Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Regulatory T Cells and Human Disease

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Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

(2019) James B. Wing et al.   IMMUNITY

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

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Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy

(2019) Mauro Di Pilato et al.   NATURE

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

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CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells

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Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

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Targeting CCR8 induces protective antitumor immunity and enhances vaccine-induced responses in colon cancer

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Tumor Tolerance–Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin

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Understanding the tumor immune microenvironment (TIME) for effective therapy

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Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

(2018) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

(2018) Daniel DiToro et al.   SCIENCE

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Anti-CTLA-4 immunotherapy does not deplete FOXP3+ regulatory T cells (Tregs) in human cancers-Letter

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Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody

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Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

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Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen

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Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

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Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

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Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy

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Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

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Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

(2016) George Plitas et al.   IMMUNITY

Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells

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Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

(2016) Robert L. Ferris et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

(2015) Alison M. Paterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune homeostasis enforced by co-localized effector and regulatory T cells

(2015) Zhiduo Liu et al.   NATURE

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

(2015) Dapeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients

(2015) Emanuela Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Confusing signals: Recent progress in CTLA-4 biology

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Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

(2014) John C Castle et al.   BMC GENOMICS

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

(2014) Christian A. Bauer et al.   JOURNAL OF CLINICAL INVESTIGATION

CD28–CD80 Interactions Control Regulatory T Cell Motility and Immunological Synapse Formation

(2014) Timothy J. Thauland et al.   JOURNAL OF IMMUNOLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

(2014) Desirée Schubert et al.   NATURE MEDICINE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

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Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3

(2013) Aleksandra Kowalczyk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells

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Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells

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Depleting tumor-specific Tregs at a single site eradicates disseminated tumors

(2013) Aurélien Marabelle et al.   JOURNAL OF CLINICAL INVESTIGATION

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

(2013) Yannick Bulliard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

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Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1

(2013) C. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

(2013) S. Malchow et al.   SCIENCE

Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

(2013) M. J. Selby et al.   Cancer Immunology Research

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

(2012) Robert M. Samstein et al.   CELL

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage

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Optimal Population of FoxP3+ T Cells in Tumors Requires an Antigen Priming-Dependent Trafficking Receptor Switch

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Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

T Cell and APC Dynamics In Situ Control the Outcome of Vaccination

(2010) K. M. Khanna et al.   JOURNAL OF IMMUNOLOGY

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells

(2009) W. E. O'Gorman et al.   JOURNAL OF IMMUNOLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

(2009) Graham P. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentiviral Transduction of Mammary Stem Cells for Analysis of Gene Function during Development and Cancer

(2008) Bryan E. Welm et al.   Cell Stem Cell

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology