Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

(2016) José Manuel Mellado-Gil et al.   DIABETOLOGIA

PAX4 R192H and P321H polymorphisms in type 2 diabetes and their functional defects

(2016) Jatuporn Sujjitjoon et al.   JOURNAL OF HUMAN GENETICS

PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment

(2016) Yanqing Zhang et al.   MOLECULAR THERAPY

The Diagnostic Utility of PAX8 for Neuroendocrine Tumors

(2016) Jau-Yu Liau et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Aberrant mRNA splicing of paired box 4 (PAX4) IVS7-1G>A mutation causing maturity-onset diabetes of the young, type 9

(2015) Jatuporn Sujjitjoon et al.   ACTA DIABETOLOGICA

Pax factors in transcription and epigenetic remodelling

(2015) Alexandre Mayran et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pax genes in renal development, disease and regeneration

(2015) Richa Sharma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet

(2015) Petra I. Lorenzo et al.   Scientific Reports

Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker

(2015) Zeeshan Ahmad et al.   PLoS One

A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell

(2014) Jennifer R. Kulzer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pax genes: regulators of lineage specification and progenitor cell maintenance

(2014) J. A. Blake et al.   DEVELOPMENT

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

(2013) R. C. W. Ma et al.   DIABETOLOGIA

The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse Pancreas

(2013) Alan W. Hart et al.   PLoS One

Evolutionary History of Chordate PAX Genes: Dynamics of Change in a Complex Gene Family

(2013) Vanessa Rodrigues Paixão-Côrtes et al.   PLoS One

A New PAX8 Mutation Causing Congenital Hypothyroidism in Three Generations of a Family Is Associated with Abnormalities in the Urogenital Tract

(2013) Ana Carvalho et al.   THYROID

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Transcriptional Dominance of Pax7 in Adult Myogenesis Is Due to High-Affinity Recognition of Homeodomain Motifs

(2012) Vahab D. Soleimani et al.   DEVELOPMENTAL CELL

Defective PAX4 R192H transcriptional repressor activities associated with maturity onset diabetes of the young and early onset-age of type 2 diabetes

(2012) Suwattanee Kooptiwut et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Value of Islet 1 and PAX8 in identifying metastatic neuroendocrine tumors of pancreatic origin

(2012) Jamie Koo et al.   MODERN PATHOLOGY

Pax8 Detection in Well-Differentiated Pancreatic Endocrine Tumors

(2011) Carmen M. Jimenez Moreno et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

PAX8 is expressed in pancreatic well-differentiated neuroendocrine tumors and in extrapancreatic poorly differentiated neuroendocrine carcinomas in fine-needle aspiration biopsy specimens

(2011) Claudia M. Haynes et al.   CANCER CYTOPATHOLOGY

In Vivo Conditional Pax4 Overexpression in Mature Islet  -Cells Prevents Stress-Induced Hyperglycemia in Mice

(2011) K. H. H. He et al.   DIABETES

A common variant upstream of the PAX6 gene influences islet function in man

(2011) E. Ahlqvist et al.   DIABETOLOGIA

Co-orthology of Pax4 and Pax6 to the fly eyeless gene: molecular phylogenetic, comparative genomic, and embryological analyses

(2011) Tereza Manousaki et al.   EVOLUTION & DEVELOPMENT

Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors

(2011) Petra I. Lorenzo et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Association of variants in genes involved in pancreatic β-cell development and function with type 2 diabetes in North Indians

(2011) Sreenivas Chavali et al.   JOURNAL OF HUMAN GENETICS

PAX 8 expression in non-neoplastic tissues, primary tumors and metastatic tumors: a comprehensive immunohistochemical study

(2011) Ayhan Ozcan et al.   MODERN PATHOLOGY

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

(2011) Yoon Shin Cho et al.   NATURE GENETICS

A Novel PAX4 Mutation in a Japanese Patient with Maturity-Onset Diabetes of the Young

(2011) Wakako Jo et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Primary Extragastrointestinal Stromal Tumor of the Pleura: Report of a Unique Case With Genetic Confirmation

(2010) Kevin B. Long et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Relative roles of the different Pax6 domains for pancreatic alpha cell development

(2010) Petra Dames et al.   BMC DEVELOPMENTAL BIOLOGY

Impaired Glucose Tolerance and Insulin Resistance in Survivors of Childhood Acute Lymphoblastic Leukemia: Prevalence and Risk Factors

(2010) Pacharapan Surapolchai et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma

(2010) Ankur R Sangoi et al.   MODERN PATHOLOGY

KIT is an Independent Prognostic Marker for Pancreatic Endocrine Tumors

(2009) Lizhi Zhang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

ThePAX258gene subfamily: A comparative perspective

(2009) Debbie K. Goode et al.   DEVELOPMENTAL DYNAMICS

Analysis of Hypertrophic Thyrotrophs in Pituitaries of Athyroid Pax8−/−Mice

(2009) Jens Mittag et al.   ENDOCRINOLOGY

The Transcriptional Response of the Islet to Pregnancy in Mice

(2009) Sebastian Rieck et al.   MOLECULAR ENDOCRINOLOGY

Identification and characterization of four PAX8 rare sequence variants (p.T225M, p.L233L, p.G336S and p.A439A) in patients with congenital hypothyroidism and dysgenetic thyroid glands

(2008) Sebastián A. Esperante et al.   CLINICAL ENDOCRINOLOGY

Genome-Wide Linkage and Admixture Mapping of Type 2 Diabetes in African American Families From the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort

(2008) S. C. Elbein et al.   DIABETES

The association of the PAX4 gene with type 1 diabetes in Han Chinese

(2008) Yun Zhang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3)

(2008) J. H. Wen et al.   DIABETOLOGIA

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Pax6Haploinsufficiency Causes Abnormal Metabolic Homeostasis by Down-Regulating Glucagon-Like Peptide 1 in Mice

(2008) Jun Ding et al.   ENDOCRINOLOGY

Paxgenes in embryogenesis and oncogenesis

(2008) Qiuyu Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation

(2007) Deborah Lang et al.   MOLECULAR CARCINOGENESIS