A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

(2015) Vidhu Sharma et al.   BIOCHEMICAL JOURNAL

Inhibition of bone resorption by the cathepsin K inhibitor odanacatib is fully reversible

(2014) Y. Zhuo et al.   BONE

TMEPAI inhibits TGF-β signaling by promoting lysosome degradation of TGF-β receptor and contributes to lung cancer development

(2014) Xilong Bai et al.   CELLULAR SIGNALLING

Treatment of postmenopausal osteoporosis with odanacatib

(2014) Roland D Chapurlat   EXPERT OPINION ON PHARMACOTHERAPY

Salvia miltiorrhiza: An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs

(2014) Yubo Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial

(2014) H. G. Bone et al.   OSTEOPOROSIS INTERNATIONAL

Structural basis of collagen fiber degradation by cathepsin K

(2014) Adeleke H. Aguda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications of Osteoblast-Osteoclast Interactions in the Management of Osteoporosis by Antiresorptive Agents Denosumab and Odanacatib

(2014) Natalie A. Sims et al.   Current Osteoporosis Reports

Steering the osteoclast through the demineralization–collagenolysis balance

(2013) Kent Søe et al.   BONE

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cathepsin K Inhibitors: A Novel Target but Promising Approach in the Treatment of Osteoporosis

(2013) Asadul Helali et al.   CURRENT DRUG TARGETS

Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers

(2013) Preety Panwar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elastin Degradation by Cathepsin V Requires Two Exosites

(2013) Xin Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification

(2013) Sergio Bertazzo et al.   NATURE MATERIALS

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis

(2012) Alexander G. Dossetter et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

(2011) Stephanie Dauth et al.   BMC NEUROSCIENCE

The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking

(2011) P. Leung et al.   BONE

Quantitative determination of odanacatib in human plasma using liquid–liquid extraction followed by liquid chromatography–tandem mass spectrometry analysis

(2011) Li Sun et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib

(2011) Thomas M. Rnger et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis

(2011) Aline G. Costa et al.   Nature Reviews Rheumatology

Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions

(2010) Maia M. Cherney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoids maintain human osteoclasts in the active mode of their resorption cycle

(2010) Kent Søe et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex

(2010) Christopher J. Linnevers et al.   PROTEIN SCIENCE

Expression and regulation of cathepsin K in skin fibroblasts

(2009) Maria J. Quintanilla-Dieck et al.   EXPERIMENTAL DERMATOLOGY

Cathepsin K inhibitors for osteoporosis and potential off-target effects

(2009) Dieter Brömme et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Endocytic regulation of TGF-β signaling

(2008) Ye-Guang Chen   CELL RESEARCH

The Crystal and Molecular Structures of a Cathepsin K:Chondroitin Sulfate Complex

(2008) Zhenqiang Li et al.   JOURNAL OF MOLECULAR BIOLOGY