Centipede venoms as a source of drug leads

Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides

(2016) Eivind A. B. Undheim et al.   BIOESSAYS

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Isolation of the Binding Protein of Periplocoside E from BBMVs in Midgut of the Oriental Amyworm Mythimna separata Walker (Lepidoptera: Noctuidae) through Affinity Chromatography

(2016) Mingxing Feng et al.   Toxins

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

(2015) Julie K Klint et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Tripeptide SQL Inhibits Platelet Aggregation and Thrombus Formation by Affecting PI3K/Akt Signaling

(2015) Xing-li Su et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptidomics combined with cDNA library unravel the diversity of centipede venom

(2015) Mingqiang Rong et al.   Journal of Proteomics

Neuropeptide W modulation of gastric vagal afferent mechanosensitivity: Impact of age and sex

(2015) Hui Li et al.   PEPTIDES

Production and packaging of a biological arsenal: Evolution of centipede venoms under morphological constraint

(2015) Eivind A. B. Undheim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins

(2015) Huaqun Zhang et al.   STRUCTURE

Scorpion venom components as potential candidates for drug development

(2015) Ernesto Ortiz et al.   TOXICON

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

(2015) Shilong Yang et al.   Nature Communications

A distinct three-helix centipede toxin SSD609 inhibits I ks channels by interacting with the KCNE1 auxiliary subunit

(2015) Peibei Sun et al.   Scientific Reports

Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors

(2015) Shaoqiong Xu et al.   Scientific Reports

Separation of Binding Protein of Celangulin V from the Midgut of Mythimna separata Walker by Affinity Chromatography

(2015) Lina Lu et al.   Toxins

No Gain, No Pain: NaV1.7 as an Analgesic Target

(2014) Glenn F. King et al.   ACS Chemical Neuroscience

Cytotoxic and anticoagulant peptide from Scolopendra subspinipes mutilans venom

(2014) Yi Kong   African Journal of Pharmacy and Pharmacology

Cystine-knot peptides: emerging tools for cancer imaging and therapy

(2014) Shelley E Ackerman et al.   Expert Review of Proteomics

Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity

(2014) Brad R Green et al.   Future Medicinal Chemistry

Spider venomics: implications for drug discovery

(2014) Sandy S Pineda et al.   Future Medicinal Chemistry

Isolation and characterization of SsmTx-I, a Specific Kv2.1 blocker from the venom of the centipedeScolopendra Subspinipes MutilansL. Koch

(2014) Minzhi Chen et al.   JOURNAL OF PEPTIDE SCIENCE

Proteomic characterization of the venom and transcriptomic analysis of the venomous gland from the Mexican centipede Scolopendra viridis

(2014) Lidia González-Morales et al.   Journal of Proteomics

Multifunctional warheads: Diversification of the toxin arsenal of centipedes via novel multidomain transcripts

(2014) Eivind A.B. Undheim et al.   Journal of Proteomics

Evaluating Topological Conflict in Centipede Phylogeny Using Transcriptomic Data Sets

(2014) Rosa Fernández et al.   MOLECULAR BIOLOGY AND EVOLUTION

Clawing through Evolution: Toxin Diversification and Convergence in the Ancient Lineage Chilopoda (Centipedes)

(2014) Eivind A.B. Undheim et al.   MOLECULAR BIOLOGY AND EVOLUTION

Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome

(2014) Tyler B. Tarr et al.   MOLECULAR NEUROBIOLOGY

Toxins and drug discovery

(2014) Alan L. Harvey   TOXICON

Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates

(2014) Bjoern von Reumont et al.   Toxins

The insecticidal potential of venom peptides

(2013) Jennifer J. Smith et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Novel Factor Xa-Inhibiting Peptide from Centipedes Venom

(2013) Yi Kong et al.   International Journal of Peptide Research and Therapeutics

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

(2013) Natali A. Minassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Variation in Gastric Vagal Afferent Mechanosensitivity

(2013) S. J. Kentish et al.   JOURNAL OF NEUROSCIENCE

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

(2013) Jefferson D. Revell et al.   PEPTIDES

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New calcium channel agonists as potential therapeutics in Lambert-Eaton myasthenic syndrome and other neuromuscular diseases

(2012) Tyler B. Tarr et al.   Annals of the New York Academy of Sciences

Spider-Venom Peptides: Structure, Pharmacology, and Potential for Control of Insect Pests

(2012) Glenn F. King et al.   Annual Review of Entomology

Cyclotides as a basis for drug design

(2012) David J Craik et al.   Expert Opinion on Drug Discovery

Characterization of the aqueous extract of the root of Aristolochia indica: Evaluation of its traditional use as an antidote for snake bites

(2012) Payel Bhattacharjee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chemical Punch Packed in Venoms Makes Centipedes Excellent Predators

(2012) Shilong Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

An L-Type Calcium Channel Agonist, Bay K8644, Extends the Window of Intervention Against Ischemic Neuronal Injury

(2012) Hong-hai Hu et al.   MOLECULAR NEUROBIOLOGY

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain

(2011) Christopher J. Bohlen et al.   NATURE

On the venom system of centipedes (Chilopoda), a neglected group of venomous animals

(2011) Eivind A.B. Undheim et al.   TOXICON

From snake venom toxins to therapeutics – Cardiovascular examples

(2011) Cho Yeow Koh et al.   TOXICON

Plasma nitroproteome of kidney disease patients

(2010) Marta Piroddi et al.   AMINO ACIDS

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

Peptide toxins that selectively target insect NaVand CaVchannels

(2010) Glenn F. King et al.   Channels

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Identification of glutamate 344 as the catalytic residue in the active site of pig heart CoA transferase

(2010) Jean-Christophe Rochet et al.   PROTEIN SCIENCE

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

(2009) Bryan G. Fry et al.   Annual Review of Genomics and Human Genetics

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

(2009) Belen Vaz et al.   CHEMICAL COMMUNICATIONS

Two novel antimicrobial peptides from centipede venoms

(2009) Kanfu Peng et al.   TOXICON

Animal Peptides Targeting Voltage-Activated Sodium Channels

(2008) Bert Billen et al.   CURRENT PHARMACEUTICAL DESIGN

Conus Venoms - A Rich Source of Peptide-Based Therapeutics

(2008) Tiffany Han et al.   CURRENT PHARMACEUTICAL DESIGN

Turning a Scorpion Toxin into an Antitumor Miniprotein

(2008) Chong Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY