Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury

The macrophage heme-heme oxygenase-1 system and its role in inflammation

(2018) Vijith Vijayan et al.   BIOCHEMICAL PHARMACOLOGY

Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling

(2018) Wenwei Luo et al.   Aging-US

Heme oxygenase-1 induction attenuates senescence in chronic obstructive pulmonary disease lung fibroblasts by protecting against mitochondria dysfunction

(2018) Benjamin Even et al.   AGING CELL

Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence

(2017) Marieke Aarts et al.   GENES & DEVELOPMENT

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Cellular senescence impact on immune cell fate and function

(2016) Rita Vicente et al.   AGING CELL

Senescence associated macrophages and “macroph-aging”: are they pieces of the same puzzle?

(2016) Francesco Prattichizzo et al.   Aging-US

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Heme oxygenase-1 in macrophages controls prostate cancer progression

(2015) Zsuzsanna Nemeth et al.   Oncotarget

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling

(2014) Kavita Bisht et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice

(2014) G. Kovtunovych et al.   BLOOD

Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation

(2014) Barbara Wegiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme Oxygenase-1: A Metabolic Nike

(2013) Barbara Wegiel et al.   ANTIOXIDANTS & REDOX SIGNALING

Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

(2013) B. Wegiel et al.   CANCER RESEARCH

Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer

(2013) L Bracci et al.   CELL DEATH AND DIFFERENTIATION

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

p16INK4a Exerts an Anti-Inflammatory Effect through Accelerated IRAK1 Degradation in Macrophages

(2012) Y. Murakami et al.   JOURNAL OF IMMUNOLOGY

The social network of carbon monoxide in medicine

(2012) Barbara Wegiel et al.   TRENDS IN MOLECULAR MEDICINE

Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

(2012) Rasmus Larsen et al.   Frontiers in Pharmacology

p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages

(2011) C. Cudejko et al.   BLOOD

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Biliverdin reductase A in the prevention of cellular senescence against oxidative stress

(2011) Sung Young Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein

(2011) L. E. Otterbein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: Relevance for anti-aging intervention

(2010) Cristovao F. Lima et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease

(2009) Danielle Morse et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell Surface Biliverdin Reductase Mediates Biliverdin-induced Anti-inflammatory Effects via Phosphatidylinositol 3-Kinase and Akt

(2009) Barbara Wegiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme oxygenase-1–derived carbon monoxide enhances the host defense response to microbial sepsis in mice

(2008) Su Wol Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

Hematopoietic Stem Cells and the Aging Hematopoietic System

(2008) Roi Gazit et al.   SEMINARS IN HEMATOLOGY