SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation

Beyond Kinase Activity: ERK5 Nucleo-Cytoplasmic Shuttling as a Novel Target for Anticancer Therapy

(2020) Alessandro Tubita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of ERK5 on the Hallmarks of Cancer

(2019) Barbara Stecca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sumoylation and phosphorylation: hidden and overt links

(2018) Konstantin Tomanov et al.   JOURNAL OF EXPERIMENTAL BOTANY

A kinome-wide high-content siRNA screen identifies MEK5–ERK5 signaling as critical for breast cancer cell EMT and metastasis

(2018) Simona Pavan et al.   ONCOGENE

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

(2018) Angelina V. Vaseva et al.   CANCER CELL

SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase

(2017) Anna M. Knittle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation Promotes Nuclear Import and Stabilization of Polo-like Kinase 1 to Support Its Mitotic Function

(2017) Donghua Wen et al.   Cell Reports

MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism

(2016) Diane M. Pereira et al.   Oncotarget

The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma

(2014) Elisabetta Rovida et al.   GUT

ERK5/BMK1 Is Indispensable for Optimal Colony-Stimulating Factor 1 (CSF-1)-Induced Proliferation in Macrophages in a Src-Dependent Fashion

(2014) E. Rovida et al.   JOURNAL OF IMMUNOLOGY

De-SUMOylation Enzyme of Sentrin/SUMO-Specific Protease 2 Regulates Disturbed Flow–Induced SUMOylation of ERK5 and p53 that Leads to Endothelial Dysfunction and Atherosclerosis

(2013) Kyung-Sun Heo et al.   CIRCULATION RESEARCH

Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Complex

(2013) T. Erazo et al.   MOLECULAR AND CELLULAR BIOLOGY

PIAS1 Is Increased in Human Prostate Cancer and Enhances Proliferation through Inhibition of p21

(2012) Julia Hoefer et al.   AMERICAN JOURNAL OF PATHOLOGY

ERK5 and its role in tumour development: Figure 1

(2012) Pamela A. Lochhead et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Brain Specific Kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment

(2011) Arantza Rodríguez-Asiain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ERK5 signalling in prostate cancer promotes an invasive phenotype

(2011) A K Ramsay et al.   BRITISH JOURNAL OF CANCER

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

(2010) Qingkai Yang et al.   CANCER CELL

Alternative ERK5 regulation by phosphorylation during the cell cycle

(2010) Francisco A. Iñesta-Vaquera et al.   CELLULAR SIGNALLING

The Inotropic Peptide βARKct Improves βAR Responsiveness in Normal and Failing Cardiomyocytes Through G βγ -Mediated L-Type Calcium Current Disinhibition

(2010) Mirko Völkers et al.   CIRCULATION RESEARCH

Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues

(2010) Stergios J. Moschos et al.   HUMAN PATHOLOGY

SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor

(2010) B. Sehat et al.   Science Signaling

ERK5 Activity Is Required for Nerve Growth Factor-induced Neurite Outgrowth and Stabilization of Tyrosine Hydroxylase in PC12 Cells

(2009) Yutaro Obara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of protein SUMOylation in vivo

(2009) Michael H Tatham et al.   Nature Protocols

Expression of Erk5 in Early Stage Breast Cancer and Association with Disease Free Survival Identifies this Kinase as a Potential Therapeutic Target

(2009) Juan Carlos Montero et al.   PLoS One

Extracellular Signal-Regulated Kinase 5 SUMOylation Antagonizes Shear Stress–Induced Antiinflammatory Response and Endothelial Nitric Oxide Synthase Expression in Endothelial Cells

(2008) Chang-Hoon Woo et al.   CIRCULATION RESEARCH

Effects of MEK5/ERK5 Association on Small Ubiquitin-Related Modification of ERK5: Implications for Diabetic Ventricular Dysfunction After Myocardial Infarction

(2008) Tetsuro Shishido et al.   CIRCULATION RESEARCH

DeSUMOylating enzymes-SENPs

(2008) Marcin Drag et al.   IUBMB LIFE

ERK5 differentially regulates PDGF-induced proliferation and migration of hepatic stellate cells

(2007) Elisabetta Rovida et al.   JOURNAL OF HEPATOLOGY