Intermittent fasting in paediatric critical illness: The properties and potential beneficial effects of an overnight fast in the PICU

Nutritional support for children during critical illness: European Society of Pediatric and Neonatal Intensive Care (ESPNIC) metabolism, endocrine and nutrition section position statement and clinical recommendations

(2020) Lyvonne N. Tume et al.   INTENSIVE CARE MEDICINE

Effect of Intermittent or Continuous Feed on Muscle Wasting in Critical Illness

(2020) Angela S. McNelly et al.   CHEST

Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients

(2020) Franny Jongbloed et al.   Aging-US

Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest

(2020) Javier T. Gonzalez et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

(2020) Stefanie de Groot et al.   Nature Communications

Glycemic Variability: An Independent Predictor of Mortality and the Impact of Age in Pediatric Intensive Care Unit

(2020) Yuhui Du et al.   Frontiers in Pediatrics

Long-term developmental effect of withholding parenteral nutrition in paediatric intensive care units: a 4-year follow-up of the PEPaNIC randomised controlled trial

(2020) An Jacobs et al.   Lancet Child & Adolescent Health

Intermittent fasting as a nutrition approach against obesity and metabolic disease

(2020) Shengjie Zhu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Intermittent versus continuous enteral nutrition on feeding intolerance in critically ill adults: A meta-analysis of randomized controlled trials

(2020) Yuanyuan Ma et al.   INTERNATIONAL JOURNAL OF NURSING STUDIES

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU

(2020) Ines Verlinden et al.   Clinical Epigenetics

The ketogenic diet for super-refractory status epilepticus patients in intensive care units

(2019) Eu Gene Park et al.   BRAIN & DEVELOPMENT

Early Motor-Behavioral Outcome of Ischemic Stroke with Ketogenic Diet Preconditioning: Interventional Animal Study

(2019) Sheida Shaafi et al.   Journal of Stroke & Cerebrovascular Diseases

Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling

(2019) K. Okoshi et al.   BMC Cardiovascular Disorders

Definitions, predictors and outcomes of feeding intolerance in critically ill children: A systematic review

(2019) R.D. Eveleens et al.   CLINICAL NUTRITION

Intermittent or continuous feeding

(2019) Lisa Van Dyck et al.   Current Opinion in Critical Care

Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury

(2019) Pedro Rojas-Morales et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy flux in critical illness, a translational approach

(2019) Nicolas Tardif et al.   Scientific Reports

Delirium in a Tertiary PICU

(2019) Leslie A. Dervan et al.   Pediatric Critical Care Medicine

Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury

(2019) Pedro Rojas-Morales et al.   Biomolecules

Continuous feeding versus intermittent bolus feeding for premature infants with low birth weight: a meta-analysis of randomized controlled trials

(2019) Yan Wang et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

The behavioural and pathophysiological effects of the ketogenic diet on mild traumatic brain injury in adolescent rats

(2019) Sabrina Salberg et al.   BEHAVIOURAL BRAIN RESEARCH

The effects of fasting on drug metabolism

(2019) Laureen A. Lammers et al.   Expert Opinion on Drug Metabolism & Toxicology

Effects of Intermittent Fasting on Health, Aging, and Disease

(2019) Rafael de Cabo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

(2018) Elizabeth F. Sutton et al.   Cell Metabolism

ESPGHAN/ESPEN/ESPR guidelines on pediatric parenteral nutrition: Energy

(2018) K. Joosten et al.   CLINICAL NUTRITION

Intermittent metabolic switching, neuroplasticity and brain health

(2018) Mark P. Mattson et al.   NATURE REVIEWS NEUROSCIENCE

Methods of Enteral Nutrition Administration in Critically Ill Patients: Continuous, Cyclic, Intermittent, and Bolus Feeding

(2018) Satomi Ichimaru   NUTRITION IN CLINICAL PRACTICE

Metabolic phenotype of skeletal muscle in early critical illness

(2018) Zudin A Puthucheary et al.   THORAX

Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress

(2018) Min Guo et al.   Frontiers in Molecular Neuroscience

Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis

(2018) Kathryn C. Fitzgerald et al.   Multiple Sclerosis and Related Disorders

A safe and efficacious preventive strategy in the high-risk surgical neonate: cycled total parenteral nutrition

(2018) Joseph A. Sujka et al.   PEDIATRIC SURGERY INTERNATIONAL

Circadian Rhythm Disruption and Sepsis in Severe Trauma Patients

(2018) Benjamin Coiffard et al.   SHOCK

Long-term developmental effects of withholding parenteral nutrition for 1 week in the paediatric intensive care unit: a 2-year follow-up of the PEPaNIC international, randomised, controlled trial

(2018) Sören Verstraete et al.   Lancet Respiratory Medicine

Bolus vs Continuous Nasogastric Feeds in Mechanically Ventilated Pediatric Patients: A Pilot Study

(2018) Ann-Marie Brown et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting

(2017) Stephen D. Anton et al.   Obesity

Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient

(2017) Nilesh M. Mehta et al.   Pediatric Critical Care Medicine

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

(2017) Min Wei et al.   Science Translational Medicine

A signature of renal stress resistance induced by short-term dietary restriction, fasting and protein restriction

(2017) F. Jongbloed et al.   Scientific Reports

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

(2017) Devin Wahl et al.   Clinical Interventions in Aging

Effect of early supplemental parenteral nutrition in the paediatric ICU: a preplanned observational study of post-randomisation treatments in the PEPaNIC trial

(2017) Ilse Vanhorebeek et al.   Lancet Respiratory Medicine

The Role of Autophagy in Critical Illness-induced Liver Damage

(2017) Steven E. Thiessen et al.   Scientific Reports

Effects of Bolus and Continuous Nasogastric Feeding on Gastric Emptying, Small Bowel Water Content, Superior Mesenteric Artery Blood Flow, and Plasma Hormone Concentrations in Healthy Adults

(2016) Abeed H. Chowdhury et al.   ANNALS OF SURGERY

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

(2016) Krisztina Marosi et al.   JOURNAL OF NEUROCHEMISTRY

Impact of Continuous vs Bolus Feeding on Splanchnic Perfusion in Very Low Birth Weight Infants: A Randomized Trial

(2016) Valentina Bozzetti et al.   JOURNAL OF PEDIATRICS

Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

(2016) Tatiana Moro et al.   Journal of Translational Medicine

Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury

(2016) Christine R. Mauro et al.   JOURNAL OF VASCULAR SURGERY

Early versus Late Parenteral Nutrition in Critically Ill Children

(2016) Tom Fivez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of two different feeding methods on preventing ventilator associated pneumonia in the paediatric intensive care unit (PICU): A randomised controlled study

(2016) Duygu Sönmez Düzkaya et al.   Australian Critical Care

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

(2016) In Young Choi et al.   Cell Reports

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness

(2016) Chloë Goossens et al.   Journal of Cachexia Sarcopenia and Muscle

Adequate enteral protein intake is inversely associated with 60-d mortality in critically ill children: a multicenter, prospective, cohort study1

(2015) Nilesh M Mehta et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

The ketogenic diet in pharmacoresistant childhood epilepsy

(2015) Steven Parrish Winesett et al.   Expert Review of Neurotherapeutics

Impact of withholding early parenteral nutrition completing enteral nutrition in pediatric critically ill patients (PEPaNIC trial): study protocol for a randomized controlled trial

(2015) Tom Fivez et al.   Trials

The ketogenic diet in pharmacoresistant childhood epilepsy

(2015) Steven Parrish Winesett et al.   Expert Review of Neurotherapeutics

Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis

(2014) A. REINTAM BLASER et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Acute Outcomes and 1-Year Mortality of Intensive Care Unit–acquired Weakness. A Cohort Study and Propensity-matched Analysis

(2014) Greet Hermans et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The effect of a multicomponent multidisciplinary bundle of interventions on sleep and delirium in medical and surgical intensive care patients

(2014) J. Patel et al.   ANAESTHESIA

Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges

(2014) Amandine Chaix et al.   Cell Metabolism

Weight-for-age distribution and case-mix adjusted outcomes of 14,307 paediatric intensive care admissions

(2014) Nicholas J. Prince et al.   INTENSIVE CARE MEDICINE

Intermittent Fasting Attenuates Increases in Neurogenesis after Ischemia and Reperfusion and Improves Recovery

(2014) Silvia Manzanero et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment

(2014) Andrea R Vasconcelos et al.   Journal of Neuroinflammation

Early Enteral Nutrition Is Associated With Lower Mortality in Critically Ill Children

(2014) Theresa A. Mikhailov et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women

(2013) Michelle Harvie et al.   BRITISH JOURNAL OF NUTRITION

Physical Complications in Acute Lung Injury Survivors

(2013) Eddy Fan et al.   CRITICAL CARE MEDICINE

Delirium: A disturbance of circadian integrity?

(2013) James M. Fitzgerald et al.   MEDICAL HYPOTHESES

Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial

(2013) Greet Hermans et al.   Lancet Respiratory Medicine

Autophagy and the Immune System

(2012) Petric Kuballa et al.   Annual Review of Immunology

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Nutritional practices and their relationship to clinical outcomes in critically ill children—An international multicenter cohort study*

(2012) Nilesh M. Mehta et al.   CRITICAL CARE MEDICINE

Insufficient Autophagy Contributes to Mitochondrial Dysfunction, Organ Failure, and Adverse Outcome in an Animal Model of Critical Illness*

(2012) Jan Gunst et al.   CRITICAL CARE MEDICINE

Early Parenteral Nutrition Evokes a Phenotype of Autophagy Deficiency in Liver and Skeletal Muscle of Critically Ill Rabbits

(2012) Sarah Derde et al.   ENDOCRINOLOGY

Timed high-fat diet resets circadian metabolism and prevents obesity

(2012) Hadas Sherman et al.   FASEB JOURNAL

Effect of Tight Glucose Control with Insulin on the Thyroid Axis of Critically Ill Children and Its Relation with Outcome

(2012) Marijke Gielen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Continuous Parenteral and Enteral Nutrition Induces Metabolic Dysfunction in Neonatal Pigs

(2012) Barbara Stoll et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations

(2012) Cynthia M Kroeger et al.   Nutrition & Metabolism

Abnormalities in glucose homeostasis in critically Ill children*

(2012) Tsultem D. Bhutia et al.   Pediatric Critical Care Medicine

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

(2012) C. Lee et al.   Science Translational Medicine

Nutrition Support in Critically Ill Children: Underdelivery of Energy and Protein Compared with Current Recommendations

(2012) Ursula G. Kyle et al.   Journal of the Academy of Nutrition and Dietetics

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

The obesity paradox in surgical intensive care unit patients

(2011) Robert Hutagalung et al.   INTENSIVE CARE MEDICINE

Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients

(2011) Ilse Vanhorebeek et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Intermittent Fasting Improves Functional Recovery after Rat Thoracic Contusion Spinal Cord Injury

(2011) Mi-ae Jeong et al.   JOURNAL OF NEUROTRAUMA

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Early versus Late Parenteral Nutrition in Critically Ill Adults

(2011) Michael P. Casaer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Melatonin status in pediatric intensive care patients with sepsis*

(2011) Soyhan Bagci et al.   Pediatric Critical Care Medicine

Role of clock genes in gastrointestinal motility

(2010) Willemijntje A. Hoogerwerf   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Skeletal muscle dysfunction in critical care: Wasting, weakness, and rehabilitation strategies

(2010) Zudin Puthucheary et al.   CRITICAL CARE MEDICINE

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

(2010) M N Harvie et al.   INTERNATIONAL JOURNAL OF OBESITY

Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration

(2010) Mariëlle Verweij et al.   LIVER TRANSPLANTATION

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Metabolic Effects of Cyclic Parenteral Nutrition Infusion in Adults and Children

(2010) Stephen Marc Stout et al.   NUTRITION IN CLINICAL PRACTICE

Age and energy intake interact to modify cell stress pathways and stroke outcome

(2009) Thiruma V. Arumugam et al.   ANNALS OF NEUROLOGY

The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats

(2009) Zhi-Gang Hu et al.   BRAIN INJURY

Glucose control in the intensive care unit

(2009) Brenda G. Fahy et al.   CRITICAL CARE MEDICINE

Challenges to Optimal Enteral Nutrition in a Multidisciplinary Pediatric Intensive Care Unit

(2009) Nilesh M. Mehta et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Alterations in glucose homeostasis in the pediatric intensive care unit: Hyperglycemia and glucose variability are associated with increased mortality and morbidity*

(2009) Eliotte Hirshberg et al.   Pediatric Critical Care Medicine

Caloric restriction improves memory in elderly humans

(2009) A. V. Witte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Acquired Weakness, Handgrip Strength, and Mortality in Critically Ill Patients

(2008) Naeem A. Ali et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Dietary restriction started after spinal cord injury improves functional recovery

(2008) Ward T. Plunet et al.   EXPERIMENTAL NEUROLOGY

Food restriction induces long-lasting recovery of spatial memory deficits following global ischemia in delayed matching and non-matching-to-sample radial arm maze tasks

(2008) M.-C. Roberge et al.   NEUROSCIENCE

Glucose control, organ failure, and mortality in pediatric intensive care*

(2008) Michael Yung et al.   Pediatric Critical Care Medicine