Mitochondrial pyruvate carrier 1 regulates ferroptosis in drug-tolerant persister head and neck cancer cells via epithelial-mesenchymal transition

DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancer

(2020) Eva Galle et al.   Clinical Epigenetics

Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance

(2020) Milad Ashrafizadeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

xCT inhibitor sulfasalazine depletes paclitaxel‑resistant tumor cells through ferroptosis in uterine serous carcinoma

(2020) Akiko Sugiyama et al.   Oncology Letters

Combined Treatment with JFKD and Gefitinib Overcomes Drug Resistance in Non-Small Cell Lung Cancer

(2020) Xiaoming Huang et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance

(2019) Yuji Takaoka et al.   CANCER SCIENCE

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

MPC1 deletion is associated with poor prognosis and temozolomide resistance in glioblastoma

(2019) Yi Chai et al.   JOURNAL OF NEURO-ONCOLOGY

Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma

(2019) Shogo Okazaki et al.   CANCER SCIENCE

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

(2019) Sean C. Tompkins et al.   Cell Reports

A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism

(2019) Jiujie Cui et al.   ONCOGENE

KDM5 demethylases and their role in cancer cell chemoresistance

(2018) J. Plch et al.   INTERNATIONAL JOURNAL OF CANCER

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms

(2017) Toshimitsu Yamaoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KDM5A promotes proliferation and EMT in ovarian cancer and closely correlates with PTX resistance

(2017) Tongfu Feng et al.   Molecular Medicine Reports

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells

(2017) Xiaoli Li et al.   Oncotarget

Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas

(2016) Yaqing Li et al.   Oncotarget

Balancing Safety and Efficacy of Epidermal Growth Factor Receptor Inhibitors in Patients With Squamous Cell Carcinoma of the Head and Neck

(2015) D. J. Iberri et al.   ONCOLOGIST

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

(2015) Eliezer M. Van Allen et al.   JAMA Oncology

A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth

(2014) John C. Schell et al.   MOLECULAR CELL

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier

(2014) Nathaniel M. Vacanti et al.   MOLECULAR CELL

Drug resistance to targeted therapies: Déjà vu all over again

(2014) Floris H. Groenendijk et al.   Molecular Oncology

The KDM5 family of histone demethylases as targets in oncology drug discovery

(2014) Peter Birk Rasmussen et al.   Epigenomics

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL