Dual disruption of eNOS and ApoE gene accelerates kidney fibrosis and senescence after injury

Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Boris Bikbov et al.   LANCET

Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury

(2019) Andreas Hedblom et al.   Cell Death & Disease

Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair

(2019) Guillaume Canaud et al.   Science Translational Medicine

Cellular Senescence in the Kidney

(2019) Marie-Helena Docherty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses

(2019) Seiji Kishi et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel protein synthesis–breakdown complexes: TASCCed with fibrosis after G2-M arrest

(2019) Madhav C. Menon et al.   KIDNEY INTERNATIONAL

Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice

(2018) Takeshi Mitsuhashi et al.   Journal of Atherosclerosis and Thrombosis

Heme oxygenase-1 induction attenuates senescence in chronic obstructive pulmonary disease lung fibroblasts by protecting against mitochondria dysfunction

(2018) Benjamin Even et al.   AGING CELL

Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence

(2018) Huitong Shan et al.   EBioMedicine

The metabolic syndrome and chronic kidney disease

(2017) Xin Zhang et al.   Translational Research

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Mammalian Target of Rapamycin Mediates Kidney Injury Molecule 1-Dependent Tubule Injury in a Surrogate Model

(2015) W. Yin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Zinc- 2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart

(2015) I. Sorensen-Zender et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury

(2015) Seiji Kishi et al.   EBioMedicine

Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction

(2014) Yoshikazu Johmura et al.   MOLECULAR CELL

Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury

(2014) G. Canaud et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis

(2013) Benjamin D. Humphreys et al.   JOURNAL OF CLINICAL INVESTIGATION

Life Cycle Analysis of Kidney Gene Expression in Male F344 Rats

(2013) Joshua C. Kwekel et al.   PLoS One

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

SOX9 Protein Induces a Chondrogenic Phenotype of Mesangial Cells and Contributes to Advanced Diabetic Nephropathy

(2011) Seiji Kishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Cell Senescence in the Aging Kidney

(2010) H. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-β-mediated ERK signaling

(2010) B Kong et al.   ONCOGENE

Zag Expression during Aging Suppresses Proliferation after Kidney Injury

(2008) R. Schmitt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY