Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models

Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo

(2013) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

Structure–activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors

(2011) Joydev K. Laha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evidence for Irreversible Inhibition of Glycogen Synthase Kinase-3β by Tideglusib

(2011) Juan Manuel Domínguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Lesions by Manganese and Extensive Damage by Iron After Injection into Rat Striatum or Hippocampus

(2010) W. N. Sloot et al.   JOURNAL OF NEUROCHEMISTRY

Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

(2010) D. Piedrahita et al.   JOURNAL OF NEUROSCIENCE

Cyclodextrins promote protein aggregation posing risks for therapeutic applications

(2009) Min S. Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease

(2009) Christopher J. Helal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Challenges in the conduct of disease-modifying trials in ad: Practical experience from a phase 2 trial of TAU-aggregation inhibitor therapy

(2009) C. Wischik et al.   Journal of Nutrition Health & Aging

FLEXIQuant: A Novel Tool for the Absolute Quantification of Proteins, and the Simultaneous Identification and Quantification of Potentially Modified Peptides

(2009) Sasha Singh et al.   JOURNAL OF PROTEOME RESEARCH

P2-377: A phase 2, double-blind, placebo-controlled study to evaluate the safety, tolerability, and effect on cognitive function of AL-108 after 12 weeks of intranasal administration in subjects with mild cognitive impairment

(2008) Donald E. Schmechel et al.   Alzheimers & Dementia