CRISPR activation of long non-coding RNA DANCR promotes bone regeneration

Downregulation of microRNA-203a suppresses IL-1β-induced inflammation and cartilage degradation in human chondrocytes through Smad3 signaling

(2020) Yongbo An et al.   BIOSCIENCE REPORTS

The promise and challenge of therapeutic genome editing

(2020) Jennifer A. Doudna   NATURE

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery

(2020) Lekha Nair et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CRISPR-Based Synthetic Transcription Factors In Vivo: The Future of Therapeutic Cellular Programming

(2020) Matthew Pandelakis et al.   Cell Systems

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

(2020) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

CRISPR interference-mediated noggin knockdown promotes BMP2-induced osteogenesis and calvarial bone healing

(2020) Mu-Nung Hsu et al.   BIOMATERIALS

Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation

(2020) Eric Schoger et al.   Stem Cell Research

A gene therapy for inherited blindness using dCas9-VPR–mediated transcriptional activation

(2020) Sybille Böhm et al.   Science Advances

DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression

(2019) Ziyue Chen et al.   MOLECULAR THERAPY

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CRISPRai for simultaneous gene activation and inhibition to promote stem cell chondrogenesis and calvarial bone regeneration

(2019) Vu Anh Truong et al.   NUCLEIC ACIDS RESEARCH

A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene

(2019) Dwi U. Kemaladewi et al.   NATURE

CRISPR technologies for stem cell engineering and regenerative medicine

(2019) Mu-Nung Hsu et al.   BIOTECHNOLOGY ADVANCES

Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer

(2019) Liye Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coactivation of Endogenous Wnt10b and Foxc2 by CRISPR Activation Enhances BMSC Osteogenesis and Promotes Calvarial Bone Regeneration

(2019) Mu-Nung Hsu et al.   MOLECULAR THERAPY

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance

(2018) Assaf C. Bester et al.   CELL

Towards a complete map of the human long non-coding RNA transcriptome

(2018) Barbara Uszczynska-Ratajczak et al.   NATURE REVIEWS GENETICS

Evidences for a New Role of miR-214 in Chondrogenesis

(2018) Vânia Palma Roberto et al.   Scientific Reports

Delivery of an Artificial Transcription Regulator dCas9-VPR by Extracellular Vesicles for Therapeutic Gene Activation

(2018) Duško Lainšček et al.   ACS Synthetic Biology

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

(2017) Julia Joung et al.   NATURE

SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells

(2017) Laurie M. G. de Kroon et al.   Scientific Reports

Healing of osteoporotic bone defects by baculovirus-engineered bone marrow-derived MSCs expressing MicroRNA sponges

(2016) Kuei-Chang Li et al.   BIOMATERIALS

Graphene oxide as a chemosensitizer: Diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects

(2015) Guan-Yu Chen et al.   BIOMATERIALS

Healing of massive segmental femoral bone defects in minipigs by allogenic ASCs engineered with FLPo/Frt-based baculovirus vectors

(2015) Chin-Yu Lin et al.   BIOMATERIALS

The Role of miRNAs in Cartilage Homeostasis

(2015) Yong Li et al.   CURRENT GENOMICS

Long noncoding RNADANCRincreases stemness features of hepatocellular carcinoma by derepression ofCTNNB1

(2015) Sheng-xian Yuan et al.   HEPATOLOGY

Highly efficient Cas9-mediated transcriptional programming

(2015) Alejandro Chavez et al.   NATURE METHODS

Role of miRNAs in bone and their potential as therapeutic targets

(2014) Kyoung Min Kim et al.   CURRENT OPINION IN PHARMACOLOGY

Efficient gene delivery into cell lines and stem cells using baculovirus

(2014) Li-Yu Sung et al.   Nature Protocols

The use of ASCs engineered to express BMP2 or TGF-β3 within scaffold constructs to promote calvarial bone repair

(2013) Chin-Yu Lin et al.   BIOMATERIALS

Baculovirus-transduced, VEGF-expressing adipose-derived stem cell sheet for the treatment of myocardium infarction

(2013) Tsung-Szu Yeh et al.   BIOMATERIALS

Recent progresses in gene delivery-based bone tissue engineering

(2013) Chia-Hsin Lu et al.   BIOTECHNOLOGY ADVANCES

MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix

(2013) Kaikai Shi et al.   BONE

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Regenerating Cartilages by Engineered ASCs: Prolonged TGF-β3/BMP-6 Expression Improved Articular Cartilage Formation and Restored Zonal Structure

(2013) Chia-Hsin Lu et al.   MOLECULAR THERAPY

Enhanced and prolonged baculovirus-mediated expression by incorporating recombinase system and in cis elements: a comparative study

(2013) Li-Yu Sung et al.   NUCLEIC ACIDS RESEARCH

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis

(2012) Carol G. Chen et al.   ARTHRITIS AND RHEUMATISM

miR-214 targets ATF4 to inhibit bone formation

(2012) Xiaogang Wang et al.   NATURE MEDICINE

Structural architecture of the human long non-coding RNA, steroid receptor RNA activator

(2012) Irina V. Novikova et al.   NUCLEIC ACIDS RESEARCH

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part I: Recapitulation of Native Tissue Healing and Variables for the Design of Delivery Systems

(2012) Vítor E. Santo et al.   TISSUE ENGINEERING PART B-REVIEWS

Cranial bone defects: current and future strategies

(2010) Caroline Szpalski et al.   Neurosurgical Focus