoma biopsies. It provides a label-free super-resolution far-infrared thermal imaging of tissue sections, allowing for the quantitative analysis of melanin content. The proposed method could complement traditional histopathology in the characterization of pigmented lesions ex-vivo.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Biochemistry & Molecular Biology
Emmanouil Karampinis, Athina-Maria Aloizou, Efterpi Zafiriou, Alexandra Bargiota, Zoi Skaperda, Demetrios Kouretas, Angeliki-Viktoria Roussaki-Schulze
Summary: UV radiation has both harmful and beneficial effects on skin health. It can cause oxidative stress, leading to skin cancer and photoaging. However, it is also necessary for the production of vitamin D, which has important antioxidant and anticancer properties. This study found that skin cancer patients have lower levels of vitamin D and increased oxidative stress.
Article
Dermatology
Hafeez Rahman, Dileep Kumar, Tong Liu, Nwanneka Okwundu, David Lum, Scott R. Florell, Christin E. Burd, Kenneth M. Boucher, Matthew W. VanBrocklin, Douglas Grossman
Summary: Aspirin can reduce UVB-induced DNA damage and skin cancer, decrease inflammation and DNA damage lesions, and delay the onset of non-melanoma and squamous cell carcinoma while translating into greater chemopreventive efficacy than melanoma in mouse models.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Surgery
Richard C. Maduka, Karen Tai, Radha Gonsai, Nick DeWalt, Ashwin Chetty, Alexandria Brackett, Kelly Olino, Eric B. Schneider, Vanita Ahuja
Summary: This article critically evaluates the relationship between chronic occupational exposure to sunlight and the risk of developing cutaneous melanoma. A total of 14 articles were analyzed, and results showed no difference in the likelihood of developing melanoma between outdoor and indoor occupation groups. Further research is needed to identify other occupational or lifestyle-related risk factors and improve early detection of melanoma.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Biology
Otilia Gag, Stefania Dinu, Horatiu Manea, Iasmina Marcovici, Iulia Pinzaru, Ramona Popovici, Zorin Crainiceanu, Zsolt Gyori, Gheorghe Iovanescu, Sorin Chiriac
Summary: This study evaluated the phototoxic effects of UVA and UVB radiation on healthy and pathologic skin cells. The results showed that UVA had no cytotoxicity on the tested cells, while UVB significantly reduced cell viability and induced apoptosis. The combination of UVA and UVB resulted in the highest cytotoxicity. The findings provide insights into the behavior of normal and cancer skin cells under UVR treatments.
Article
Pathology
Emi Dika, Nico Curti, Enrico Giampieri, Giulia Veronesi, Cosimo Misciali, Costantino Ricci, Gastone Castellani, Annalisa Patrizi, Emanuela Marcelli
Summary: This study explores the potential of using a machine-based algorithm to assist in the histopathologic diagnosis of cutaneous malignant melanoma, achieving a high accuracy rate and providing a possible solution for automated diagnosis in the future.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell Biology
Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Magdalena Kot, Katarzyna Pietraszek-Gremplewicz, Dominika Wilk, Marcin Zietek, Rafal Matkowski, Dorota Nowak
Summary: This study provides a more in-depth understanding of the role of keratinocytes in the melanoma microenvironment, highlighting their unique secretome and mediators of invasive abilities, which could be utilized by cancer cells to support their invasion of surrounding tissues.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Dermatology
Muhammad Mubashshir, Nabeel Ahmad, Helen Nilsson Skoeld, Mohd Ovais
Summary: Melatonin affects mammalian coat color, hair follicle pigmentation, and retinal cell responses. Its direct effects on melanocytes and human skin pigmentation are still uncertain. Melatonin acts as a free radical scavenger and inhibits cancer cell growth. Melanocytes and melanoma cells can be used as in vitro test models for pharmacological applications.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dermatology
Neetu Bhari, Robert A. Schwaertz, Zoe Apalla, Gabriel Salerni, Bengu Nisa Akay, Anant Patil, Stephan Grabbe, Mohamad Goldust
Summary: Estrogen receptors alpha and beta play a key role in melanoma, with ER beta being the principal receptor. While the exact role of estrogen in the pathogenesis and progression of melanoma remains uncertain, evidence suggests that estrogen stimulation influences its growth and metastasis. Further research into specific genetic mutations and targeted therapies is needed for effective treatment, especially in advanced cases of melanoma.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Editorial Material
Dermatology
Kathleen J. Green, Carien M. Niessen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Letter
Dermatology
Anna Balato, Martina Mattii, Giuseppina Caiazzo, Annunziata Raimondo, Cataldo Patruno, Nicola Balato, Fabio Ayala, Serena Lembo
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Letter
Dermatology
Jodi L. Johnson, Paul Hoover, Borko D. Jovanovic, Kathleen J. Green, John J. Friedewald, June K. Robinson
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Article
Biology
Nicole Ann Najor, Gillian Nicole Fitz, Jennifer Leigh Koetsier, Lisa Marie Godsel, Lauren Veronica Albrecht, Robert Harmon, Kathleen Janee Green
Article
Cell Biology
Chen Yuan Kam, Adi D. Dubash, Elisa Magistrati, Simona Polo, Karla J. F. Satchell, Farah Sheikh, Paul D. Lampe, Kathleen J. Green
JOURNAL OF CELL BIOLOGY
(2018)
Editorial Material
Dermatology
Mark C. Udey, Jodi L. Johnson
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Review
Infectious Diseases
Christopher G. Bunick, Jonette Keri, S. Ken Tanaka, Nika Furey, Giovanni Damiani, Jodi L. Johnson, Ayman Grada
Summary: Sarecycline, a narrow-spectrum third-generation tetracycline-class antibiotic approved by the FDA for treating moderate-to-severe acne, exhibits activity against Gram-positive bacteria, particularly Staphylococcus aureus, with reduced efficacy against Gram-negative bacteria like Escherichia coli. Its unique C7 moiety interacts with bacterial ribosomes to block translation and prevent resistance, showing promising results in in vivo studies of infection and inflammation.
Editorial Material
Cell Biology
Joshua A. Broussard, Kathleen J. Green
Summary: The integration of cytoskeletal/adhesive networks is crucial for epithelial mechanobiology. This study demonstrates that plectin, a cytolinker protein, is essential for the construction of a cortical cytoskeletal architecture required for epithelial tensional homeostasis.
JOURNAL OF CELL BIOLOGY
(2022)
Editorial Material
Dermatology
Jodi L. Johnson, Sara J. Brown, Lu Q. Le, Mark C. Udey
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Editorial Material
Dermatology
Jodi L. Johnson, Erwin Tschachler
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Cell Biology
Hope E. Burks, Jenny L. Pokorny, Jennifer L. Koetsier, Quinn R. Roth-Carter, Christopher R. Arnette, Pedram Gerami, John T. Seykora, Jodi L. Johnson, Ziyou Ren, Kathleen J. Green
Summary: Melanoma cells hijack keratinocyte signaling to downregulate Dsg1 expression, leading to increased migration and epidermal spread. Paracrine signaling via CXCL1/CXCR2 and regulation of Slug and Grhl1 are involved in this intercellular communication.
JOURNAL OF CELL BIOLOGY
(2023)