Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells

(2021) Romina J. Bevacqua et al.   GENES & DEVELOPMENT

Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

(2021) Jason W Millington et al.   eLife

Balancing energy expenditure and storage with growth and biosynthesis during Drosophila development

(2021) Claire M. Gillette et al.   DEVELOPMENTAL BIOLOGY

Control of feeding by Piezo-mediated gut mechanosensation in Drosophila

(2021) Soohong Min et al.   eLife

Response of the microbiome–gut–brain axis in Drosophila to amino acid deficit

(2021) Boram Kim et al.   NATURE

Periphery signals generated by Piezo-mediated stomach stretch and Neuromedin-mediated glucose load regulate the Drosophila brain nutrient sensor

(2021) Yangkyun Oh et al.   NEURON

A cell atlas of the adult Drosophila midgut

(2020) Ruei-Jiun Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown

(2020) Lianna W. Wat et al.   PLOS BIOLOGY

Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

(2020) Esther van Dam et al.   Cell Metabolism

A neural circuit mechanism for mechanosensory feedback control of ingestion

(2020) Dong-Yoon Kim et al.   NATURE

An intestinal zinc sensor regulates food intake and developmental growth

(2020) Siamak Redhai et al.   NATURE

A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

(2020) Aaron M Allen et al.   eLife

Thinking small: zinc‐sensing by the gut epithelium

(2020) Nieves Fernández‐Gallego et al.   ALLERGY

Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation

(2020) Tomotsune Ameku et al.   CURRENT OPINION IN NEUROBIOLOGY

Reclaiming Warburg: using developmental biology to gain insight into human metabolic diseases

(2020) Daniela Drummond-Barbosa et al.   DEVELOPMENT

Ageing, metabolism and the intestine

(2020) Maja C Funk et al.   EMBO REPORTS

Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila

(2020) Sara Mahmoud H. Ahmed et al.   NATURE

Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila

(2020) Lisa Zipper et al.   eLife

How commensal microbes shape the physiology of Drosophila melanogaster

(2020) Theodore Grenier et al.   Current Opinion in Insect Science

Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons

(2020) Ava E. Brent et al.   Cell Metabolism

Identification of Split-GAL4 Drivers and Enhancers That Allow Regional Cell Type Manipulations of the Drosophila melanogaster Intestine

(2020) Ishara S. Ariyapala et al.   GENETICS

Cell fate specification and differentiation in the adult mammalian intestine

(2020) Joep Beumer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor

(2020) Pingping Wang et al.   NEURON

Systemic muscle wasting and coordinated tumour response drive tumourigenesis

(2020) Holly Newton et al.   Nature Communications

Understanding the role of lipids and lipoproteins in development

(2020) Wilhelm Palm et al.   DEVELOPMENT

Identification and characterization of GAL4 drivers that mark distinct cell types and regions in the Drosophila adult gut

(2020) Seung Yeon Lim et al.   JOURNAL OF NEUROGENETICS

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

(2019) Fiona M. Gribble et al.   Nature Reviews Endocrinology

Split-QF System for Fine-Tuned Transgene Expression in Drosophila

(2019) Olena Riabinina et al.   GENETICS

No direct effect of SGLT2 activity on glucagon secretion

(2019) Rune E. Kuhre et al.   DIABETOLOGIA

Perspectives on gene expression regulation techniques in Drosophila

(2019) Rong-Gang Xu et al.   Journal of Genetics and Genomics

Gastrointestinal capacity, gut hormones and appetite change during rat pregnancy and lactation

(2019) Michelle L Johnson et al.   REPRODUCTION

An Interscholastic Network to Generate LexA Enhancer Trap Lines in Drosophila

(2019) Lutz Kockel et al.   G3-Genes Genomes Genetics

Zinc-induced activation of GPR39 regulates glucose homeostasis through glucose-dependent insulinotropic polypeptide secretion from enteroendocrine K-cells

(2019) Brian M. Moran et al.   BIOLOGICAL CHEMISTRY

Metabolite Exchange between Mammalian Organs Quantified in Pigs

(2019) Cholsoon Jang et al.   Cell Metabolism

FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

(2019) Cristal M. Hill et al.   Cell Reports

Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation

(2019) Bruno Hudry et al.   CELL

The Multidimensional Organization of Interorgan Communication Networks

(2019) Ilia A. Droujinine et al.   DEVELOPMENTAL CELL

Regulation of insulin and adipokinetic hormone/glucagon production in flies

(2019) Muhammad Ahmad et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Genetic Identification of Vagal Sensory Neurons That Control Feeding

(2019) Ling Bai et al.   CELL

Sex differences in metabolic regulation and diabetes susceptibility

(2019) Blandine Tramunt et al.   DIABETOLOGIA

Sex and gender analysis improves science and engineering

(2019) Cara Tannenbaum et al.   NATURE

A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila

(2019) Yangkyun Oh et al.   NATURE

Molecular mechanisms and physiological importance of circadian rhythms

(2019) Alina Patke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for delta cell paracrine regulation in pancreatic islets

(2019) Rafael Arrojo e Drigo et al.   Nature Communications

Rethinking Food Reward

(2019) Ivan E. de Araujo et al.   Annual Review of Psychology

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

(2019) Xingting Guo et al.   Cell Reports

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

(2018) Kristofer Davie et al.   CELL

Drosophilaas a model to study obesity and metabolic disease

(2018) Laura Palanker Musselman et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics

(2018) Vincent Croset et al.   eLife

Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain

(2018) Anna N. King et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Discovering human diabetes-risk gene function with genetics and physiological assays

(2018) Heshan Peiris et al.   Nature Communications

Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner

(2018) Tomotsune Ameku et al.   PLOS BIOLOGY

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

(2018) Alessandro Scopelliti et al.   Cell Metabolism

Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood

(2018) Gilles Storelli et al.   DEVELOPMENTAL CELL

Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

(2018) Irene Miguel-Aliaga et al.   GENETICS

Triacylglycerol Metabolism in Drosophila melanogaster

(2018) Christoph Heier et al.   GENETICS

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Regulation of intestinal growth in response to variations in energy supply and demand

(2018) K. N. Nilaweera et al.   Obesity Reviews

Taking Stock of the Drosophila Research Ecosystem

(2017) David Bilder et al.   GENETICS

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

(2017) David P Leader et al.   NUCLEIC ACIDS RESEARCH

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

(2017) Jinghan Sun et al.   Nature Communications

The sex of specific neurons controls female body growth in Drosophila

(2017) Annick Sawala et al.   PLOS BIOLOGY

Taking Stock of the Drosophila Research Ecosystem

(2017) David Bilder et al.   GENETICS

Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints

(2017) Cristal M. Hill et al.   Scientific Reports

Interorgan Communication Pathways in Physiology: Focus onDrosophila

(2016) Ilia A. Droujinine et al.   Annual Review of Genetics

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

(2016) Samantha M. Solon-Biet et al.   Cell Metabolism

UsingDrosophilato discover mechanisms underlying type 2 diabetes

(2016) Ronald W. Alfa et al.   Disease Models & Mechanisms

The interplay between obesity and cancer: a fly view

(2016) Susumu Hirabayashi   Disease Models & Mechanisms

A review of recent evidence relating to sugars, insulin resistance and diabetes

(2016) I. A. Macdonald   EUROPEAN JOURNAL OF NUTRITION

Editing Transgenic DNA Components by Inducible Gene Replacement in Drosophila melanogaster

(2016) Chun-Chieh Lin et al.   GENETICS

The sexual identity of adult intestinal stem cells controls organ size and plasticity

(2016) Bruno Hudry et al.   NATURE

Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor

(2016) R. Delanoue et al.   SCIENCE

Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation

(2016) Takashi Koyama et al.   PLOS BIOLOGY

The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

(2016) William E Barry et al.   eLife

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

(2016) Jennifer C Regan et al.   eLife

Editing Transgenic DNA Components by Inducible Gene Replacement in Drosophila melanogaster

(2016) Chun-Chieh Lin et al.   GENETICS

Suppression of Insulin Production and Secretion by a Decretin Hormone

(2015) Ronald W. Alfa et al.   Cell Metabolism

Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation

(2015) Matthew H. Sieber et al.   CURRENT BIOLOGY

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting

(2015) Alejandra Figueroa-Clarevega et al.   DEVELOPMENTAL CELL

Systemic Organ Wasting Induced by Localized Expression of the Secreted Insulin/IGF Antagonist ImpL2

(2015) Young Kwon et al.   DEVELOPMENTAL CELL

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila

(2015) Monica Dus et al.   NEURON

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism

(2015) Rupali Ugrankar et al.   Nature Communications

The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila

(2015) Julie L. Hentze et al.   Scientific Reports

The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster

(2015) Hiroko Sano et al.   PLoS Genetics

The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size

(2015) Elizabeth J. Rideout et al.   PLoS Genetics

Endocrine remodelling of the adult intestine sustains reproduction in Drosophila

(2015) Tobias Reiff et al.   eLife

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis

(2014) James Cantley   MAMMALIAN GENOME

Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster

(2014) A. C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genetic Strategy to Measure Circulating Drosophila Insulin Reveals Genes Regulating Insulin Production and Secretion

(2014) Sangbin Park et al.   PLoS Genetics

Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling

(2014) Marko Brankatschk et al.   eLife

Transformed Drosophila Cells Evade Diet-Mediated Insulin Resistance through Wingless Signaling

(2013) Susumu Hirabayashi et al.   CELL

CRISPR/Cas9 and Genome Editing in Drosophila

(2013) Andrew R. Bassett et al.   Journal of Genetics and Genomics

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

(2013) Nicolas Buchon et al.   Cell Reports

Physiological and stem cell compartmentalization within the Drosophila midgut

(2013) Alexis Marianes et al.   eLife

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Development of diet-induced insulin resistance in adult Drosophila melanogaster

(2012) Siti Nur Sarah Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Drosophila Cytokine Unpaired 2 Regulates Physiological Homeostasis by Remotely Controlling Insulin Secretion

(2012) Akhila Rajan et al.   CELL

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

FlyAtlas: database of gene expression in the tissues of Drosophila melanogaster

(2012) S. W. Robinson et al.   NUCLEIC ACIDS RESEARCH

High Sugar-Induced Insulin Resistance in Drosophila Relies on the Lipocalin Neural Lazarillo

(2012) Matthieu Y. Pasco et al.   PLoS One

Lipoproteins in Drosophila melanogaster—Assembly, Function, and Influence on Tissue Lipid Composition

(2012) Wilhelm Palm et al.   PLoS Genetics

Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth

(2011) Lucy Erin O'Brien et al.   CELL

Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis

(2011) Paola Cognigni et al.   Cell Metabolism

Coordinating Growth and Maturation — Insights from Drosophila

(2011) Jason M. Tennessen et al.   CURRENT BIOLOGY

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

(2011) L. Palanker Musselman et al.   Disease Models & Mechanisms

Focusing Transgene Expression in Drosophila by Coupling Gal4 With a Novel Split-LexA Expression System

(2011) Chun-Yuan Ting et al.   GENETICS

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

(2011) Rita Sousa-Nunes et al.   NATURE

Taste-independent detection of the caloric content of sugar in Drosophila

(2011) M. Dus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The contribution of the Drosophila model to lipid droplet research

(2011) Ronald P. Kühnlein   PROGRESS IN LIPID RESEARCH

Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm Is Regulated by Notch Signaling

(2011) Sangbin Park et al.   PLoS Genetics

The Q System: A Repressible Binary System for Transgene Expression, Lineage Tracing, and Mosaic Analysis

(2010) Christopher J. Potter et al.   CELL

High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila

(2010) Ryan T. Birse et al.   Cell Metabolism

The Amphimedon queenslandica genome and the evolution of animal complexity

(2010) Mansi Srivastava et al.   NATURE

Glucose increases activity and Ca2+ in insulin-producing cells of adult Drosophila

(2010) Orsolya Kréneisz et al.   NEUROREPORT

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling

(2010) Lutz Kockel et al.   PLoS Genetics

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Citrate transport and metabolism in mammalian cells

(2009) Maria E. Mycielska et al.   BIOESSAYS

Remote Control of Insulin Secretion by Fat Cells in Drosophila

(2009) Charles Géminard et al.   Cell Metabolism

Drosophila ALS Regulates Growth and Metabolism through Functional Interaction with Insulin-Like Peptides

(2008) Nathalie Arquier et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Sex-specific genetic architecture of human disease

(2008) Carole Ober et al.   NATURE REVIEWS GENETICS

Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs

(2008) Susan Broughton et al.   PLoS One

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons

(2008) J. Clements et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postmitotic Specification of Drosophila Insulinergic Neurons from Pioneer Neurons

(2008) Irene Miguel-Aliaga et al.   PLOS BIOLOGY