Drug resistance reversal by interventing cancer bioenergetics with spherical helical polypeptide-potented gene silencing

Dendronized‐Polymer Disturbing Cells' Stress Protection by Targeting Metabolism Leads to Tumor Vulnerability

(2020) Dayi Pan et al.   ADVANCED MATERIALS

Fluorinated α-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration toward Highly Efficient Pulmonary siRNA Delivery against Acute Lung Injury

(2020) Chenglong Ge et al.   NANO LETTERS

A Nanostrategy for Efficient Imaging‐Guided Antitumor Therapy through a Stimuli‐Responsive Branched Polymeric Prodrug

(2020) Hao Cai et al.   Advanced Science

Homologous-targeting biomimetic nanoparticles for photothermal therapy and Nrf2-siRNA amplified photodynamic therapy against oral tongue squamous cell carcinoma

(2020) Shurui Shi et al.   CHEMICAL ENGINEERING JOURNAL

Engineering Magnetosomes with Chimeric Membrane and Hyaluronidase for Efficient Delivery of HIF-1 siRNA into Deep Hypoxic Tumors

(2020) Chengliang Lyu et al.   CHEMICAL ENGINEERING JOURNAL

iRGD-reinforced, photo-transformable nanoclusters toward cooperative enhancement of intratumoral penetration and antitumor efficacy

(2020) Jing Yan et al.   Nano Research

Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters

(2020) Jing Yan et al.   BIOMATERIALS

Investigating the EPR effect of nanomedicines in human renal tumors via ex vivo perfusion strategy

(2020) Yuxun Ding et al.   Nano Today

Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor

(2019) Soo Zeng Fiona Phua et al.   ACS Nano

Mitochondrial Surface Engineering for Multidrug Resistance Reversal

(2019) Wei Chen et al.   NANO LETTERS

A novel chitosan-based nanomedicine for multi-drug resistant breast cancer therapy

(2019) Shiwei Niu et al.   CHEMICAL ENGINEERING JOURNAL

Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism

(2019) Juanjuan Dang et al.   BIOMATERIALS

Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy

(2018) Jun Zhou et al.   ACS Nano

Stepwise Degradable Nanocarriers Enabled Cascade Delivery for Synergistic Cancer Therapy

(2018) Yannan Yang et al.   ADVANCED FUNCTIONAL MATERIALS

Effective and Selective Anti-Cancer Protein Delivery via All-Functions-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering

(2018) Hua He et al.   ADVANCED FUNCTIONAL MATERIALS

Photoresponsive Drug/Gene Delivery Systems

(2018) Yang Zhou et al.   BIOMACROMOLECULES

Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer

(2018) Ranran Zhao et al.   BIOMATERIALS

Photoinduced PEG deshielding from ROS-sensitive linkage-bridged block copolymer-based nanocarriers for on-demand drug delivery

(2018) Jie Li et al.   BIOMATERIALS

Noncovalent tagging of siRNA with steroids for transmembrane delivery

(2018) Wanyi Tai et al.   BIOMATERIALS

Evaluating the Mechanisms of Light-Triggered siRNA Release from Nanoshells for Temporal Control Over Gene Regulation

(2018) Rachel S. Riley et al.   NANO LETTERS

Repolarization of Tumor-Associated Macrophages in a Genetically Engineered Nonsmall Cell Lung Cancer Model by Intraperitoneal Administration of Hyaluronic Acid-Based Nanoparticles Encapsulating MicroRNA-125b

(2018) Neha N. Parayath et al.   NANO LETTERS

Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

(2018) Hong-Xia Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorinated Oligoethylenimine Nanoassemblies for Efficient siRNA-Mediated Gene Silencing in Serum-Containing Media by Effective Endosomal Escape

(2018) Tingbin Zhang et al.   NANO LETTERS

Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug

(2018) Amit Sharma et al.   Chem

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

Tumor-Specific Multiple Stimuli-Activated Dendrimeric Nanoassemblies with Metabolic Blockade Surmount Chemotherapy Resistance

(2016) Yachao Li et al.   ACS Nano

Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles

(2016) Hua He et al.   ACS Nano

Co-delivery of Se nanoparticles and pooled SiRNAs for overcoming drug resistance mediated by P-glycoprotein and class III β-tubulin in drug-resistant breast cancers

(2016) Wenjing Zheng et al.   Acta Biomaterialia

Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing

(2016) Samantha M. Sarett et al.   BIOMATERIALS

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy

(2016) Madhusudhanan Sukumar et al.   Cell Metabolism

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

Tumor-Triggered Drug Release with Tumor-Targeted Accumulation and Elevated Drug Retention To Overcome Multidrug Resistance

(2016) Wei-Hai Chen et al.   CHEMISTRY OF MATERIALS

Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies

(2016) Wen Li et al.   DRUG RESISTANCE UPDATES

In vitro and ex vivo strategies for intracellular delivery

(2016) Martin P. Stewart et al.   NATURE

Green Tea Catechin-Based Complex Micelles Combined with Doxorubicin to Overcome Cardiotoxicity and Multidrug Resistance

(2016) Tangjian Cheng et al.   Theranostics

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

(2015) Valeria Iansante et al.   Nature Communications

Comparative α-Helicity of Cyclic Pentapeptides in Water

(2014) Aline D. de Araujo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides

(2014) Rujing Zhang et al.   BIOMATERIALS

Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics

(2014) Jianliang Shen et al.   Theranostics

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

(2011) Inthrani R. Indran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen species

(2011) Luisa Lo Iacono et al.   FREE RADICAL BIOLOGY AND MEDICINE