Article
Biochemistry & Molecular Biology
Mingze Xu, Jinpeng Huang, Siyuan Jiang, Jiecheng He, Zhen Wang, Han Qin, Yan-Qing Guan
Summary: Compared with injection, oral drug delivery is a preferred mode of administration due to its security, low pain, and simplicity. In this study, a targeted oral delivery system was developed using ConA-INS-KGM nanoparticles loaded with insulin, which demonstrated reversible glucose-responsive insulin release and high biocompatibility. These nanoparticles show significant potential for diabetes treatment and have various applications in biomedical fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Patrik Lundquist, Georgiy Khodus, Zhigao Niu, Lungile Nomcebo Thwala, Fiona McCartney, Ivailo Simoff, Ellen Andersson, Ana Beloqui, Aloise Mabondzo, Sandra Robla, Dominic-Luc Webb, Per M. Hellstroem, asa Keita, Eduardo Sima, Noemi Csaba, Magnus Sundbom, Veronique Preat, David J. Brayden, Maria Jose Alonso, Per Artursson
Summary: Peptide drugs are not orally bioavailable due to their poor stability and permeability, but nanoparticle formulations may provide a solution. In this study, the absorption mechanisms of four insulin-loaded arginine-rich nanoparticles were investigated. One nanoparticle showed significant uptake and is proposed for further investigation for local delivery.
Review
Pharmacology & Pharmacy
Carlynne Choy, Lee Yong Lim, Lai Wah Chan, Zhixiang Cui, Shirui Mao, Tin Wui Wong
Summary: This review examines the potential of targeting intestinal receptors to improve the oral delivery of nanoinsulin. While promising, further research and optimization are needed.
PHARMACOLOGICAL REVIEWS
(2022)
Review
Biotechnology & Applied Microbiology
Yang-Bao Miao, Tianxing Xu, Ying Gong, Anmei Chen, Liang Zou, Tao Jiang, Yi Shi
Summary: Oral administration is the preferred method of drug delivery due to its safety and high patient compliance, but it is limited by poor bioavailability. This review discusses the targeted drug vehicles to the intestinal lymphatic system (ILS) and their significance in medication absorption and transport. The review presents various approaches to targeting the ILS for enhanced bioavailability and targeted delivery, as well as methods for opening the ILS window for potential clinical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ziyue Xi, Ejaj Ahmad, Wei Zhang, Jingyi Li, Aohua Wang, Faridoon, Ning Wang, Chunliu Zhu, Wei Huang, Lu Xu, Miaorong Yu, Yong Gan
Summary: By constructing a functional nanoparticle with dual-modification, this study addressed the absorption barriers for oral insulin delivery, improving its bioavailability and hypoglycemic effect. The formulation demonstrates the potential of oral macromolecule delivery by overcoming multiple gastrointestinal barriers with a simple dual-modification strategy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Mengjie Wang, Chunxin Wang, Shuaikai Ren, Junqian Pan, Yan Wang, Yue Shen, Zhanghua Zeng, Haixin Cui, Xiang Zhao
Summary: Diabetes is a chronic metabolic disease characterized by lack of insulin in the body. Developing oral insulin formulations is a hot and difficult topic in medicine and pharmacy to improve patients' adaptability and reduce injection pain. However, oral insulin faces challenges such as degradation, low bioavailability, and hydrophilicity. To overcome these obstacles, researchers have designed and constructed oral insulin delivery nanosystems using nanomaterials and technology. These systems have advantages in adaptability, size, processing, pharmaceutical activity, and controlled release, effectively improving the oral bioavailability and efficacy of insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jae Geun Song, Sang Hoon Lee, Hyo-Kyung Han
Summary: The study aimed at developing an M cell targeted-nanocomposite delivery system for protein drugs to overcome absorption barriers in the GI tract, and showed promising results in improving the bioavailability of orally administered protein drugs in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Chemistry, Medicinal
Maisarah Azman, Akmal H. Sabri, Qonita Kurnia Anjani, Mohd Faiz Mustaffa, Khuriah Abdul Hamid
Summary: The oral route is the most common and practical means of drug administration. However, drug absorption through the intestinal wall is influenced by various factors, including the presence of efflux transporters, enzymatic degradation, and tight junctions. Hydrophilic drugs, high molecular weight drugs, and efflux transporter substrates face more challenges in terms of absorption. Another challenge is first-pass hepatic metabolism, which can reduce drug bioavailability. Various compounds have been studied for their permeation-enhancing effects, and nanocarrier-based formulations have also gained interest in enhancing oral drug absorption.
Article
Nanoscience & Nanotechnology
Xia Huang, Shangcong Han, Zuxian Chen, Lei Zhao, Changduo Wang, Qingyang Guo, Yanfeng Li, Yong Sun
Summary: LDH nanoparticles modified by DCA and HA improved the absorption efficiency of insulin by opening the TJs of cells and interacting with the cholic acid transporter receptor protein.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Zichen Zhang, Yi Lu, Jianping Qi, Wei Wu
Summary: Orally administered drugs must survive the gastrointestinal environment, penetrate the enteric epithelia, and avoid hepatic metabolism before reaching the systemic circulation. Hepatic metabolism is a significant barrier, and alternative pathways like intestinal lymphatic transport are being explored. Main pathways for peroral lymphatic transport include the chylomicron and microfold cell pathways, with increasing research input and applications.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Engineering, Biomedical
Weizhi Wang, Chenggong Yu, Fangfang Zhang, Yuxuan Li, Bo Zhang, Jie Huang, Zhijun Zhang, Liang Jin
Summary: A drug delivery system, GC-CA@PLGA NPs, has been developed to improve the oral administration of insulin with excellent stability, good biocompatibility, and significantly increased bioavailability for potential application in the treatment of diabetes.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Medicinal
Mai Itagaki, Noriyasu Kamei, Mariko Takeda-Morishita
Summary: This study evaluated human induced pluripotent stem cell-derived small intestinal epithelial cells (hiPSC-SIECs) as a new model for predicting intestinal drug absorption. The results showed that hiPSC-SIECs are more suitable for predicting the absorption of peptide drugs compared to Caco-2 cells, require divalent cations for barrier integrity, and have different responses to absorption enhancers than Caco-2 cells.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Jeong Man An, S. M. Shatil Shahriar, Yong Hwa Hwang, Seung Rim Hwang, Dong Yun Lee, Sungpil Cho, Yong-kyu Lee
Summary: The triple padlock nanocarrier designed for oral delivery of recombinant human teriparatide showed promising therapeutic effects against osteoporosis in OVX rats by recovering bone marrow density, serum bone parameters, and promoting new bone formation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Yiming He, Yihong Huang, Huahua Xu, Xufeng Yang, Nan Liu, Yongxin Xu, Renhuan Ma, Junqiu Zhai, Yan Ma, Shixia Guan
Summary: There is a strong need for non-invasive and highly compliant delivery systems for long-term therapy of macromolecules. Oral administration of macromolecules is impeded by low permeability and instability in the GI tract. In this study, we developed aptamer-modified liposomes (Apt-Lip) targeting M cells for oral delivery of exenatide (EXT). Apt-Lip showed enhanced cell uptake and transport efficiency of EXT in M cells, and exhibited high intestinal absorption and M cell-specific targeting capacity in ex vivo intestinal absorption study. Therefore, Apt-Lip holds promise as a targeted delivery system for oral administration of macromolecules.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
Xiomara Calderon-Colon, Yichuan Zhang, Olivia Tiburzi, Jialu Wang, Shenda Hou, Giorgio Raimondi, Julia Patrone
Summary: A nanostructured lipid carrier (NLC) containing insulin peptide was designed and formulated for oral delivery using the design of experiments (DOE) statistical method. The study found that the particles had good biocompatibility, were readily taken up by immune cells in vitro, and accumulated in regional lymph nodes after oral administration. This platform technology has potential for the development of oral delivery-based antigen specific immunotherapies for autoimmune diseases.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Thermodynamics
Luis M. P. Verissimo, Ines Cabral, Ana M. T. D. P. V. Cabral, Gianluca Utzeri, Francisco J. B. Veiga, Artur J. M. Valente, Ana C. F. Ribeiro
Summary: The paper discusses the transport properties of 5-fluorouracil and highlights the importance of precise dosing in cancer pharmacology. Experimental data is used to calculate descriptive parameters and provide further interpretation based on established models.
JOURNAL OF CHEMICAL THERMODYNAMICS
(2021)
Review
Pharmacology & Pharmacy
Izabela B. C. Lima, Lina Clara. G. A. I. Moreno, Edson C. Silva-Filho, Juan M. Irache, Francisco J. B. Veiga, Hercilia M. L. Rolim, Livio C. C. Nunes
Summary: Inflammatory bowel disease is a chronic condition with symptoms such as diarrhea, abdominal pain, weight loss, rectal bleeding, and anemia. Nanosystems, particularly those utilizing chitosan as the main polymer, show potential in optimizing treatment by increasing drug absorption and reaching the inflamed colon effectively. Although studies in this area are still relatively new, they demonstrate promising therapeutic benefits.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Diana Peixoto, Irina Pereira, Miguel Pereira-Silva, Francisco Veiga, Michael R. Hamblin, Yuri Lvov, Mingxian Liu, Ana Claudia Paiva-Santos
Summary: Nanoclays with tunable properties, such as physicochemical, morphological, and structural, show potential as multifunctional biocompatible nanocarriers for versatile applications in cancer research, diagnosis, and therapy.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Engineering, Biomedical
Miguel Pereira-Silva, Ana Margarida Martins, Ines Sousa-Oliveira, Helena Margarida Ribeiro, Francisco Veiga, Joana Marto, Ana Claudia Paiva-Santos
Summary: This review focuses on the breakthrough of nanomaterials in hair care and treatment, highlighting their potential as innovative multifunctional nanomaterials.
ACTA BIOMATERIALIA
(2022)
Article
Pharmacology & Pharmacy
Ana Santos, Catia Domingues, Ivana Jarak, Francisco Veiga, Ana Figueiras
Summary: Osteosarcoma (OS) is the most common primary malignant tumor of bone in children. Nanotechnology has developed exosomes as drug delivery systems that can release drugs directly at the tumor cells and reduce their toxicity.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Bruno Costa, Beatriz Boueri, Claudia Oliveira, Isabel Silveira, Antonio J. Ribeiro
Summary: This article reviews the major barriers of lipid and polymer delivery systems and provides an outline of preclinical assays under physiological conditions. Expert opinion suggests that closer mimicking of the in vivo environment in vitro experiments may provide more accurate results, and clinical practice would benefit from safer non-viral vectors.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
J. G. B. De Marchi, R. Ce, G. Onzi, A. C. S. Alves, N. Santarem, A. Cordeiro da Silva, A. R. Pohlmann, S. S. Guterres, A. J. Ribeiro
Summary: This study aims to improve the absorption of nanoparticle formulation by functionalizing its surface with immunoglobulin G. The functionalized nanoparticles showed adequate size and good entrapment efficiency, and led to a desirable increase in insulin release time. Interactions of nanoparticle components were proven through differential scanning calorimetry, infrared spectroscopy, and paper chromatography.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
A. C. Santos, J. Marto, R. Cha-Cha, A. M. Martins, M. Pereira-Silva, H. M. Ribeiro, F. Veiga
Summary: Sun protection is essential for preventing the damaging effects of solar UV radiation, with sunscreen formulations incorporating nanosystems showing improved efficiency and safety. This review discusses the use of various nanosystems like nanoemulsions, liposomes, and solid lipid nanoparticles in sunscreens, as well as the potential impacts on human health and regulatory approaches worldwide.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Filipa Mascarenhas-Melo, Maria Beatriz S. Goncalves, Diana Peixoto, Kiran D. Pawar, Victoria Bell, Vivek P. Chavda, Hajra Zafar, Faisal Raza, Ana Claudia Paiva-Santos, Ana Claudia Paiva-Santos
Summary: Diabetic wounds are a common health issue worldwide, and nanotechnology has emerged as a promising tool in their treatment. Nanosystems loaded with various active ingredients have shown improved properties and can effectively promote wound healing, angiogenesis, and synthesis of extracellular matrix compounds. Despite limitations, nanotechnology has gained significant attention and is considered valuable in the treatment and dressing of diabetic wounds.
JOURNAL OF DRUG TARGETING
(2022)
Article
Biochemistry & Molecular Biology
Alessandra R. Freitas, Antonio J. Ribeiro, Alessandra B. Ribeiro, Maria Del Mar Collado-Gonzalez, Luis R. Silva, Luis Alves, Elodie Melro, Filipe E. Antunes, Francisco Veiga, Alan I. S. Morais, Roosevelt D. S. Bezerra, Jose L. Soares-Sobrinho, Josy A. Osajima, Edson C. Silva-Filho
Summary: The present work aimed to modify the exuded gum of Sterculia striata tree through an amination reaction. The viscosity and zero potential of the chicha gum varied with pH. The modification was confirmed by various analytical techniques, and the modified gum showed increased mucoadhesive and inhibitory activity against Staphylococcus aureus, as well as antioxidant capacity and inhibitory effect against alpha-glucosidase.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
A. S. Sousa, J. Serra, C. Estevens, R. Costa, A. J. Ribeiro
Summary: This article provides an overview of quality by design (QbD) concepts and machine learning (ML) techniques applied to oral extended release (ER) delivery systems. QbD can improve product quality and reduce postapproval changes, while ML can be used to predict and optimize formulation and process development. However, there are challenges and barriers to adopting QbD.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
J. Simao, S. A. Chaudhary, A. J. Ribeiro
Summary: Bilayer tablets provide various drug release profiles and help prevent physicochemical incompatibilities between drugs and excipients. Successful manufacturing of these complex dosage forms requires optimization of material attributes and processing parameters, and strict monitoring and control of unit operations. Applying Quality by Design (QbD) principles can ensure the design and development of bilayer tablets meet quality requirements.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
B. Rama, A. J. Ribeiro
Summary: This article presents a systematic study of the application of nanosystems in highly prevalent chronic diseases, summarizing the advantages, limitations, and strategies for improving their translation into clinical applications. The potential contribution of quality-by-design (QbD) and artificial intelligence (AI) to the pharmaceutical development of nanosystems is also highlighted. However, the lack of standardized methodologies and evaluation guidelines hinders their access to clinical trials, calling for urgent development in this area.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Chemistry, Medicinal
Bruno Pessoa, Mar Collado-Gonzalez, Giuseppina Sandri, Antonio Ribeiro
Summary: This study aimed to optimize a nanoparticle formulation for orally delivered insulin by assessing the relationship between design parameters and experimental data using response surface methodology. The results showed that a nanoparticle formulation with 0.03% PEG, 0.047% chitosan, and 1.20% albumin provided an optimal solution for insulin oral delivery, maintaining insulin bioactivity in simulated intestinal media.
Article
Pharmacology & Pharmacy
A. S. Sousa, J. Serra, C. Estevens, R. Costa, A. J. Ribeiro
Summary: This study aims to evaluate the application of commonly used excipients in extended release formulations by analyzing their physical, compaction, and tablet properties, and their correlations with powder properties and mechanical properties, providing effective tools and methods for the development and manufacturing of direct compression-based extended release formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
