Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Brg1 Inhibition Prevents Liver Fibrosis and Cholangiocarcinoma by Attenuating Progenitor Expansion

(2021) Yongjie Zhou et al.   HEPATOLOGY

A CD44/Brg1 nuclear complex confers mesenchymal progenitor cells with enhanced fibrogenicity in idiopathic pulmonary fibrosis

(2021) Libang Yang et al.   JCI Insight

The emerging role of cellular senescence in renal diseases

(2020) Bingru Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways

(2020) Xiuhua Wu et al.   Oxidative Medicine and Cellular Longevity

Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

(2020) Shahrokh Lorzadeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy

(2019) Shuting Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The senescence-associated secretory phenotype and its regulation

(2019) Stéphane Lopes-Paciencia et al.   CYTOKINE

Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway

(2019) Fenfen Peng et al.   LABORATORY INVESTIGATION

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

(2019) Jinhua Miao et al.   AGING CELL

TGF-β mediates aortic smooth muscle cell senescence in Marfan syndrome

(2019) Wei You et al.   Aging-US

Endothelial-specific deletion of Brahma-related gene 1 (BRG1) assuages unilateral ureteral obstruction induced renal injury in mice

(2019) Li Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EtNBSe-PDT inhibited proliferation and induced autophagy of HNE-1 cells via downregulating the Wnt/β-catenin signaling pathway

(2019) An Liu et al.   Photodiagnosis and Photodynamic Therapy

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

(2019) Seo Rin Kim et al.   Translational Research

BRG1 regulates endothelial-derived IL-33 to promote ischemia-reperfusion induced renal injury and fibrosis in mice

(2019) Li Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

(2019) Rohan Samarakoon et al.   Biomolecules

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

(2019) Kana Tominaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Micheliolide ameliorates diabetic kidney disease by inhibiting Mtdh-mediated renal inflammation in type 2 diabetic db/db mice

(2019) Wenting Liu et al.   PHARMACOLOGICAL RESEARCH

Acute Kidney Injury as a Condition of Renal Senescence

(2018) Lucia Andrade et al.   CELL TRANSPLANTATION

Brg1 promotes liver fibrosis via activation of hepatic stellate cells

(2018) Haijie Li et al.   EXPERIMENTAL CELL RESEARCH

Brahma related gene 1 (Brg1) contributes to liver regeneration by epigenetically activating the Wnt/β-catenin pathway in mice

(2018) Nan Li et al.   FASEB JOURNAL

Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

(2018) Congwei Luo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal fibrosis: Primacy of the proximal tubule

(2018) Leslie S. Gewin   MATRIX BIOLOGY

Accelerated Glomerular Cell Senescence in Experimental Lupus Nephritis

(2018) Chen Yang et al.   MEDICAL SCIENCE MONITOR

New insights into the role and mechanism of Wnt/β-catenin signalling in kidney fibrosis

(2018) Yangyang Zuo et al.   NEPHROLOGY

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Structural and Functional Changes in Human Kidneys with Healthy Aging

(2017) Musab S. Hommos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

(2017) Adeera Levin et al.   LANCET

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway

(2017) Guihua Wang et al.   Cell Death & Disease

The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer

(2017) Qiong Wu et al.   Epigenomics

Cellular senescence in the aging and diseased kidney

(2017) F. A. Valentijn et al.   Journal of Cell Communication and Signaling

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

(2015) Bhavatarini Vangamudi et al.   CANCER RESEARCH

Sustained Activation of Wnt/ -Catenin Signaling Drives AKI to CKD Progression

(2015) L. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Brg-1 targeting of novel miR550a-5p/RNF43/Wnt signaling axis regulates colorectal cancer metastasis

(2015) G Wang et al.   ONCOGENE

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

(2015) O. Fedorov et al.   Science Advances

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

(2014) Yao-Huei Huang et al.   Autophagy

Autophagy Regulates TGF-  Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction

(2014) Y. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Maladaptive Proximal Tubule Repair: Cell Cycle Arrest

(2014) Joseph V. Bonventre   NEPHRON CLINICAL PRACTICE

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Wnt/β-catenin signaling and kidney fibrosis

(2014) Roderick J. Tan et al.   Kidney International Supplements

The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults

(2013) Andrew D. Rule   ANNALS OF INTERNAL MEDICINE

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

BRG1 Is Required for Formation of Senescence-Associated Heterochromatin Foci Induced by Oncogenic RAS or BRCA1 Loss

(2013) Zhigang Tu et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased Cellular Senescence and Vascular Rarefaction Exacerbate the Progression of Kidney Fibrosis in Aged Mice Following Transient Ischemic Injury

(2013) Meghan E. Clements et al.   PLoS One

Suppression of replicative senescence by rapamycin in rodent embryonic cells

(2012) Tatyana V. Pospelova et al.   CELL CYCLE

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

Cellular Senescence Limits Regenerative Capacity and Allograft Survival

(2012) H. Braun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy

(2012) Grazyna Mosieniak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagic activity dictates the cellular response to oncogenic RAS

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

(2011) Aaron Ciechanover   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels

(2011) C. T. Griffin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy

(2011) Jun Liu et al.   Translational Research

Chronic Kidney Disease and End-Stage Renal Disease in the Elderly Population: Current Prevalence, Future Projections, and Clinical Significance

(2010) Lesley A. Stevens et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

BRG1 Increases Transcription of Proinflammatory Genes in Renal Ischemia

(2009) M. Naito et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells

(2009) S R Naidu et al.   ONCOGENE

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Hypertension Induces Somatic Cellular Senescence in Rats and Humans by Induction of Cell Cycle Inhibitor p16 INK4a

(2008) Jens H. Westhoff et al.   HYPERTENSION

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY