Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

(2020) Thaise Boeing et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neutrophils as emerging therapeutic targets

(2020) Tamás Németh et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)

(2020) Catrin Sohrabi et al.   International Journal of Surgery

ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020

(2020) Elliott Lilley et al.   BRITISH JOURNAL OF PHARMACOLOGY

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Neutrophils Disturb Pulmonary Microcirculation in Sepsis-induced Acute Lung Injury

(2019) Inwon Park et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation

(2019) Po-Jen Chen et al.   EBioMedicine

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes

(2019) Seung Jin Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Neutrophil extracellular trap‐microparticle complexes trigger neutrophil recruitment via high‐mobility group protein 1 ( HMGB1 )‐toll‐like receptors( TLR2 )/ TLR4 signalling

(2019) Yongzhi Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease

(2019) Scott H. Twaddell et al.   CHEST

Increased adhesive potential of antiphospholipid syndrome neutrophils mediated by beta‐2 integrin Mac‐1

(2019) Gautam Sule et al.   Arthritis & Rheumatology

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration

(2019) Ina Rohwedder et al.   HAEMATOLOGICA

Resveratrol suppresses neutrophil activation via inhibition of Src family kinases to attenuate lung injury

(2019) Yung-Fong Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

(2018) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ligand-specific binding forces of LFA-1 and Mac-1 in neutrophil adhesion and crawling

(2018) Ning Li et al.   MOLECULAR BIOLOGY OF THE CELL

A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

(2018) Dennis Wolf et al.   Nature Communications

Neutrophils use superoxide to control bacterial infection at a distance

(2018) Quang Tien Phan et al.   PLoS Pathogens

The role of neutrophils in cancer

(2018) Robert Grecian et al.   BRITISH MEDICAL BULLETIN

Calcium-Dependent Src Phosphorylation and Reactive Oxygen Species Generation Are Implicated in the Activation of Human Platelet Induced by Thromboxane A2 Analogs

(2018) Pietro Minuz et al.   Frontiers in Pharmacology

6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury

(2017) Yung-Fong Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mesenchymal stem cells improves survival in LPS-induced acute lung injury acting through inhibition of NETs formation

(2017) Leonardo Pedrazza et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils

(2017) Thornin Ear et al.   Journal of Immunology Research

Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model

(2017) Ahmed Z. El-Hashim et al.   Scientific Reports

Acute blood glucose fluctuation enhances rat aorta endothelial cell apoptosis, oxidative stress and pro-inflammatory cytokine expression in vivo

(2016) Na Wu et al.   Cardiovascular Diabetology

Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension

(2016) Feng Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tyrosine kinase signaling pathways in neutrophils

(2016) Krisztina Futosi et al.   IMMUNOLOGICAL REVIEWS

Resveratrol inhibits renal interstitial fibrosis in diabetic nephropathy by regulating AMPK/NOX4/ROS pathway

(2016) Ting He et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

(2016) Che-Wei Lin et al.   JOURNAL OF NATURAL PRODUCTS

TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection

(2016) S Beceiro et al.   Mucosal Immunology

Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications

(2016) Elise Belaidi et al.   PHARMACOLOGY & THERAPEUTICS

Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα

(2016) Po-Jen Chen et al.   Scientific Reports

Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease

(2016) Alejandra Guillermina Miranda-Díaz et al.   Journal of Diabetes Research

Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious

(2016) Fabiane Sônego et al.   Frontiers in Immunology

The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils

(2015) Hsiang-Ruei Liao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The impact of cationic solid lipid nanoparticles on human neutrophil activation and formation of neutrophil extracellular traps (NETs)

(2015) Tsong-Long Hwang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Src Family Kinases and Syk Are Required for Neutrophil Extracellular Trap Formation in Response to �-Glucan Particles

(2015) Sara Nanì et al.   Journal of Innate Immunity

Sirtinol Inhibits Neutrophil Elastase Activity and Attenuates Lipopolysaccharide-Mediated Acute Lung Injury in Mice

(2015) Yung-Fong Tsai et al.   Scientific Reports

Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium

(2015) Chun-Yu Chen et al.   Scientific Reports

A novel immunomodulatory effect of ugonin U in human neutrophils via stimulation of phospholipase C

(2014) Chun-Yu Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant activities and phenolics of fermented Bletilla formosana with eight plant pathogen fungi

(2014) Jianwei Dong et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

(2014) Miklós Kovács et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transmigration of Neutrophils across Inflamed Endothelium Is Signaled through LFA-1 and Src Family Kinase

(2014) M. R. Sarantos et al.   JOURNAL OF IMMUNOLOGY

Class I Phosphoinositide-3-Kinases and Src Kinases Play a Nonredundant Role in Regulation of Adhesion-Independent and -Dependent Neutrophil Reactive Oxygen Species Generation

(2013) L. Fumagalli et al.   JOURNAL OF IMMUNOLOGY

Multiple Roles for Neutrophils in Atherosclerosis

(2012) Oliver Soehnlein   CIRCULATION RESEARCH

The role of neutrophils in autoimmune diseases

(2012) Tamás Németh et al.   IMMUNOLOGY LETTERS

Src tyrosine kinase inhibition prevents pulmonary ischemia–reperfusion-induced acute lung injury

(2012) Takeshi Oyaizu et al.   INTENSIVE CARE MEDICINE

Antimicrobial Constituents from the Tubers ofBletilla ochracea

(2012) Xinzhou Yang et al.   PLANTA MEDICA

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

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(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation

(2010) Miguel Romero et al.   ATHEROSCLEROSIS

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia

(2009) Xiaohan Hu et al.   BMC NEUROSCIENCE

Regulation of phagocyte migration and recruitment by Src-family kinases

(2008) A. Baruzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES