Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells

Increased O-GlcNAcylation of c-Myc Promotes Pre-B Cell Proliferation

(2020) Da Hee Lee et al.   Cells

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

(2020) Noemi A. Zambetti et al.   BLOOD

Membrane disruption, but not metabolic rewiring, is the key mechanism of anticancer-action of FASN-inhibitors: a multi-omics analysis in ovarian cancer

(2020) Thomas W. Grunt et al.   Scientific Reports

Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract

(2020) Maryam Harouni Ghaeidamini et al.   Scientific Reports

Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation

(2019) Louis Masclef et al.   Frontiers in Endocrinology

mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma

(2019) Ting Li et al.   Cell Death & Disease

Hyperglycemia and aberrant O-GlcNAcylation: contributions to tumor progression

(2018) Andréia Vasconcelos-dos-Santos et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cross regulation between mTOR signaling and O-GlcNAcylation

(2018) Ninon Very et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

(2018) Ulrike Bruning et al.   Cell Metabolism

O-GlcNAc transferase associates with the MCM2–7 complex and its silencing destabilizes MCM–MCM interactions

(2018) Maïté Leturcq et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Many Ways by Which O-GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations

(2018) James Biwi et al.   MOLECULES

Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription

(2017) Cecilia Patitucci et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

(2017) Renate Wagner et al.   Oncotarget

G protein-coupled receptors as promising cancer targets

(2016) Ying Liu et al.   CANCER LETTERS

The Nutrient-Dependent O -GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase

(2016) Steffi F. Baldini et al.   JOURNAL OF MOLECULAR BIOLOGY

Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling

(2016) Mingzuo Jiang et al.   Oncotarget

PI3K and AKT: Unfaithful Partners in Cancer

(2015) Seraina Faes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer

(2015) V. L. Sodi et al.   MOLECULAR CANCER RESEARCH

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)

(2015) Daorong Feng et al.   PLoS One

Novel Nuclear Localization of Fatty Acid Synthase Correlates with Prostate Cancer Aggressiveness

(2014) Allison A. Madigan et al.   AMERICAN JOURNAL OF PATHOLOGY

Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

(2014) Stéphan Hardivillé et al.   Cell Metabolism

O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41

(2014) Stéphanie Olivier-Van Stichelen et al.   FASEB JOURNAL

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

(2014) Daniel Veigel et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Insulin signaling controls the expression of O-GlcNAc transferase and its interaction with lipid microdomains

(2013) Yobana Perez-Cervera et al.   FASEB JOURNAL

Proteomic Analysis of Two Metabolic Proteins with Potential to Translocate to Plasma Membrane Associated with Tumor Metastasis Development and Drug Targets

(2013) Ting Xue et al.   JOURNAL OF PROTEOME RESEARCH

O-GlcNAcylation: A New Cancer Hallmark?

(2013) Yann Fardini et al.   Frontiers in Endocrinology

Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition

(2012) Ludivine Drougat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression

(2012) S Olivier-Van Stichelen et al.   Oncogenesis

The hexosamine biosynthetic pathway and O-GlcNAcylation drive the expression of β-catenin and cell proliferation

(2011) Stéphanie Olivier-Van Stichelen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Suppression of Glutamine:Fructose-6-phosphate amidotransferase-1 inhibits adipogenesis in 3T3-L1 adipocytes

(2011) Tusty-Jiuan Hsieh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy

(2010) Hajime Orita et al.   CANCER BIOLOGY & THERAPY

Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase

(2010) Dolores Di Vizio et al.   CELL CYCLE

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry

(2008) Vanessa Dehennaut et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

(2008) E. Furuta et al.   CANCER RESEARCH

Regulation of theO-Linked β-N-Acetylglucosamine Transferase by Insulin Signaling

(2008) Stephen A. Whelan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of β-catenin in prostate cancer

(2008) Michelangelo Fiorentino et al.   LABORATORY INVESTIGATION

Identification of Structural and FunctionalO-LinkedN-Acetylglucosamine-bearing Proteins inXenopus laevisOocyte

(2008) Vanessa Dehennaut et al.   MOLECULAR & CELLULAR PROTEOMICS

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

(2008) Xiaoyong Yang et al.   NATURE