Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

Cysteine cathepsins and extracellular matrix degradation

(2014) Marko Fonović et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Salvia miltiorrhiza: An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs

(2014) Yubo Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods

(2014) Marko Novinec et al.   Nature Communications

Allosteric inhibition of BACE1 by an exosite-binding antibody

(2013) Weiru Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RETRACTED: Odanacatib for the treatment of postmenopausal osteoporosis

(2013) Roland D Chapurlat   EXPERT OPINION ON PHARMACOTHERAPY

Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain

(2013) Enrico A. Stura et al.   FASEB JOURNAL

Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers

(2013) Preety Panwar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elastin Degradation by Cathepsin V Requires Two Exosites

(2013) Xin Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interstitial Collagen Catabolism

(2013) Gregg B. Fields   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Exosite-Targeting Inhibitors of Anthrax Lethal Factor by High-Throughput Screening

(2012) Ludovic Bannwarth et al.   CHEMISTRY & BIOLOGY

(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis

(2012) Alexander G. Dossetter et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1

(2012) S. W. Manka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet

(2011) Suowen Xu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Remote Exosites of the Catalytic Domain of Matrix Metalloproteinase-12 Enhance Elastin Degradation

(2011) Yan G. Fulcher et al.   BIOCHEMISTRY

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

(2011) Stephanie Dauth et al.   BMC NEUROSCIENCE

Structural Basis for Matrix Metalloproteinase 1-Catalyzed Collagenolysis

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis

(2011) Aline G. Costa et al.   Nature Reviews Rheumatology

Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?

(2010) Izabela Podgorski   Future Medicinal Chemistry

Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions

(2010) Maia M. Cherney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin K inhibitors for osteoporosis and potential off-target effects

(2009) Dieter Brömme et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cathepsin K generates enkephalin from β-endorphin: A new mechanism with possible relevance for schizophrenia

(2009) Uwe Lendeckel et al.   NEUROCHEMISTRY INTERNATIONAL

Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice

(2008) Andriy O. Samokhin et al.   ATHEROSCLEROSIS

The Correlation ofSalvia miltiorrhizaExtract–Induced Regulation of Osteoclastogenesis with the Amount of Components Tanshinone I, Tanshinone IIA, Cryptotanshinone, and Dihydrotanshinone

(2008) Hae-Kyung Kim et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

MMP-12 Catalytic Domain Recognizes Triple Helical Peptide Models of Collagen V with Exosites and High Activity

(2008) Rajagopalan Bhaskaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal and Molecular Structures of a Cathepsin K:Chondroitin Sulfate Complex

(2008) Zhenqiang Li et al.   JOURNAL OF MOLECULAR BIOLOGY