The xenobiotic receptors PXR and CAR in liver physiology, an update

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI

(2020) Xiaowen Yu et al.   Science Translational Medicine

Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)

(2020) Xinran Cai et al.   Acta Pharmaceutica Sinica B

Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock Induced Liver Injury

(2019) Yang Xie et al.   HEPATOLOGY

Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis

(2019) Kouichi Yoshinari   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice

(2019) Andrew J Lickteig et al.   TOXICOLOGICAL SCIENCES

Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

(2019) Céline Lukowicz et al.   Scientific Reports

Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver

(2018) Fatemeh Hassani-Nezhad-Gashti et al.   BIOCHEMICAL PHARMACOLOGY

TCPOBOP-induced hepatomegaly & hepatocyte proliferation is attenuated by combined disruption of MET & EGFR signaling

(2018) Bharat Bhushan et al.   HEPATOLOGY

Role of the Pregnane X Receptor in Binge Ethanol-Induced Steatosis and Hepatotoxicity

(2018) Sora Choi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver

(2018) Takeshi Hori et al.   MOLECULAR CANCER RESEARCH

Activation of Constitutive Androstane Receptor Ameliorates Renal Ischemia-Reperfusion–Induced Kidney and Liver Injury

(2018) You-Jin Choi et al.   MOLECULAR PHARMACOLOGY

Role of YAP Activation in Nuclear Receptor CAR-Mediated Proliferation of Mouse Hepatocytes

(2018) Taiki Abe et al.   TOXICOLOGICAL SCIENCES

Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes

(2018) Corinne Haines et al.   TOXICOLOGY

Pregnane X Receptor Regulates Liver Size and Liver Cell Fate via Yes-associated Protein Activation

(2018) Yiming Jiang et al.   HEPATOLOGY

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice

(2017) Sora Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

(2017) Giovanni Targher et al.   Nature Reviews Nephrology

Constitutive androstane receptor activation evokes the expression of glycolytic genes

(2016) Andrei A. Yarushkin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss

(2016) Christoph Tschuor et al.   JOURNAL OF HEPATOLOGY

Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver

(2016) Andrew J. Lickteig et al.   TOXICOLOGICAL SCIENCES

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way

(2016) Alice Marmugi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation

(2016) Valerie Soldatow et al.   TOXICOLOGY IN VITRO

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

(2016) Petr Pavek   Frontiers in Pharmacology

CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α

(2015) Jie Gao et al.   MOLECULAR ENDOCRINOLOGY

Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver

(2015) Yuliya A. Kazantseva et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis

(2015) Saki Gotoh et al.   Scientific Reports

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms

(2014) Andreas Bitter et al.   ARCHIVES OF TOXICOLOGY

Acute kidney injury—epidemiology, outcomes and economics

(2014) Oleksa Rewa et al.   Nature Reviews Nephrology

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

(2013) J. He et al.   DIABETES

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond

(2013) Xiaojuan Chai et al.   Expert Opinion on Drug Metabolism & Toxicology

Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice

(2013) Krisstonia Spruiell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy

(2013) Feng Li et al.   NATURE MEDICINE

Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression

(2013) Ryota Shizu et al.   TOXICOLOGY LETTERS

Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes

(2012) Kirsty J. McLean et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Constitutive androstane receptor activation by 2,4,6-triphenyldioxane-1,3 suppresses the expression of the gluconeogenic genes

(2012) Ekaterina M. Kachaylo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of CAR and PXR in xenobiotic sensing and metabolism

(2012) Yue-Ming Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

(2012) Jie Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Rifampin Enhances the Glucose-Lowering Effect of Metformin and Increases OCT1 mRNA Levels in Healthy Participants

(2011) S K Cho et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Nuclear Receptors CAR and PXR; therapeutic targets for cholestatic liver disease

(2011) Satoru Kakizaki   Frontiers in Bioscience-Landmark

PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts

(2011) Jinhan He et al.   GASTROENTEROLOGY

Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice

(2011) Marta A. Kowalik et al.   HEPATOLOGY

Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice

(2011) Jianmin Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism

(2011) Tenghui Chen et al.   JOURNAL OF HEPATOLOGY

The nuclear receptor CAR modulates alcohol-induced liver injury

(2011) Xiaosong Chen et al.   LABORATORY INVESTIGATION

Pregnane X Receptor PXR Activates theGADD45β Gene, Eliciting the p38 MAPK Signal and Cell Migration

(2010) Susumu Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Functional Cross-Talk between Liver X Receptor-  and Constitutive Androstane Receptor Links Lipogenesis and Xenobiotic Responses

(2010) Y. Zhai et al.   MOLECULAR PHARMACOLOGY

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

(2009) Shingo Mutoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

(2009) B. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia

(2008) William E. Blanco-Bose et al.   HEPATOLOGY

Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

(2008) A. Roth et al.   MOLECULAR PHARMACOLOGY

Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes

(2008) Adrian Roth et al.   Pharmacogenetics and Genomics

Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis

(2007) S Teng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY