Review
Agriculture, Multidisciplinary
Beatriz T. Martins, Maria Rosario Bronze, M. Rita Ventura
Summary: Virgin olive oil is the main fat consumed in the Mediterranean basin, and its phenolic compounds are known to have health benefits. The low concentrations and limited availability of commercial standards for these compounds have hindered studies on their biological activity. Chemical synthesis is considered a convenient method for obtaining these compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Nutrition & Dietetics
Andres Jimenez-Sanchez, Antonio Jesus Martinez-Ortega, Pablo Jesus Remon-Ruiz, Ana Pinar-Gutierrez, Jose Luis Pereira-Cunill, Pedro Pablo Garcia-Luna
Summary: This narrative review synthesizes and illustrates the characteristics and clinical applications of extra virgin olive oil (EVOO) and its components in the field of clinical nutrition and dietetics. EVOO has diverse health properties and can be used in diet therapy and as a supplement to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus. However, more research is needed to provide specific recommendations for its therapeutic use in different diseases and populations.
Article
Food Science & Technology
Shuyan Han, Hongmei Hou, Yiren Zhang, Zhongxiang Fang, Yun Li, Le Zhang, Yandan Wang, Shijia Zhang, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang
Summary: Naturally occurring polyphenols in virgin olive oil have significant anti-breast cancer activity by inducing apoptosis, inhibiting cell proliferation, and delaying cell cycle progression.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Nutrition & Dietetics
Andrea del Saz-Lara, Maria-Carmen Lopez de las Hazas, Francesco Visioli, Alberto Davalos
Summary: This article systematically reviews the effects of extra virgin olive oil (EVOO) and its phenolic compounds on the epigenetic landscape. The results show that EVOO and its phenolic compounds can induce epigenetic changes that regulate gene expression and molecular targets involved in various metabolic processes. Oleuropein and hydroxytyrosol, for example, have been shown to have epigenetic effects in cancer and other diseases. Understanding the epigenetic effects of EVOO and its phenolic compounds can contribute to the development of pharma-nutritional strategies.
ADVANCES IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Annalisa Noce, Giulia Marrone, Silvia Urciuoli, Francesca Di Daniele, Manuela Di Lauro, Anna Pietroboni Zaitseva, Nicola Di Daniele, Annalisa Romani
Summary: The Mediterranean diet with extra virgin olive oil appears beneficial for patients with chronic kidney disease, improving renal function, reducing oxidative stress and inflammation, enhancing body composition, with more significant and long-lasting effects observed in those consuming high MPC EVOO content.
Article
Microbiology
Andrea Celeste Arismendi Sosa, Maria Laura Mariani, Alba Edith Vega, Alicia Beatriz Penissi
Summary: This study evaluated the antibacterial effect of extra virgin olive oil (EVOO), hydroxytyrosol (HT), and oleuropein (Olp) against Helicobacter pylori in vitro, and examined the impact of oral administration of EVOO on the gastric mucosa of H. pylori-infected mice. The results demonstrated that EVOO exhibited antibacterial activity against H. pylori and reduced gastric mucosal damage in infected mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marisa Di Pietro, Simone Filardo, Roberto Mattioli, Giuseppina Bozzuto, Agnese Molinari, Luciana Mosca, Rosa Sessa
Summary: Polyphenolic extract of extra virgin olive oil (EVOO) has antibacterial activity against Chlamydia trachomatis, inhibiting its ability to infect host cells. Further studies are needed to explore its clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Maite Garcia-Guasch, Mireia Medrano, Irmgard Costa, Elena Vela, Marta Grau, Eduard Escrich, Raquel Moral
Summary: The study aimed to investigate the effects of high-fat diets on breast tumors. The results showed that a diet high in extra-virgin olive oil (EVOO) can reduce tumor aggressiveness and proliferation compared to a diet high in seed oil. Additionally, in vitro experiments confirmed the role of minor compounds in EVOO on tumor pathogenesis.
Article
Biochemistry & Molecular Biology
Martina Bartolomei, Carlotta Bollati, Maria Bellumori, Lorenzo Cecchi, Ivan Cruz-Chamorro, Guillermo Santos-Sanchez, Giulia Ranaldi, Simonetta Ferruzza, Yula Sambuy, Anna Arnoldi, Nadia Mulinacci, Carmen Lammi
Summary: This study provides a comprehensive characterization of the antioxidant properties of phenolic extract (BUO) obtained from extra virgin olive oil, cultivated in Tuscany, Italy. The findings show that BUO extract can reduce harmful substances produced in cells after oxidative stress and demonstrate selective trans-epithelial transport of some phenolic components in differentiated Caco-2 cells, a mature enterocyte model.
Article
Biochemistry & Molecular Biology
Anallely Lopez-Yerena, Antonia Ninot, Nuria Jimenez-Ruiz, Julian Lozano-Castellon, Maria Perez, Elvira Escribano-Ferrer, Agusti Romero-Aroca, Rosa M. Lamuela-Raventos, Anna Vallverdu-Queralt
Summary: The study focused on the ancient 'Corbella' olive variety from Catalonia and found that harvesting olives earlier resulted in a higher content of secoiridoids in the oil. The best processing conditions for high-quality EVOO were determined to be malaxation at 37 degrees Celsius for 30 minutes.
Review
Biochemistry & Molecular Biology
Maria Rita Emma, Giuseppa Augello, Vita Di Stefano, Antonina Azzolina, Lydia Giannitrapani, Giuseppe Montalto, Melchiorre Cervello, Antonella Cusimano
Summary: The Mediterranean diet is rich in antioxidants and anti-inflammatory nutrients, with extra-virgin olive oil playing a key role due to its phenolic compounds and secoiridoids. These compounds have been shown to have antioxidant, anti-inflammatory, and anti-proliferative properties, which contribute to their anti-cancer activity. The review summarizes the pharmacological properties, molecular targets, and action mechanisms of secoiridoids, with a focus on their potential use in cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Marisa Di Pietro, Simone Filardo, Roberto Mattioli, Antonio Francioso, Giammarco Raponi, Luciana Mosca, Rosa Sessa
Summary: This study evaluated the antimicrobial activity of green extra virgin olive oil-based formulations in NaDESs, showing promising results against drug-resistant bacterial strains and Candida spp.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Gabriele Rocchetti, Maria Luisa Callegari, Alice Senizza, Gianluca Giuberti, Jessica Ruzzolini, Annalisa Romani, Silvia Urciuoli, Chiara Nediani, Luigi Lucini
Summary: The modulation of gut microbiota by polyphenols from olives and derived products is of increasing interest. In this study, phenolic leaf extracts (PLE) were in vitro fermented to evaluate changes in phenolic profiles and their impact on microbiota. The fermentation of PLE decreased oleuropein content and increased hydroxytyrosol and other phenolic metabolites. A significant increase in hydroxytyrosol was also observed in fermented extra-virgin olive oil (EVOO). The fermentation of PLE also significantly changed the amino acids and fatty acids profile of the faeces. Metagenomic sequencing revealed that Coriobacteriaceae at the family level and Collinsella at the genus level were the most affected by PLE fermentation.
Article
Biochemistry & Molecular Biology
Julian Lozano-Castellon, Anallely Lopez-Yerena, Alexandra Olmo-Cunillera, Olga Jauregui, Maria Perez, Rosa Ma Lamuela-Raventos, Anna Vallverdu-Queralt
Summary: Extra virgin olive oil (EVOO) is rich in nutritional and antioxidant compounds compared to other vegetable oils, making it an important component of the Mediterranean diet. This study developed a simple UHPLC-ESI-MS/MS method for quantifying secoiridoids in EVOO, overcoming challenges posed by their complex transformations during production and analysis. Validation of the method according to AOAC guidelines showed satisfactory results in terms of matrix effect and recoveries.
Article
Biochemistry & Molecular Biology
Maria Luisa Castejon, Tatiana Montoya, Juan Ortega-Vidal, Joaquin Altarejos, Catalina Alarcon-de-la-Lastra
Summary: The study evaluated the immunomodulatory and anti-inflammatory effects of Ligstroside aglycon (LA) on murine peritoneal macrophages and identified the potential signaling pathways involved. LA showed significant antioxidant and anti-inflammatory effects by reducing oxidative stress markers such as NO production and protein expression. LA was also able to modulate pro-inflammatory cytokine levels and inhibit the activation of certain signaling pathways. The study suggests that LA has potential as a natural agent for the treatment of immune-inflammatory diseases.
Article
Immunology
Debdut Naskar, Fei Teng, Krysta M. Felix, C. Pierce Bradley, Hsin-Jung Joyce Wu
JOURNAL OF IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Payal Gupta, Sreetama Choudhury, Sayan Ghosh, Sudeshna Mukherjee, Olivia Chowdhury, Arindam Sain, Sreya Chattopadhyay
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Review
Immunology
Suborno Jati, Tresa Rani Sarraf, Debdut Naskar, Malini Sen
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Cell Biology
Sayan Ghosh, Sreetama Choudhury, Olivia Chowdhury, Sudeshna Mukherjee, Ankur Das, Arindam Sain, Payal Gupta, Arghya Adhikary, Sreya Chattopadhyay
CELLULAR SIGNALLING
(2020)
Article
Biochemistry & Molecular Biology
Thirukumaran Kandasamy, Babu Sudhamalla, Debdut Naskar
Summary: This study presents a novel method for designing RNA aptamers against the DNA binding domain of the glucocorticoid receptor alpha (GR alpha). Through screening and evaluation, Apt-2, Apt-5, Apt-6, and Apt-15 were found to be the most suitable aptamers.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Arindam Sain, Thirukumaran Kandasamy, Debdut Naskar
Summary: The study identified apigenin, luteolin, pinoresinol, oleuropein, and oleuropein aglycone as promising phenolic compounds from Olea europaea with strong binding affinity to PI3K/Akt/mTOR axis. Among them, apigenin, luteolin, and pinoresinol were selected based on their drug likeness and stability in binding to target proteins through molecular dynamics simulations. These compounds have the potential to be non-toxic alternatives to synthetic chemical inhibitors in CRC treatment, especially pinoresinol as a dual PI3K/mTOR inhibitor. However, further in vitro and in vivo studies are necessary to confirm their efficacy.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Arindam Sain, Thirukumaran Kandasamy, Debdut Naskar
Summary: Colorectal cancer, especially metastatic form, is a major cause of cancer morbidity worldwide. In this study, the interaction between dietary lignans from flaxseed and sesame seeds and the autophagy pathway was investigated using computational simulations. Three dietary lignans were identified as potential inhibitors/modulators of the autophagy pathway.
MOLECULAR DIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Arindam Sain, Dipshikha Khamrai, Thirukumaran Kandasamy, Debdut Naskar
Summary: The study reveals that PTP1B is highly expressed and genetically altered in obesity-related colon cancer (CC), and its inhibition shows a potential therapeutic target. Sweet potato compounds, such as pelargonidin and luteolin, interact with PTP1B and may have protective effects against CC. This research provides new insights into the treatment of obesity-linked CC.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2022)
Article
Microbiology
C. Pierce Bradley, Fei Teng, Krysta M. Felix, Teruyuki Sano, Debdut Naskar, Katharine E. Block, Haochu Huang, Kenneth S. Knox, Dan R. Littman, Hsin-Jung Joyce Wu
CELL HOST & MICROBE
(2017)
Article
Rheumatology
Fei Teng, Krysta M. Felix, C. Pierce Bradley, Debdut Naskar, Heqing Ma, Walid A. Raslan, Hsin-Jung Joyce Wu
ARTHRITIS RESEARCH & THERAPY
(2017)