From Cancer to COVID‐19: A Perspective on Targeting Heparan Sulfate‐Protein Interactions

Inhibition of Tumor–Host Cell Interactions Using Synthetic Heparin Mimetics

(2021) Lukas M. Gockel et al.   ACS Applied Materials & Interfaces

Heparan Sulfate Mimetics Differentially Affect Homologous Chemokines and Attenuate Cancer Development

(2021) Chethan D. Shanthamurthy et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Protein Imager: a full-featured online molecular viewer interface with server-side HQ-rendering capabilities

(2020) Gianluca Tomasello et al.   BIOINFORMATICS

Brain Pathology in Mucopolysaccharidoses (MPS) Patients with Neurological Forms

(2020) Gustavo M. Viana et al.   Journal of Clinical Medicine

Heparanase, cell signaling, and viral infections

(2020) Raghuram Koganti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antitumor activity and structure-activity relationship of heparanase inhibitors: Recent advances

(2020) Kaishuo Fu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Continuous-Flow Accelerated Sulfation of Heparan Sulfate Intermediates

(2020) Saurabh Anand et al.   ORGANIC LETTERS

Sulfonated RAFT Copolymers as Heparin Mimetics: Synthesis, Reactivity Ratios, and Anticoagulant Activity

(2020) Abdullah Al Nahain et al.   MACROMOLECULAR BIOSCIENCE

Mapping the Structural and Dynamic Determinants of pH-Sensitive Heparin Binding to Granulocyte Macrophage Colony Stimulating Factor

(2020) Jennifer Y. Cui et al.   BIOCHEMISTRY

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

Modular Synthesis of Heparan Sulfate Oligosaccharides Having N-Acetyl and N-Sulfate Moieties

(2020) Lifeng Sun et al.   JOURNAL OF ORGANIC CHEMISTRY

Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides

(2020) Michelle C. Miller et al.   Scientific Reports

Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations

(2020) Julia A. Tree et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

(2020) Courtney J. Mycroft-West et al.   THROMBOSIS AND HAEMOSTASIS

Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545

(2019) Naphak Modhiran et al.   ANTIVIRAL RESEARCH

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation

(2019) Shravan Morla   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthetic Disaccharide Standards Enable Quantitative Analysis of Stored Heparan Sulfate in MPS IIIA Murine Brain Regions

(2019) Qi Qi He et al.   ACS Chemical Neuroscience

Fully Synthetic Heparan Sulfate-Based Neural Tissue Construct That Maintains the Undifferentiated State of Neural Stem Cells

(2019) Pradeep Chopra et al.   ACS Chemical Biology

Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly

(2019) Nitin J. Pawar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluating Heparin Products for Heparin-Induced Thrombocytopenia Using Surface Plasmon Resonance

(2019) Fuming Zhang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Chemoenzymatic Synthesis of Heparan Sulfate Mimetic Glycopolymers and Their Interactions with the Receptor for Advanced Glycation End-Product

(2019) Jun Li et al.   ACS Macro Letters

Heparanase: A Challenging Cancer Drug Target

(2019) Deirdre R. Coombe et al.   Frontiers in Oncology

Anticoagulant Heparin Mimetics via RAFT Polymerization

(2019) Abdullah Al Nahain et al.   BIOMACROMOLECULES

Prophylactic Antiheparanase Activity by PG545 Is Antiviral In Vitro and Protects against Ross River Virus Disease in Mice

(2018) Aroon Supramaniam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours

(2018) Keith Dredge et al.   BRITISH JOURNAL OF CANCER

Using structurally defined oligosaccharides to understand the interactions between proteins and heparan sulfate

(2018) Ding Xu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Heparin mimetics with anticoagulant activity

(2018) Abdullah Al Nahain et al.   MEDICINAL RESEARCH REVIEWS

Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors

(2018) Edward Hammond et al.   Journal for ImmunoTherapy of Cancer

Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice

(2018) Ravi S. Loka et al.   ACS Applied Materials & Interfaces

Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies

(2018) Daniel K. Afosah et al.   CURRENT MEDICINAL CHEMISTRY

The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard

(2018) Mohit Chhabra et al.   MOLECULES

Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity

(2018) Cinzia Lanzi et al.   MOLECULES

Targeting heparin and heparan sulfate protein interactions

(2017) Ryan J. Weiss et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Heparin-Mimicking Polymers: Synthesis and Biological Applications

(2016) Samantha J. Paluck et al.   BIOMACROMOLECULES

Chemical Synthesis of Glycosaminoglycans

(2016) Marco Mende et al.   CHEMICAL REVIEWS

Uncovering the Relationship between Sulphation Patterns and Conformation of Iduronic Acid in Heparan Sulphate

(2016) Po-Hung Hsieh et al.   Scientific Reports

Butanolysis Derivatization: Improved Sensitivity in LC-MS/MS Quantitation of Heparan Sulfate in Urine from Mucopolysaccharidosis Patients

(2015) Paul J. Trim et al.   ANALYTICAL CHEMISTRY

The Cholestanol-Conjugated Sulfated Oligosaccharide PG545 Disrupts the Lipid Envelope of Herpes Simplex Virus Particles

(2015) Joanna S. Said et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of new methods for determining the heparanase enzymatic activity

(2015) Carina Mucciolo Melo et al.   CARBOHYDRATE RESEARCH

The Interaction of Heparin Tetrasaccharides with Chemokine CCL5 Is Modulated by Sulfation Pattern and pH

(2015) Arunima Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan sulfate and heparin interactions with proteins

(2015) Maria C. Z. Meneghetti et al.   Journal of the Royal Society Interface

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Chemoenzymatic synthesis of heparan sulfate and heparin

(2014) Jian Liu et al.   NATURAL PRODUCT REPORTS

A simple method for early age phenotype confirmation using toe tissue from a mouse model of MPS IIIA

(2014) Paul J. Trim et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase

(2013) Jennifer C. Wilson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses

(2013) Vito Ferro   EXPERT OPINION ON THERAPEUTIC TARGETS

Conformations of the iduronate ring in short heparin fragments described by time-averaged distance restrained molecular dynamics

(2013) J. C. Munoz-Garcia et al.   GLYCOBIOLOGY

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors

(2012) Ligong Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of a Heparan Sulfate Mimetic Library Targeting FGF and VEGF via Click Chemistry on a Monosaccharide Template

(2012) Ligong Liu et al.   ChemMedChem

Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus

(2012) Joshua J. Ziarek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis

(2012) Vito Ferro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate

(2011) Anna Lundin et al.   ANTIVIRAL RESEARCH

Synthesis of simple heparanase substrates

(2011) Andrew G. Pearson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Overview of the mucopolysaccharidoses

(2011) J. Muenzer   RHEUMATOLOGY

Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1

(2010) Joanna Said et al.   ANTIVIRAL RESEARCH

A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus

(2010) Maria Ekblad et al.   ANTIVIRAL RESEARCH

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

(2010) Ken D. Johnstone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening

(2009) Edward Hammond et al.   ANALYTICAL BIOCHEMISTRY

An Improved Synthetic Route to the Potent Angiogenesis Inhibitor Benzyl Manα(1→3)-Manα(1→3)-Manα(1→3)-Manα(1→2)-Man Hexadecasulfate

(2009) Ligong Liu et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Synthesis of a heparan sulfate mimetic disaccharide with a conformationally locked residue from a common intermediate

(2009) Jon K. Fairweather et al.   CARBOHYDRATE RESEARCH

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

(2009) K. Dredge et al.   INVESTIGATIONAL NEW DRUGS

PI-88: a novel inhibitor of angiogenesis

(2008) Ragini Kudchadkar et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins

(2008) Siska Cochran et al.   GLYCOCONJUGATE JOURNAL

Heparin and low-molecular-weight heparin

(2008) Barbara Mulloy et al.   THROMBOSIS AND HAEMOSTASIS

Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88

(2007) Jon K. Fairweather et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides

(2007) Ligong Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS