A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells

Control of regulatory T cell homeostasis

(2020) Maja Buszko et al.   CURRENT OPINION IN IMMUNOLOGY

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells

(2019) Billur Akkaya et al.   NATURE IMMUNOLOGY

CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes

(2019) Moritz Rapp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity

(2019) Antonio P. Baptista et al.   IMMUNITY

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance

(2019) Zinan Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diffusion of cytokines in live lymph node tissue using microfluidic integrated optical imaging

(2018) A.E. Ross et al.   ANALYTICA CHIMICA ACTA

A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System

(2017) Alon Oyler-Yaniv et al.   IMMUNITY

Discovery of stimulation-responsive immune enhancers with CRISPR activation

(2017) Dimitre R. Simeonov et al.   NATURE

Is autoimmunity the Achilles' heel of cancer immunotherapy?

(2017) Carl H June et al.   NATURE MEDICINE

Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D)

(2017) Weizhe Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses

(2016) Susanne Heinzel et al.   NATURE IMMUNOLOGY

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

(2016) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

(2016) Karmel A Allison et al.   eLife

Perfect and Near-Perfect Adaptation in Cell Signaling

(2016) James E. Ferrell   Cell Systems

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

Genetic basis of autoimmunity

(2015) Alexander Marson et al.   JOURNAL OF CLINICAL INVESTIGATION

Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

(2015) H.-S. Lim et al.   JOURNAL OF IMMUNOLOGY

Immune homeostasis enforced by co-localized effector and regulatory T cells

(2015) Zhiduo Liu et al.   NATURE

Statistical analysis of cell migration in 3D using the anisotropic persistent random walk model

(2015) Pei-Hsun Wu et al.   Nature Protocols

T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens

(2015) Guillaume Voisinne et al.   Cell Reports

Three-Dimensional Gradients of Cytokine Signaling between T Cells

(2015) Kevin Thurley et al.   PLoS Computational Biology

Revisiting Thymic Positive Selection and the Mature T Cell Repertoire for Antigen

(2014) Nienke Vrisekoop et al.   IMMUNITY

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

CD28–CD80 Interactions Control Regulatory T Cell Motility and Immunological Synapse Formation

(2014) Timothy J. Thauland et al.   JOURNAL OF IMMUNOLOGY

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

(2014) Desirée Schubert et al.   NATURE MEDICINE

Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

(2014) J. M. Marchingo et al.   SCIENCE

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

(2014) H. S. Kuehn et al.   SCIENCE

T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

(2014) Karen E Tkach et al.   eLife

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

(2013) Noah J. Tubo et al.   CELL

A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

(2013) Jun Huang et al.   IMMUNITY

IL-2 coordinates IL-2–producing and regulatory T cell interplay

(2013) Inês F. Amado et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism

(2013) P. Francois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quorum sensing allows T cells to discriminate between self and nonself

(2013) T. C. Butler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-to-Cell Variability Analysis Dissects the Plasticity of Signaling of Common   Chain Cytokines in T Cells

(2013) J. W. Cotari et al.   Science Signaling

Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes

(2012) Michael Y. Gerner et al.   IMMUNITY

The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude

(2012) M. K. Jenkins et al.   JOURNAL OF IMMUNOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells

(2012) J. N. Mandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

(2012) L. Pace et al.   SCIENCE

T-Cell Tolerance: Central and Peripheral

(2012) Y. Xing et al.   Cold Spring Harbor Perspectives in Biology

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses

(2012) Thomas Höfer et al.   Frontiers in Immunology

Single Cell Analysis of Ligand Binding and Complex Formation of Interleukin-4 Receptor Subunits

(2011) Thomas Weidemann et al.   BIOPHYSICAL JOURNAL

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

(2011) Wei Liao et al.   CURRENT OPINION IN IMMUNOLOGY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

(2010) Ofer Feinerman et al.   Molecular Systems Biology

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

(2010) D. Busse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Attenuated T Cell Responses to a High-Potency Ligand In Vivo

(2010) Emily Corse et al.   PLOS BIOLOGY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY