Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner

(2021) Franziska Kopietz et al.   BIOCHEMICAL JOURNAL

Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase

(2021) Ashley J. Ovens et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

(2021) Philipp Rhein et al.   Molecular Metabolism

The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport

(2020) Jonas R. Knudsen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3

(2020) Xinmiao Ji et al.   FEBS Open Bio

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

(2019) Apirat Chaikuad et al.   BIOCHEMICAL JOURNAL

AMPK and TBC1D1 Regulate Muscle Glucose Uptake After - But Not During - Exercise and Contraction

(2019) Rasmus Kjøbsted et al.   DIABETES

AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis

(2019) Omar J. Katwan et al.   BIOCHEMICAL JOURNAL

Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity

(2019) Morten Dall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of human ENT1 in complex with adenosine reuptake inhibitors

(2019) Nicholas J. Wright et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

(2019) Caterina Collodet et al.   FASEB JOURNAL

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycaemia

(2019) Aphrodite T Choumessi et al.   BIOCHEMICAL JOURNAL

Regulation of hepatic glucose production and AMPK by AICAR but not metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)

(2018) Lisa Logie et al.   DIABETES OBESITY & METABOLISM

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965

(2018) Toby A. Dite et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development

(2018) Nadia Boudaba et al.   EBioMedicine

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase

(2018) Anastasiya Strembitska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

(2017) Toby A. Dite et al.   Nature Communications

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

(2016) Laurent Bultot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

(2016) Qiaoli Chen et al.   DIABETOLOGIA

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

(2014) Serge Ducommun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

(2014) Roger W. Hunter et al.   CHEMISTRY & BIOLOGY

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice

(2014) Hayley M. O’Neill et al.   DIABETOLOGIA

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

(2014) Matthew F. Calabrese et al.   STRUCTURE

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

(2011) Noriko Handa et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking

(2011) Shuai Chen et al.   Cell Metabolism

The specificities of small molecule inhibitors of the TGFß and BMP pathways

(2011) Janis Vogt et al.   CELLULAR SIGNALLING

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis

(2009) Danzhi Huang et al.   BIOINFORMATICS

DOCK 6: Combining techniques to model RNA-small molecule complexes

(2009) P. T. Lang et al.   RNA

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

(2008) Kei Sakamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators

(2008) Bruno Guigas et al.   IUBMB LIFE