Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies

Tau Aggregates: Toxic, Inert, or Protective Species?

(2017) Alexis Bretteville et al.   JOURNAL OF ALZHEIMERS DISEASE

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

(2015) Charles R. Harrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

(2015) Ismael Santa-Maria et al.   JOURNAL OF CLINICAL INVESTIGATION

Tau Immunotherapy Modulates Both Pathological Tau and Upstream Amyloid Pathology in an Alzheimer's Disease Mouse Model

(2015) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Determinants of amyloid fibril degradation by the PDZ protease HTRA1

(2015) Simon Poepsel et al.   Nature Chemical Biology

Understanding Biomarkers of Neurodegeneration: Novel approaches to detecting tau pathology

(2015) Casey N Cook et al.   NATURE MEDICINE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Drugging RNAi

(2015) D. Haussecker et al.   SCIENCE

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Connecting the dots between tau dysfunction and neurodegeneration

(2015) Bess Frost et al.   TRENDS IN CELL BIOLOGY

In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease

(2014) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies

(2014) Kevin Lou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clearing the way for tau immunotherapy in Alzheimer's disease

(2014) Abigail Herrmann et al.   JOURNAL OF NEUROCHEMISTRY

Motor and cognitive deficits in aged tau knockout mice in two background strains

(2014) Peng Lei et al.   Molecular Neurodegeneration

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

(2014) Mariet Allen et al.   Alzheimers Research & Therapy

The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease

(2013) Paula Merino-Serrais et al.   BRAIN

MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells

(2013) Elena Tortosa et al.   EMBO JOURNAL

Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing

(2013) María Elena Avale et al.   HUMAN MOLECULAR GENETICS

Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models

(2013) Xuemei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The microtubule-associated tau protein has intrinsic acetyltransferase activity

(2013) Todd J Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role ofMAPTsequence variation in mechanisms of disease susceptibility: Figure 1

(2012) Tara M. Caffrey et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

The MAPT locus—a genetic paradigm in disease susceptibility

(2012) Richard Wade-Martins   Nature Reviews Neurology

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles

(2011) Diana Simón et al.   FEBS LETTERS

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

(2011) Jonathan Gilley et al.   NEUROBIOLOGY OF AGING

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Tau Pathology and Future Therapeutics

(2010) I. Gozes   Current Alzheimer Research

Plus-End-Tracking Proteins and Their Interactions at Microtubule Ends

(2010) Niels Galjart   CURRENT BIOLOGY

Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression

(2010) Elena Gómez de Barreda et al.   FEBS LETTERS

Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases

(2010) H. Sudo et al.   HUMAN MOLECULAR GENETICS

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model

(2010) A. Boutajangout et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Caspases first

(2010) Jesús Avila   Nature Reviews Neurology

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

An association study of common variation at theMAPTlocus with late-onset Alzheimer's disease

(2009) Richard Abraham et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Development of Tau Aggregation Inhibitors for Alzheimer's Disease

(2009) Bruno Bulic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chaperone-Like Antibodies in Neurodegenerative Tauopathies: Implication for Immunotherapy

(2009) Eva Kontsekova et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mammalian end binding proteins control persistent microtubule growth

(2009) Yulia Komarova et al.   JOURNAL OF CELL BIOLOGY

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model

(2009) Natalia Shiryaev et al.   NEUROBIOLOGY OF DISEASE

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Minocycline reduces the development of abnormal tau species in models of Alzheimer’s disease

(2008) Wendy Noble et al.   FASEB JOURNAL

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

(2008) Siddhartha Mondragón-Rodríguez et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

I PP2A 1 Affects Tau Phosphorylation via Association with the Catalytic Subunit of Protein Phosphatase 2A

(2008) She Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease

(2008) Y. Matsuoka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

(2008) A. Gómez-Ramos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Evolutionary toggling of the MAPT 17q21.31 inversion region

(2008) Michael C Zody et al.   NATURE GENETICS