Circadian control of brown adipose tissue

Brown adipose tissue is associated with cardiometabolic health

(2021) Tobias Becher et al.   NATURE MEDICINE

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

(2021) Christian Schlein et al.   Cell Reports

A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function

(2021) Jan Kroon et al.   Molecular Metabolism

Twice as High Diet-Induced Thermogenesis After Breakfast vs Dinner On High-Calorie as Well as Low-Calorie Meals

(2020) Juliane Richter et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment

(2020) Pojchong Chotiyarnwong et al.   Nature Reviews Endocrinology

Time‐Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

(2020) Lisa S. Chow et al.   Obesity

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

(2020) Denis P. Blondin et al.   Cell Metabolism

Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity

(2020) Dylan A. Lowe et al.   JAMA Internal Medicine

Melatonin Multiple Effects on Brown Adipose Tissue Molecular Machinery

(2019) Caroline Aparecida Pereira de Souza et al.   JOURNAL OF PINEAL RESEARCH

Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions

(2019) Joshua R. Beytebiere et al.   GENES & DEVELOPMENT

Melatonin Increases Brown Adipose Tissue Volume and Activity in Melatonin Deficient Patients: a Proof-of-Concept Study

(2019) Bruno Halpern et al.   DIABETES

Adipose tissue browning in mice and humans

(2019) Carsten T Herz et al.   JOURNAL OF ENDOCRINOLOGY

Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?

(2019) Ineke H.N. Luijten et al.   MOLECULAR ASPECTS OF MEDICINE

Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold

(2019) Marine Adlanmerini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

(2019) Michael J. Wilkinson et al.   Cell Metabolism

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14

(2018) Dorothy E. Vatner et al.   AGING CELL

Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

(2018) Mueez U Din et al.   Cell Metabolism

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

(2018) Elizabeth F. Sutton et al.   Cell Metabolism

Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen

(2018) Lin Chang et al.   CIRCULATION

β-Adrenergic receptors control brown adipose UCP-1 tone and cold response without affecting its circadian rhythmicity

(2018) Maria Razzoli et al.   FASEB JOURNAL

Short photoperiod reverses obesity in Siberian hamsters via sympathetically induced lipolysis and Browning in adipose tissue

(2018) Vitaly Ryu et al.   PHYSIOLOGY & BEHAVIOR

A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

(2018) Rosa van den Berg et al.   Cell Reports

Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats

(2018) Daniella Buonfiglio et al.   Frontiers in Endocrinology

Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

(2018) Amandine Chaix et al.   Cell Metabolism

Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice

(2017) Leidyanne Ferreira Gonçalves et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Brown adipose tissue does not seem to mediate metabolic adaptation to overfeeding in men

(2017) Courtney M. Peterson et al.   Obesity

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

(2017) Alexander Bartelt et al.   Nature Communications

Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation

(2016) José K van den Heuvel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans

(2016) Paul Lee et al.   Cell Metabolism

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

(2016) Lynne E. Ramage et al.   Cell Metabolism

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

(2016) Geerte Hoeke et al.   CIRCULATION RESEARCH

Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice

(2016) Justin Darcy et al.   ENDOCRINOLOGY

Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans

(2016) M Hibi et al.   INTERNATIONAL JOURNAL OF OBESITY

Seasonal influence on stimulated BAT activity in prospective trials: a retrospective analysis of BAT visualized on 18F-FDG PET-CTs and 123I-mIBG SPECT-CTs

(2016) Lonneke Bahler et al.   JOURNAL OF APPLIED PHYSIOLOGY

Circadian misalignment increases cardiovascular disease risk factors in humans

(2016) Christopher J. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue

(2015) Patrick Lau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genetic and functional characterization of clonally derived adult human brown adipocytes

(2015) Kosaku Shinoda et al.   NATURE MEDICINE

The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis

(2015) Christopher J. Morris et al.   Obesity

Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity

(2015) Sander Kooijman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discrete functions of nuclear receptor Rev-erb  couple metabolism to the clock

(2015) Y. Zhang et al.   SCIENCE

Neuronal Control of Brown Fat Activity

(2015) Sander Kooijman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

Acute dim light at night increases body mass, alters metabolism, and shifts core body temperature circadian rhythms

(2014) Jeremy C. Borniger et al.   CHRONOBIOLOGY INTERNATIONAL

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

Alterations in diurnal rhythmicity in patients treated for nonfunctioning pituitary macroadenoma: a controlled study and literature review

(2014) S D Joustra et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Direct activating effects of adrenocorticotropic hormone (ACTH) on brown adipose tissue are attenuated by corticosterone

(2014) Johanna C. van den Beukel et al.   FASEB JOURNAL

Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial

(2014) C Bandín et al.   INTERNATIONAL JOURNAL OF OBESITY

Determinants of Altered Sleep-Wake Rhythmicity in Patients Treated for Nonfunctioning Pituitary Macroadenomas

(2014) S. D. Joustra et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

(2014) P. Padmini S. J. Khedoe et al.   JOURNAL OF LIPID RESEARCH

Supraclavicular Skin Temperature as a Measure of 18F-FDG Uptake by BAT in Human Subjects

(2014) Mariëtte R. Boon et al.   PLoS One

Consuming More of Daily Caloric Intake at Dinner Predisposes to Obesity. A 6-Year Population-Based Prospective Cohort Study

(2014) Simona Bo et al.   PLoS One

Mistimed sleep disrupts circadian regulation of the human transcriptome

(2014) Simon N. Archer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Protein, CHRONO, Functions as a Core Component of the Mammalian Circadian Clock

(2014) Akihiro Goriki et al.   PLOS BIOLOGY

Brown adipose tissue activity after a high-calorie meal in humans

(2013) Maarten J Vosselman et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle

(2013) Kenneth P. Wright et al.   CURRENT BIOLOGY

cis -Regulatory Requirements for Tissue-Specific Programs of the Circadian Clock

(2013) Antonio C.A. Meireles-Filho et al.   CURRENT BIOLOGY

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

(2013) Zachary Gerhart-Hines et al.   NATURE

The Biological Clock is Regulated by Adrenergic Signaling in Brown Fat but is Dispensable for Cold-Induced Thermogenesis

(2013) Siming Li et al.   PLoS One

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Role of the circadian clock gene Per2 in adaptation to cold temperature

(2013) Sylvie Chappuis et al.   Molecular Metabolism

Biological aging alters circadian mechanisms in murine adipose tissue depots

(2012) Gregory M. Sutton et al.   AGE

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Appetite-regulating hormones from the upper gut: disrupted control of xenin and ghrelin in night workers

(2012) Daniela Schiavo-Cardozo et al.   CLINICAL ENDOCRINOLOGY

Timed high-fat diet resets circadian metabolism and prevents obesity

(2012) Hadas Sherman et al.   FASEB JOURNAL

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

(2012) Laura A. Solt et al.   NATURE

Obesity in mice with adipocyte-specific deletion of clock component Arntl

(2012) Georgios K Paschos et al.   NATURE MEDICINE

Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks

(2012) Urs Albrecht   NEURON

A Diurnal Rhythm in Glucose Uptake in Brown Adipose Tissue Revealed by In Vivo PET-FDG Imaging

(2012) Daan R. van der Veen et al.   Obesity

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

(2011) Katja A. Lamia et al.   NATURE

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans

(2010) Paul Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Brown Fat and the Myth of Diet-Induced Thermogenesis

(2010) Leslie P. Kozak   Cell Metabolism

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation

(2010) Saurabh Sahar et al.   PLoS One

Brown Adipose Tissue and Seasonal Variation in Humans

(2009) I. T.H. Au-Yong et al.   DIABETES

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

(2009) Nancy Nader et al.   FASEB JOURNAL

CK2α phosphorylates BMAL1 to regulate the mammalian clock

(2009) Teruya Tamaru et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Incidence of metabolic syndrome among night-shift healthcare workers

(2009) A Pietroiusti et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA