SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection

(2021) Jia-Tsrong Jan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

(2021) Kris M. White et al.   SCIENCE

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Regulation of the ER Stress Response by the Ion Channel Activity of the Infectious Bronchitis Coronavirus Envelope Protein Modulates Virion Release, Apoptosis, Viral Fitness, and Pathogenesis

(2020) Shumin Li et al.   Frontiers in Microbiology

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Host Calcium Channels and Pumps in Viral Infections

(2020) Xingjuan Chen et al.   Cells

Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19

(2020) Ahmet Kursat Azkur et al.   ALLERGY

Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19

(2020) Huilan Zhang et al.   ANNALS OF INTERNAL MEDICINE

Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

(2020) Ren-Di Jiang et al.   CELL

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2

(2020) Alba Grifoni et al.   Cell Host & Microbe

Characterization and bioactivity of grass carp (Ctenopharyngodon idella) interleukin-21: Inducible production and involvement in inflammatory regulation

(2020) Anying Zhang et al.   FISH & SHELLFISH IMMUNOLOGY

SARS-CoV-2 Vaccines: Status Report

(2020) Fatima Amanat et al.   IMMUNITY

Management of acute ischemic stroke in patients with COVID-19 infection: Report of an international panel

(2020) Adnan I Qureshi et al.   International Journal of Stroke

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The case of Complement activation in COVID-19 multiorgan impact

(2020) Marina Noris et al.   KIDNEY INTERNATIONAL

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

SARS-CoV-2 and viral sepsis: observations and hypotheses

(2020) Hui Li et al.   LANCET

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

News Feature: Avoiding pitfalls in the pursuit of a COVID-19 vaccine

(2020) Lynne Peeples   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remdesivir in covid-19

(2020) Robin E Ferner et al.   BMJ-British Medical Journal

Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19)

(2020) Giuseppe Lippi et al.   ANNALS OF CLINICAL BIOCHEMISTRY

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

Neurological associations of COVID-19

(2020) Mark A Ellul et al.   LANCET NEUROLOGY

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

(2020) Brandi N. Williamson et al.   NATURE

Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy

(2020) Shuo Du et al.   CELL

A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

(2020) Ya-Nan Zhang et al.   CELL RESEARCH

Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation

(2020) Shuaiyao Lu et al.   CELL RESEARCH

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV ‐2 to the PDZ domain of the tight junction‐associated PALS1 protein

(2020) Angelo Toto et al.   PROTEIN SCIENCE

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

(2020) Sourish Ghosh et al.   CELL

Structure-based development of human antibody cocktails against SARS-CoV-2

(2020) Nan Wang et al.   CELL RESEARCH

Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models

(2020) Gan Wang et al.   CELL RESEARCH

SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19

(2020) Tikam Chand Dakal   IMMUNOBIOLOGY

Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation

(2020) Feng-Liang Liu et al.   National Science Review

The Infectious Bronchitis Coronavirus Envelope Protein Alters Golgi pH to Protect Spike Protein and Promote Release of Infectious Virus

(2019) Jason W. Westerbeck et al.   JOURNAL OF VIROLOGY

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Functional characterization of three fish-specific interleukin-23 isoforms as regulators of Th17 signature cytokine expression in grass carp head kidney leukocytes

(2019) Licheng Yin et al.   FISH & SHELLFISH IMMUNOLOGY

Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle

(2019) Yingying Cong et al.   JOURNAL OF VIROLOGY

The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

(2018) Jenny K. Stodola et al.   VIROLOGY

The ω-carboxyl group of 7-ketocholesteryl-9-carboxynonanoate mediates the binding of oxLDL to CD36 receptor and enhances caveolin-1 expression in macrophages

(2017) Jingda Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL forms cation channels

(2016) Bingqing Xia et al.   CELL RESEARCH

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

(2015) Jasper F. W. Chan et al.   CLINICAL MICROBIOLOGY REVIEWS

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

Ion flux in the lung: virus-induced inflammasome activation

(2014) Kathy Triantafilou et al.   TRENDS IN MICROBIOLOGY

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

(2014) Jose L. Nieto-Torres et al.   PLoS Pathogens

Analysis of SARS-CoV E protein ion channel activity by tuning the protein and lipid charge

(2013) Carmina Verdiá-Báguena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

(2009) Konstantin Pervushin et al.   PLoS Pathogens