Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

Human brown adipose tissue: Classical brown rather than brite/beige?

(2020) Barbara Cannon et al.   EXPERIMENTAL PHYSIOLOGY

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

(2020) Alana E. O’Mara et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse Thermoregulation: Introducing the Concept of the Thermoneutral Point

(2020) Vojtěch Škop et al.   Cell Reports

ChREBP-β regulates thermogenesis in brown adipose tissue

(2020) Chunchun Wei et al.   JOURNAL OF ENDOCRINOLOGY

The answer to the question “What is the best housing temperature to translate mouse experiments to humans?” is: Thermoneutrality

(2019) Alexander W. Fischer et al.   Molecular Metabolism

Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK

(2019) Angelina S Gross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold

(2019) Marine Adlanmerini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brown adipose cross talk in tissue plasticity and human metabolism

(2019) Camilla Scheele et al.   ENDOCRINE REVIEWS

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy

(2019) Maximilian Schütter et al.   CELL

Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity

(2019) Kong Y. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

(2018) Joan Sanchez-Gurmaches et al.   Cell Metabolism

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

(2018) Markus Heine et al.   Cell Metabolism

Adapted MS/MSALL Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species

(2018) Fei Gao et al.   LIPIDS

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

(2018) Alexander Bartelt et al.   NATURE MEDICINE

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

(2018) Xiaodan Lu et al.   Science Signaling

Mechanisms by Which Dietary Fatty Acids Regulate Mitochondrial Structure-Function in Health and Disease

(2018) E Madison Sullivan et al.   Advances in Nutrition

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

(2018) Xiaodan Lu et al.   Science Signaling

Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study

(2018) Alexander W. Fischer et al.   Molecular Metabolism

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

(2018) Alexander W. Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

(2018) Yongguo Li et al.   CELL

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

Warming the mouse to model human diseases

(2017) Kirthana Ganeshan et al.   Nature Reviews Endocrinology

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

(2017) Archana Vijayakumar et al.   Cell Reports

Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

(2017) Tara Jois et al.   Molecular Metabolism

Cardiolipin content, linoleic acid composition, and tafazzin expression in response to skeletal muscle overload and unload stimuli

(2017) Val A. Fajardo et al.   Scientific Reports

Implications of thermogenic adipose tissues for metabolic health

(2016) Christian Schlein et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

(2015) Paul Hsu et al.   Autophagy

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells

(2015) Justyna Janikiewicz et al.   JOURNAL OF LIPID RESEARCH

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

(2014) Emilio P. Mottillo et al.   JOURNAL OF LIPID RESEARCH

Application and interpretation of current autophagy inhibitors and activators

(2013) Ya-ping Yang et al.   ACTA PHARMACOLOGICA SINICA

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

(2013) Leah Eissing et al.   Nature Communications

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Update on lipids and mitochondrial function

(2012) William C. Stanley et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The holy grail of metabolic disease

(2012) Alexander Bartelt et al.   CURRENT OPINION IN LIPIDOLOGY

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Persistent pulmonary hypertension results in reduced tetralinoleoyl-cardiolipin and mitochondrial complex II + III during the development of right ventricular hypertrophy in the neonatal pig heart

(2011) Harjot K. Saini-Chohan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

For the last time, it is GFP-Atg8, not Atg8-GFP (and the same goes for LC3)

(2011) Daniel J Klionsky   Autophagy

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway

(2010) Koji Komiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

(2009) Maria Cristina Zingaretti et al.   FASEB JOURNAL

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure

(2008) Harjot K. Saini-Chohan et al.   JOURNAL OF LIPID RESEARCH

Liver TAG Transiently Decreases While PL n-3 and n-6 Fatty Acids are Persistently Elevated in Insulin Resistant Mice

(2008) Ludger Scheja et al.   LIPIDS