O-GlcNAc transferase associates with the MCM2–7 complex and its silencing destabilizes MCM–MCM interactions

From structure to mechanism—understanding initiation of DNA replication

(2017) Alberto Riera et al.   GENES & DEVELOPMENT

The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8

(2017) Kelly N. Chuh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation

(2017) Aneika C. Leney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

(2017) Xiaolu Ma et al.   Nature Communications

A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis

(2017) Sung-Kyun Park et al.   Cell Reports

An OGA-Resistant Probe Allows Specific Visualization and Accurate Identification of O-GlcNAc-Modified Proteins in Cells

(2016) Jing Li et al.   ACS Chemical Biology

Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms

(2016) Stefan Burén et al.   CANCER CELL

Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects

(2016) Chris Lanza et al.   CELL CYCLE

OGT restrains the expansion of DNA damage signaling

(2016) Qiang Chen et al.   NUCLEIC ACIDS RESEARCH

Structure of human Cdc45 and implications for CMG helicase function

(2016) Aline C. Simon et al.   Nature Communications

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative phosphoproteomics reveals crosstalk between phosphorylation andO-GlcNAc in the DNA damage response pathway

(2015) Jun Zhong et al.   PROTEOMICS

Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

(2014) Stéphan Hardivillé et al.   Cell Metabolism

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA

(2014) Stefan A. Samel et al.   GENES & DEVELOPMENT

Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

(2014) Philipp Mertins et al.   MOLECULAR & CELLULAR PROTEOMICS

OGA heterozygosity suppresses intestinal tumorigenesis in Apcmin/+ mice

(2014) Y R Yang et al.   Oncogenesis

O-GlcNAcase Expression is Sensitive to Changes in O-GlcNAc Homeostasis

(2014) Zhen Zhang et al.   Frontiers in Endocrinology

O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2

(2013) Fang Ding et al.   AMINO ACIDS

O-GlcNAc Cycling: A Link Between Metabolism and Chronic Disease

(2013) Michelle R. Bond et al.   Annual Review of Nutrition

Phosphorylation of Minichromosome Maintenance Protein 7 (MCM7) by Cyclin/Cyclin-dependent Kinase Affects Its Function in Cell Cycle Regulation

(2013) Qian Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dbf4 and Cdc7 Proteins Promote DNA Replication through Interactions with Distinct Mcm2–7 Protein Subunits

(2013) Matthew D. Ramer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

(2012) Yong Ryoul Yang et al.   AGING CELL

Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition

(2012) Ludivine Drougat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

O-Linked β-N-Acetylglucosaminylation (O-GlcNAcylation) in Primary and Metastatic Colorectal Cancer Clones and Effect ofN-Acetyl-β-d-glucosaminidase Silencing on Cell Phenotype and Transcriptome

(2012) Galit Yehezkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Global Identification and Characterization of BothO-GlcNAcylation and Phosphorylation at the Murine Synapse

(2012) Jonathan C. Trinidad et al.   MOLECULAR & CELLULAR PROTEOMICS

Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells

(2012) Chen-Hua Chuang et al.   NUCLEIC ACIDS RESEARCH

Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression

(2012) S Olivier-Van Stichelen et al.   Oncogenesis

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells 

(2011) Jingjing Zhang et al.   CELL CYCLE

Phosphorylation of MCM3 Protein by Cyclin E/Cyclin-dependent Kinase 2 (Cdk2) Regulates Its Function in Cell Cycle

(2011) Junhui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload

(2011) Marjorie A. Kuipers et al.   JOURNAL OF CELL BIOLOGY

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

(2011) Tracey M Gloster et al.   Nature Chemical Biology

O-GlcNAc Transferase Regulates Mitotic Chromatin Dynamics

(2010) Kaoru Sakabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-Linked β-N-acetylglucosamine (O-GlcNAc) Regulates Stress-induced Heat Shock Protein Expression in a GSK-3β-dependent Manner

(2010) Zahra Kazemi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags

(2010) Jessica E Rexach et al.   Nature Chemical Biology

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis

(2010) Z. Wang et al.   Science Signaling

Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation

(2009) L. I. Francis et al.   GENES & DEVELOPMENT

The Mcm Complex: Unwinding the Mechanism of a Replicative Helicase

(2009) M. L. Bochman et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry

(2009) Li-Chiou Chuang et al.   MOLECULAR CELL

Human CDT1 Associates with CDC7 and Recruits CDC45 to Chromatin during S Phase

(2008) Andrea Ballabeni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Structural and FunctionalO-LinkedN-Acetylglucosamine-bearing Proteins inXenopus laevisOocyte

(2008) Vanessa Dehennaut et al.   MOLECULAR & CELLULAR PROTEOMICS

A Mitotic GlcNAcylation/Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein Vimentin

(2008) Chad Slawson et al.   MOLECULAR BIOLOGY OF THE CELL

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

(2008) Sylvain Courbet et al.   NATURE

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex

(2008) D. I. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA