Safety assessment of nanoparticles for drug delivery by means of classicin vitroassays and beyond

Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

(2016) Hyeonjeong Jeon et al.   JOURNAL OF CONTROLLED RELEASE

A combined proteomics and metabolomics approach to assess the effects of gold nanoparticlesin vitro

(2016) Sabrina Gioria et al.   Nanotoxicology

Imaging mitochondrial reactive oxygen species with fluorescent probes: Current applications and challenges

(2015) X. Zhang et al.   FREE RADICAL RESEARCH

Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

(2015) A.A. Stepanenko et al.   GENE

Surface coating mediates the toxicity of polymeric nanoparticles towards human-like macrophages

(2015) Nadège Grabowski et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Biodegradable Particulate Carrier Formulation and Tuning for Targeted Drug Delivery

(2015) Salma N. Tammam et al.   Journal of Biomedical Nanotechnology

Biodistribution, Clearance, and Toxicology of Polymeric Micelles Loaded with 0.9 or 5 nm Gold Nanoparticles

(2015) Ajlan Al Zaki et al.   Journal of Biomedical Nanotechnology

Toxicity of Raw and Purified Single-Walled Carbon Nanotubes in Rat's Lung Epithelial and Cervical Cancer Cells

(2015) Virupaxi Goornavar et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Human Monocyte Response to S-Nitrosoglutathione-Loaded Nanoparticles: Uptake, Viability, and Transcriptome

(2015) Ramia Safar et al.   MOLECULAR PHARMACEUTICS

Nanoparticles as drug carriers: current issues within vitrotesting

(2015) Maryam Alsadat Shetab Boushehri et al.   Nanomedicine

Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions

(2015) Linda C. Stoehr et al.   Particle and Fibre Toxicology

Changes in Caco-2 cells transcriptome profiles upon exposure to gold nanoparticles

(2015) Edyta Bajak et al.   TOXICOLOGY LETTERS

Viability and gene expression responses to polymeric nanoparticles in human and rat cells

(2014) Carole Ronzani et al.   CELL BIOLOGY AND TOXICOLOGY

Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers – A systematic review of in vitro data

(2014) Slavomira Doktorovova et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages

(2014) Matthias Bartneck et al.   Nanomedicine-Nanotechnology Biology and Medicine

Intestinal absorption of insulin nanoparticles: Contribution of M cells

(2014) Marlene Almeida Lopes et al.   Nanomedicine-Nanotechnology Biology and Medicine

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis

(2014) Junchao Duan et al.   Particle and Fibre Toxicology

Carboxylated Short Single-Walled Carbon Nanotubes But Not Plain and Multi-Walled Short Carbon Nanotubes Show in vitro Genotoxicity

(2014) Maria Mrakovcic et al.   TOXICOLOGICAL SCIENCES

A proteomic approach to investigate AuNPs effects in Balb/3T3 cells

(2014) Sabrina Gioria et al.   TOXICOLOGY LETTERS

The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes

(2013) Changhui Fu et al.   BIOMATERIALS

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

Toxicity of surface-modified PLGA nanoparticles toward lung alveolar epithelial cells

(2013) Nadège Grabowski et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Assessment of the in vitro γH2AX assay by High Content Screening as a novel genotoxicity test

(2013) Carolina Garcia-Canton et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Raman spectroscopy in nanomedicine: current status and future perspective

(2013) Mark E Keating et al.   Nanomedicine

Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classicin vitrotests

(2013) Rina Guadagnini et al.   Nanotoxicology

Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells

(2013) Rina Guadagnini et al.   Nanotoxicology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Accumulated Polymer Degradation Products as Effector Molecules in Cytotoxicity of Polymeric Nanoparticles

(2013) Raman Preet Singh et al.   TOXICOLOGICAL SCIENCES

Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: A quantitative method for oxidative stress assessment of nanoparticle-treated cells

(2013) A. Aranda et al.   TOXICOLOGY IN VITRO

The genotoxicity of PEI-based nanoparticles is reduced by acetylation of polyethylenimine amines in human primary cells

(2013) Anna Calarco et al.   TOXICOLOGY LETTERS

Liposome: classification, preparation, and applications

(2013) Abolfazl Akbarzadeh et al.   Nanoscale Research Letters

Biocompatibility assessment of Si-based nano- and micro-particles

(2012) Hamsa Jaganathan et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid nanoparticles: state of the art, new preparation methods and challenges in drug delivery

(2012) Luigi Battaglia et al.   Expert Opinion on Drug Delivery

Nanoparticle-based clodronate delivery mitigates murine experimental colitis

(2012) Wiebke Niebel et al.   JOURNAL OF CONTROLLED RELEASE

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Genotoxicity testing of PLGA–PEO nanoparticles in TK6 cells by the comet assay and the cytokinesis-block micronucleus assay

(2012) Alena Kazimirova et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Transepithelial transport and toxicity of PAMAM dendrimers: Implications for oral drug delivery

(2011) S. Sadekar et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

(2011) Laura M. Ensign et al.   ADVANCED DRUG DELIVERY REVIEWS

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drug delivery by polymeric nanoparticles induces autophagy in macrophages

(2011) H. Eidi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker

(2011) Lisa M. Kaminskas et al.   JOURNAL OF CONTROLLED RELEASE

Different Effects of Bromodeoxyuridine and [3H]Thymidine Incorporation into DNA on Cell Proliferation, Position, and Fate

(2011) A. Duque et al.   JOURNAL OF NEUROSCIENCE

Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells

(2011) Mary-Line Jugan et al.   Nanotoxicology

Validation of an LDH assay for assessing nanoparticle toxicity

(2011) Xianglu Han et al.   TOXICOLOGY

Toxicity assessment of nanomaterials: methods and challenges

(2010) Alok Dhawan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Characterization of PicoGreen Interaction with dsDNA and the Origin of Its Fluorescence Enhancement upon Binding

(2010) A.I. Dragan et al.   BIOPHYSICAL JOURNAL

Secondary cytotoxicity mediated by alveolar macrophages: A contribution to the total efficacy of nanoparticles in lung cancer therapy?

(2010) Kamal M.H.D Al-Hallak et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Cytotoxicity assessment of heparin nanoparticles in NR8383 macrophages

(2010) H. Eidi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mass spectrometry–based proteomics in cell biology

(2010) Tobias C. Walther et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Nanomaterial cytotoxicity is composition, size, and cell type dependent

(2010) Syed K Sohaebuddin et al.   Particle and Fibre Toxicology

Uptake and cytotoxicity of chitosan nanoparticles in human liver cells

(2010) Jing Wen Loh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro assessments of nanomaterial toxicity

(2009) Clinton F. Jones et al.   ADVANCED DRUG DELIVERY REVIEWS

NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials

(2009) Neenu Singh et al.   BIOMATERIALS

Addressing the problem of cationic lipid-mediated toxicity: The magnetoliposome model

(2009) Stefaan J.H. Soenen et al.   BIOMATERIALS

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity

(2009) Elodie Boisselier et al.   CHEMICAL SOCIETY REVIEWS

Carbon black and titanium dioxide nanoparticles induce pro-inflammatory responses in bronchial epithelial cells: Need for multiparametric evaluation due to adsorption artifacts

(2009) Stéphanie Val et al.   INHALATION TOXICOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

(2008) Guillermo Repetto et al.   Nature Protocols

Cytotoxicity of Nanoparticles

(2007) Nastassja Lewinski et al.   Small