Article
Surgery
Xu-Feng Zhang, Feng Xue, Zheng Wu, Alexandra G. Lopez-Aguiar, George Poultsides, Eleftherios Makris, Flavio Rocha, Zaheer Kanji, Sharon Weber, Alexander Fisher, Ryan Fields, Bradley A. Krasnick, Kamran Idrees, Paula M. Smith, Cliff Cho, Megan Beems, Yi Lyu, Shishir K. Maithel, Timothy M. Pawlik
Summary: This study aimed to improve the prognostic accuracy of pNETs by establishing and validating a new staging system. The eighth edition of AJCC staging system for pNETs failed to stratify patients effectively, while the proposed mTNM staging system showed better stratification based on long-term overall survival. This research has important implications for the treatment and prognosis evaluation of pNETs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seungchul Han, Jung Hoon Kim, Jeongin Yoo, Siwon Jang
Summary: The study revealed that MRI features such as size, enhancement pattern, vascular invasion, and ductal dilatation are useful in predicting recurrence and poor disease-free survival (DFS) after surgery in pancreatic neuroendocrine tumor (PNET) patients.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Anna Caterina Milanetto, Anna-Lea Gais Zurcher, Alina David, Matteo Fassan, Claudio Pasquali
Summary: This retrospective study evaluated the possible prognostic role of clinic-pathological features and surgery in pancreatic neuroendocrine neoplasms (pNENs). The results showed that about 20% of pNENs had a size > 4 cm, 78% were nonfunctioning, and 55% had distant metastases at diagnosis. However, long-term survival of more than five years can be achieved after surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Xu-Feng Zhang, Feng Xue, Ding-Hui Dong, Alexandra G. Lopez-Aguiar, George Poultsides, Eleftherios Makris, Flavio Rocha, Zaheer Kanji, Sharon Weber, Alexander Fisher, Ryan Fields, Bradley A. Krasnick, Kamran Idrees, Paula M. Smith, Cliff Cho, Megan Beems, Yi Lv, Shishir K. Maithel, Timothy M. Pawlik
Summary: The study found that both the number of metastatic lymph nodes and the minimum number of lymph nodes necessary for accurate staging play a crucial role in the prognosis of patients with pancreatic neuroendocrine tumors. Particularly for patients with lymph node metastasis, regional lymphadenectomy of at least 8 lymph nodes was necessary for accurate staging.
Article
Oncology
Xing Wang, Jia-Jun Qiu, Chun-Lu Tan, Yong-Hua Chen, Qing-Quan Tan, Shu-Jie Ren, Fan Yang, Wen-Qing Yao, Dan Cao, Neng-Wen Ke, Xu-Bao Liu
Summary: This study developed a quantitative nomogram that combines radiomic signatures with clinical characteristics to accurately predict the histology grade of pancreatic neuroendocrine tumors (PNETs) preoperatively.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Rosa Lynn Schmitz, Julia Weissbach, Jan Kleilein, Jessica Bell, Stefan Huettelmaier, Fabrice Viol, Till Clauditz, Patricia Grabowski, Helmut Laumen, Jonas Rosendahl, Patrick Michl, Joerg Schrader, Sebastian Krug
Summary: Pancreatic neuroendocrine tumors (PanNET) are rare and heterogeneous compared to pancreatic adenocarcinoma (PDAC). Various therapeutic approaches, including surgical resection, targeted therapy, and biotherapy, are applicable, but resistance to current therapies remains challenging. Recent research suggests targeting epigenetic modulators in neuroendocrine cells as a new therapeutic avenue, with studies showing potential functional effects and pathways affected.
Article
Pathology
Sarah E. Umetsu, Sanjay Kakar, Olca Basturk, Grace E. Kim, Deyali Chatterjee, Kwun Wah Wen, Gillian Hale, Na fis Sha, Soo-Jin Cho, Julia Whitman, Ryan M. Gill, Kirk D. Jones, Pooja Navale, Emily Bergsland, David Klimstra, Nancy M. Joseph
Summary: Distinguishing between grade 3 pancreatic neuroendocrine tumor (G3 PanNET) and neuroendocrine carcinoma (PanNEC) is a known diagnostic challenge. In this study, 47 high-grade neoplasms were reviewed, and molecular profiling was performed to improve diagnostic accuracy. The study found that molecular profiling and immunohistochemistry greatly improved the classification of high-grade pancreatic neuroendocrine neoplasms. Rating: 8/10.
Article
Oncology
Ophelie De Rycke, Thomas Walter, Marine Perrier, Olivia Hentic, Catherine Lombard-Bohas, Romain Coriat, Guillaume Cadiot, Anne Couvelard, Philippe Ruszniewski, Jerome Cros, Louis de Mestier
Summary: The study found that a pause followed by ALK rechallenge after the initial efficacy of ALK treatment may help prolong tumor control, improve quality of life, and limit long-term adverse events. The low efficacy of ALK rechallenge may be explained by increased MGMT expression under ALK.
ENDOCRINE-RELATED CANCER
(2021)
Article
Gastroenterology & Hepatology
Jia-Bei Liu, Qian-Biao Gu, Peng Liu
Summary: This case report presents a rare case of pancreatic inflammatory myofibroblastic tumor (IMT) that was initially clinically diagnosed as pancreatic neuroendocrine tumor but confirmed as pancreatic IMT by postoperative pathology. This report can help us better understand and correctly diagnose this disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Daisuke Takayanagi, Hourin Cho, Erika Machida, Atsushi Kawamura, Atsuo Takashima, Satoshi Wada, Takuya Tsunoda, Takashi Kohno, Kouya Shiraishi
Summary: This review provides updates on the epidemiology, diagnosis, and management of gastroenteropancreatic neuroendocrine neoplasms. The incidence of these malignancies originating from the pancreatic and gastrointestinal neuroendocrine cell system has been increasing. Advances in molecular diagnosis, treatment strategies, and liquid biopsy have contributed to personalized management for patients.
Review
Endocrinology & Metabolism
Yi Wu, Guangbing Xiong, Hang Zhang, Min Wang, Feng Zhu, Renyi Qin
Summary: This study analyzed the clinical features, diagnosis, therapy, and prognosis of ACTHoma. It was found that ACTHoma is more common in women, tumors are generally large, and common clinical manifestations include hypokalemia, diabetes, and weakness. These tumors are commonly found in the tail of the pancreas, with the liver being the most frequent site of metastasis.
ENDOCRINE PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Damian Jacenik, Eric J. Lebish, Ellen J. Beswick
Summary: The study demonstrates the important role of MK2 in PNETs, with its inhibition improving survival rates in mice and preventing disease progression. MK2 was also found to play a crucial role in regulating tumor metabolism and immune response, providing a new target for PNETs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
In Woong Han, Jangho Park, Eun Young Park, So Jeong Yoon, Gang Jin, Dae Wook Hwang, Kuirong Jiang, Wooil Kwon, Xuefeng Xu, Jin Seok Heo, De-Liang Fu, Woo Jung Lee, Xueli Bai, Yoo-Seok Yoon, Yin-Mo Yang, Keun Soo Ahn, Chunhui Yuan, Hyeon Kook Lee, Bei Sun, Eun Kyu Park, Seung Eun Lee, Sunghwa Kang, Wenhui Lou, Sang-Jae Park
Summary: No consensus has been reached on whether nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) ≤ 2 cm should be resected or observed. This study found that NF-pNETs ≤ 2 cm have a poor prognosis after resection if the tumor is larger than 1.5 cm, Ki-67 index >= 3%, or nodal metastasis is present. NF-pNET patients with tumors ≤ 1.5 cm can be observed if the preoperative Ki-67 index is < 3% and if nodal metastasis is not suspected in preoperative radiologic studies.
Article
Gastroenterology & Hepatology
Bokyung Ahn, Jin Kying Jung, HaeSung Jung, Yeon-Mi Ryu, Yeon Wook Kim, Tae Jun Song, Do Hyun Park, Dae Wook Hwang, HyungJun Cho, Sang-Yeob Kim, Seung-Mo Hong
Summary: Double Ki-Syn immunolabeling provides a more practical and easy method for evaluating Ki67LI in PanNETs from EUS-FNAB specimens. Compared with single Ki-67 immunolabeling, double Ki-Syn immunolabeling enables more accurate counting of proliferating tumor cells in PanNETs without including inflammatory and contaminant cells.
Article
Oncology
Iris N. Polee, Bregtje C. M. Hermans, Jan Maarten van der Zwan, Stefan A. W. Bouwense, Marcus W. Dercksen, Ferry A. L. M. Eskens, Bastiaan Havekes, Johannes Hofland, Thomas M. A. Kerkhofs, Heinz-Josef Klumpen, Loes M. Latten-Jansen, Ernst-Jan M. Speel, Frederik A. Verburg, Annemiek M. E. Walenkamp, Sandra M. E. Geurts, Judith de Vos-Geelen
Summary: This study aimed to assess the long-term survival and prognostic factors associated with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). The results demonstrate significant differences in survival based on different grades, tumour stages, and primary origins of GEP-NENs.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.