SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells

Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

(2016) Laurie M. G. de Kroon et al.   PLoS One

BMP–Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse

(2015) Joohyun Lim et al.   DEVELOPMENTAL BIOLOGY

An educational review of cartilage repair: precepts & practice – myths & misconceptions – progress & prospects

(2015) E.B. Hunziker et al.   OSTEOARTHRITIS AND CARTILAGE

SMAD4 mutations causing Myhre syndrome result in disorganization of extracellular matrix improved by losartan

(2014) Pasquale Piccolo et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Cartilage Repair With Autologous Bone Marrow Mesenchymal Stem Cell Transplantation

(2014) Shinya Yamasaki et al.   Cartilage

A Restricted Spectrum of Mutations in the SMAD4 Tumor-Suppressor Gene Underlies Myhre Syndrome

(2012) Viviana Caputo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations of SMAD4 account for both LAPS and Myhre syndromes

(2012) Noralane M. Lindor et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis

(2012) Carol G. Chen et al.   ARTHRITIS AND RHEUMATISM

Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds

(2012) J.-D. Benazet et al.   DEVELOPMENT

Proliferation as a Requirement for In Vitro Chondrogenesis of Human Mesenchymal Stem Cells

(2012) Verena Dexheimer et al.   STEM CELLS AND DEVELOPMENT

Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

(2011) Ingrid M B H van de Laar et al.   JOURNAL OF MEDICAL GENETICS

Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome

(2011) Carine Le Goff et al.   NATURE GENETICS

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor β-activated kinase 1/activating transcription factor 2 signaling: A potential clinical implication for osteoarthritis

(2010) Tian-Fang Li et al.   ARTHRITIS AND RHEUMATISM

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering

(2010) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor β Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

(2009) Katharine H. Wrighton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad3 Protein Levels Are Modulated by Ras Activity and during the Cell Cycle to Dictate Transforming Growth Factor-β Responses

(2009) Amanda C. Daly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Phospho-control of TGF-β superfamily signaling

(2008) Katharine H Wrighton et al.   CELL RESEARCH

Smad3 activates the Sox9-dependent transcription on chromatin

(2008) Takayuki Furumatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY