Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases

(2013) Melissa A. Pinard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship

(2013) Rui Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: an editorial

(2013) Claudiu T Supuran   EXPERT OPINION ON THERAPEUTIC PATENTS

Wirkmechanismen, klinisches Profil und Stellenwert von Carboanhydrasehemmern in der antiglaukomatösen Therapie

(2013) M. Eichhorn   KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: Implications for biological assembly and inhibitor development

(2012) Ewa S. Pilka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II

(2012) Rose Mikulski et al.   BIOCHEMISTRY

Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII

(2012) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insights towards sulfonamide drug specificity in α-carbonic anhydrases

(2012) Mayank Aggarwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural product coumarins that inhibit human carbonic anhydrases

(2012) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors

(2012) Emanuela Truppo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II

(2012) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-γ2

(2012) Maria C. Mitterberger et al.   EXPERIMENTAL CELL RESEARCH

Structural annotation of human carbonic anhydrases

(2012) Mayank Aggarwal et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

(2012) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Carbonic Anhydrase IX Interactome Reveals Proteins Assisting Its Nuclear Localization in Hypoxic Cells

(2012) Pasquale Buanne et al.   JOURNAL OF PROTEOME RESEARCH

In Vitro Evaluation of ESE-15-ol, an Estradiol Analogue with Nanomolar Antimitotic and Carbonic Anhydrase Inhibitory Activity

(2012) Barend Andre Stander et al.   PLoS One

Carbonic anhydrase isozymes II, IX, and XII in uterine tumors

(2011) PIRITTA HYNNINEN et al.   APMIS

N-β-Glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII

(2011) Oscar M. Rodríguez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors

(2011) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

(2011) Fabrizio Carta et al.   CHEMICAL COMMUNICATIONS

Design, Synthesis, and Biological Evaluation of Novel Carbohydrate-Based Sulfamates as Carbonic Anhydrase Inhibitors

(2011) Marie Lopez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase XIV in the normal and hypertrophic myocardium

(2011) Lorena A. Vargas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds

(2011) Katherine H. Sippel et al.   Letters in Drug Design & Discovery

Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis

(2011) Ming-Hsien Chien et al.   ORAL ONCOLOGY

A New Peptide Ligand for Targeting Human Carbonic Anhydrase IX, Identified through the Phage Display Technology

(2011) Vasileios Askoxylakis et al.   PLoS One

Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme

(2010) Fatemeh Bootorabi et al.   BIOCHIMIE

7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis

(2010) Kristiina Nordfors et al.   BMC CANCER

Perspectives on carbonic anhydrase

(2010) K.M. Gilmour   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Carbonic Anhydrase Related Protein VIII and its Role in Neurodegeneration and Cancer

(2010) Ashok Aspatwar et al.   CURRENT PHARMACEUTICAL DESIGN

Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12

(2010) Emad Muhammad et al.   HUMAN GENETICS

Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis

(2010) Marius I. Ilie et al.   INTERNATIONAL JOURNAL OF CANCER

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

(2010) P Swietach et al.   ONCOGENE

Antibody-specific detection of CAIX in breast and prostate cancers

(2009) Ying Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Short, Strong Hydrogen Bond in the Active Site of Human Carbonic Anhydrase II

(2009) Balendu Sankara Avvaru et al.   BIOCHEMISTRY

Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target

(2009) Giuseppina De Simone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure and catalytic mechanism of the β-carbonic anhydrases

(2009) Roger S. Rowlett   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II–trithiocarbonate adduct—An inhibitor mimicking the sulfonamide and urea binding to the enzyme

(2009) Claudia Temperini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

S-Glycosyl Primary Sulfonamides−A New Structural Class for Selective Inhibition of Cancer-Associated Carbonic Anhydrases

(2009) Marie Lopez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain

(2009) Marina Asiedu et al.   PAIN

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II

(2008) Esra Bayram et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein−Ligand Binding

(2008) Vijay M. Krishnamurthy et al.   CHEMICAL REVIEWS

Carbonic Anhydrases An Overview

(2008) Claudiu Supuran   CURRENT PHARMACEUTICAL DESIGN

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II

(2008) John F. Domsic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY