Review
Biochemistry & Molecular Biology
Amirhossein Sahebkar, Nasim Kiaie, Armita Mahdavi Gorabi, Massimo R. Mannarino, Vanessa Bainaconi, Tannaz Jamialahmadi, Matteo Pirro, Maciej Banach
Summary: Pitavastatin is a unique lipophilic statin with pleiotropic effects, including reducing inflammation and oxidative stress. It appears to be the safest statin based on available studies, with multiple therapeutic effects that make it an interesting option for the treatment of various human diseases.
PROGRESS IN LIPID RESEARCH
(2021)
Article
Medicine, Research & Experimental
Caixia Zhou, Yashu Kuang, Qinyu Li, Yunhao Duan, Xiuxiang Liu, Jinnan Yue, Xiaoli Chen, Jie Liu, Yuzhen Zhang, Lin Zhang
Summary: This study demonstrates that EC-expressing S1pr2 tightly controls post-ischemic angiogenesis and blood flow perfusion recovery. The inhibition of S1pr2 can enhance post-ischemic angiogenesis and improve blood flow in peripheral artery disease, offering a novel therapeutic intervention.
Article
Biochemistry & Molecular Biology
Miriam M. Cortese-Krott, Tatsiana Suvorava, Francesca Leo, Sophia K. Heuser, Anthea LoBue, Junjie Li, Stefanie Becher, Rebekka Schneckmann, Tanu Srivrastava, Ralf Erkens, Georg Wolff, Joachim P. Schmitt, Maria Grandoch, Jon O. Lundberg, John Pernow, Brant E. Isakson, Eddie Weitzberg, Malte Kelm
Summary: This study reveals that red blood cell endothelial nitric oxide synthase (RBC eNOS) plays a role in limiting infarct size in acute myocardial infarction (AMI) and regulates coronary blood flow and cardiac function. These findings suggest that RBC eNOS signaling may represent a novel target for interventions in ischemia/reperfusion after myocardial infarction.
Article
Pharmacology & Pharmacy
B. Onal, M. Alaylioglu, G. Yenmis, A. S. Dogan, E. Dursun, D. Gezen-Ak, M. Ugurlucan
Summary: This study compared the efficacy of atorvastatin and pitavastatin in an inflammation model. The results showed that pitavastatin had superior inhibitory effects on certain pro-inflammatory cytokines compared to atorvastatin. This suggests that pitavastatin may be more suitable for controlling cardiovascular diseases caused by atherosclerosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qin Zhou, Tao Tu, Shi Tai, Liang Tang, Hui Yang, Zhaowei Zhu
Summary: Recent studies have demonstrated that HMGB1 plays a crucial role in endothelial cells, influencing Akt/eNOS pathway and ROS production. Deletion of HMGB1 in endothelial cells resulted in decreased EDR and impaired angiogenesis, which could be partly rescued by superoxide dismutase.
Review
Cardiac & Cardiovascular Systems
Bingbing Lin, Juan Yang, Yuwei Song, Guohui Dang, Juan Feng
Summary: Atherosclerosis serves as the common pathological foundation for myocardial infarction and ischemic stroke. Exosomes released by different cell types play a crucial role in cell-to-cell communication, affecting the function of target cells. The potential applications of exosomes in clinical diagnosis and treatment are significant.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Jeffrey Triska, Neil Maitra, Matthew R. Deshotels, Faris Haddadin, Dominick J. Angiolillo, Gemma Vilahur, Hani Jneid, Dan Atar, Yochai Birnbaum
Summary: This review summarizes the pleiotropic effects of ticagrelor, including attenuation of ischemia-reperfusion injury, inflammation, adverse cardiac remodeling, and atherosclerosis. Ticagrelor exerts these effects by increasing local interstitial adenosine levels and activating downstream cardio-protective molecules. High-dose aspirin and caffeine, as well as statins, may mediate the attenuation and augmentation of these effects.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Pharmacology & Pharmacy
Lia Farahi, Satyesh K. Sinha, Aldons J. Lusis
Summary: Atherosclerosis is a chronic inflammatory disease that involves the recruitment and differentiation of monocytes into macrophages in response to inflammatory insults. Macrophages play critical roles in tissue damage, wound healing, and regression of atherosclerotic lesions, and their phenotypes are influenced by various stimuli. Recent advances in single-cell sequencing have revealed the heterogeneity of macrophages in lesions, shedding light on potential macrophage-based therapies for atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Steven K. K. Grinspoon, Kathleen V. V. Fitch, Markella V. V. Zanni, Carl J. J. Fichtenbaum, Triin Umbleja, Judith A. A. Aberg, Edgar T. T. Overton, Carlos D. D. Malvestutto, Gerald S. S. Bloomfield, Judith S. S. Currier, Esteban Martinez, Jhoanna C. C. Roa, Marissa R. R. Diggs, Evelynne S. S. Fulda, Kayla Paradis, Stephen D. D. Wiviott, Borek Foldyna, Sara E. E. Looby, Patrice Desvigne-Nickens, Beverly Alston-Smith, Jorge Leon-Cruz, Sara McCallum, Udo Hoffmann, Michael T. T. Lu, Heather J. J. Ribaudo, Pamela S. S. Douglas, REPRIEVE Investigators
Summary: This phase 3 trial investigated primary prevention strategies for cardiovascular disease in HIV-infected individuals receiving antiretroviral therapy. The results showed that participants receiving pitavastatin had a lower risk of major adverse cardiovascular events compared to those receiving placebo over a median follow-up of 5.1 years.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Ting-Wei Kao, Chin-Chou Huang
Summary: SGLT2 inhibitors have been recognized as effective therapy for heart failure and are associated with blood pressure reduction through various mechanisms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ahmed Aboulgheit, Catherine Karbasiafshar, Zhiqi Zhang, Mohamed Sabra, Guangbin Shi, Aja Tucker, Neel Sodha, M. Ruhul Abid, Frank W. Sellke
Summary: Dietary supplementation with L. plantarum-applesauce enhances Nrf2-mediated antioxidant signaling cascade in ischemic myocardium, improving diastolic function and increasing eNOS expression. Although it is associated with a reduction in hypoxic stimuli and decreased vascular density, the net effect is an increase in antioxidant activity and eNOS expression, resulting in improved diastolic function.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Plant Sciences
Liangrong Jiang, Hui Zhong, Xianbin Jiang, Jiaoping Zhang, Rongyu Huang, Furong Liao, Yaqin Deng, Qingqing Liu, Yumin Huang, Houcong Wang, Yi Tao, Jingsheng Zheng
Summary: In this study, the candidate gene GSE5 was identified and characterized as a major quantitative trait gene for rice chalkiness. The results showed that GSE5 had pleiotropic effects and regulated both chalkiness and grain shape. Genetic analysis revealed that GSE5 played a dominant role in grain length and a semi-dominant role in grain width and chalkiness. The study also revealed the regulatory network of GSE5 on carbon and protein metabolism, providing insights into the mechanisms underlying chalkiness formation in rice.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Nutrition & Dietetics
Emilio Ros, Annapoorna Singh, James H. O'Keefe
Summary: Nuts are energy-dense foods with a complex mix of beneficial nutrients and bioactives that positively influence metabolic and vascular physiology pathways, improving cardiovascular risk factors and a variety of health outcomes. Studies show that nut consumption is associated with lower cancer incidence and mortality, improved cognitive function, and reduced risk of stroke.
Article
Immunology
Shimaa Khaled, Rania R. Abdelaziz, Ghada M. Suddek, Sally L. Elshaer
Summary: This study evaluates the angiogenic potential of candesartan, an angiotensin-II receptor blocker, in an experimental model of vascular complications associated with type-2 diabetes. The results demonstrate that candesartan is able to reverse ischemic insult and induce reparative angiogenesis in diabetic rats with peripheral arterial diseases. This finding could pave the way for the therapeutic use of candesartan in diabetic patients experiencing vascular complications in clinical settings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Lise Voland, Meng Yuan, Simon Lecoutre, Jean Debedat, Veronique Pelloux, Marion Pradeau, Emavieve Coles, Fatiha Merabtene, Cheng Zhang, Adil Mardinoglu, Tiphaine Le Roy, Hedi Soula, Karine Clement
Summary: Combination therapies targeting obesity and its comorbidities show promising results. The gut microbiota composition and function are altered in obesity. Previous studies have shown that a combination of a prebiotic and vitamin B7/B8 can reduce fat accumulation and hyperglycemia. This study further reveals that the combination treatment can downregulate lipid transport genes, reduce adipocyte size, decrease lipid metabolism gene expression, and inhibit inflammatory gene and protein expression, leading to improved metabolism in obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Masashi Ishizu, Hiroyasu Mori, Mami Ohishi, Akio Kuroda, Yuko Akehi, Sumiko Yoshida, Ken-ichi Aihara, Motohiro Aiba, Tomoharu Kawano, Seiichi Hashida, Munehide Matsuhisa
Summary: This study aimed to evaluate the effectiveness of urinary adiponectin as a biomarker for predicting the decline of renal function in patients with diabetes. The results showed a positive correlation between urinary high molecular weight adiponectin and declining renal function in diabetic patients.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Urology & Nephrology
Hirofumi Hamano, Yasumasa Ikeda, Mitsuhiro Goda, Keijo Fukushima, Seiji Kishi, Masayuki Chuma, Michiko Yamashita, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Yoshito Zamami, Yuya Horinouchi, Yuki Izawa-Ishizawa, Licht Miyamoto, Keisuke Ishizawa, Hiromichi Fujino, Toshiaki Tamaki, Ken-ichi Aihara, Koichiro Tsuchiya
Summary: Research suggests that diphenhydramine may serve as a novel treatment for cisplatin-induced kidney toxicity by inhibiting cell death and reducing oxidative stress to alleviate kidney injury, with clinical evidence from patients supporting this finding.
KIDNEY INTERNATIONAL
(2021)
Article
Oncology
Kenta Yagi, Marin Mitstui, Yoshito Zamami, Takahiro Niimura, Yuki Izawa-Ishizawa, Mitsuhiro Goda, Masayuki Chuma, Kimiko Fukunaga, Takahiro Shibata, Shunsuke Ishida, Takumi Sakurada, Naoto Okada, Hirofumi Hamano, Yuya Horinouchi, Yasumasa Ikeda, Hiroaki Yanagawa, Keisuke Ishizawa
Summary: In this study, it was found that the use of proton pump inhibitors in bevacizumab-treated patients is associated with a lower treatment response, possibly due to PPIs inducing VEGF gene expression. Therefore, while PPIs may prevent hypertension in patients, they may reduce the anti-tumoral effects of bevacizumab.
Article
Endocrinology & Metabolism
Yukari Mitsui, Akio Kuroda, Masashi Ishizu, Hiroyasu Mori, Kiyoe Kurahashi, Takeshi Kondo, Sumiko Yoshida, Yuko Akehi, Ken-ichi Aihara, Itsuro Endo, Masahiro Abe, Munehide Matsuhisa
Summary: The study found that the average percentage of total daily basal insulin dose to total daily insulin dose in patients with type 1 diabetes on multiple daily injections (MDI) was approximately 24%. The percentage was positively correlated with body mass index (BMI) and negatively correlated with age at onset and at examination.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Kenji Nishimura, Kensei Taguchi, Seiji Kishi, Craig R. Brooks, Arisa Ochi, Hiroyuki Kadoya, Yasumasa Ikeda, Masashi Miyoshi, Masanori Tamaki, Hideharu Abe, Ken-ichi Aihara, Naoki Kashihara, Kojiro Nagai
Summary: The relationship between cellular senescence and fibrosis in the kidney is being elucidated and identified as a therapeutic target. Findings indicate that mice with endothelial dysfunction and dyslipidemia are more susceptible to kidney fibrosis and accelerated senescence, emphasizing the importance of managing lifestyle-related diseases for CKD prevention from a young age.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Tomoyo Hara, Ryoko Uemoto, Akiko Sekine, Yukari Mitsui, Shiho Masuda, Kiyoe Kurahashi, Sumiko Yoshida, Toshiki Otoda, Tomoyuki Yuasa, Akio Kuroda, Yasumasa Ikeda, Itsuro Endo, Soichi Honda, Katsuhiko Yoshimoto, Akira Kondo, Toshiaki Tamaki, Toshio Matsumoto, Munehide Matsuhisa, Masahiro Abe, Ken-ichi Aihara
Summary: The study revealed an inverse correlation between plasma HCII activity and glomerular injury in diabetic patients, suggesting HCII as a potential predictive factor for early-stage DKD development.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Letter
Hematology
Yousuke Kaneko, Motoki Sugasaki, Naoto Okada, Mako Niimi, Saya Yasui, Taiki Hori, Ken-ichi Aihara, Makoto Takishita, Masahiro Abe, Shingen Nakamura
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Tomoyuki Yuasa, Yasunori Takata, Nanako Aki, Kotaro Kunimi, Miki Satoh, Mari Nii, Yoshihiko Izumi, Toshiki Otoda, Seiichi Hashida, Haruhiko Osawa, Ken-ichi Aihara
Summary: The study found a positive correlation between sIR levels and estrogen levels in pregnant women, with a significant increase of sIR levels in late pregnancy. Estradiol-induced IR cleavage is regulated by calpain 2 and gamma-secretase, with a synergic effect of estrogen and high glucose levels on IR cleavage.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Letter
Hematology
Shingen Nakamura, Motoki Sugasaki, Masayoshi Souri, Hirohito Akazawa, Maiko Sogawa, Taiki Hori, Hiroki Yamagami, Makoto Takishita, Ken-ichi Aihara, Masahiro Abe, Atsushi Yasumoto, Eriko Morishita, Akitada Ichinose
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Endocrinology & Metabolism
Asami Okada, Misuzu Yamada-Yamashita, Yukari Tominaga, Kyoka Jo, Hiroyasu Mori, Reiko Suzuki, Masashi Ishizu, Motoyuki Tamaki, Yuko Akehi, Yuichi Takashi, Daisuke Koga, Eisuke Shimokita, Fuminori Tanihara, Kiyoe Kurahashi, Sumiko Yoshida, Yukari Mitsui, Shiho Masuda, Itsuro Endo, Ken-Ichi Aihara, Shoji Kagami, Masahiro Abe, Kevin Ferreri, Yoshio Fujitani, Munehide Matsuhisa, Akio Kuroda
Summary: Several research groups have reported methods for quantifying pancreatic beta cell injury by measuring CpG unmethylation of the insulin gene in circulation using digital droplet PCR or next-generation sequencing. The novel method developed in this study can detect four CpG unmethylations of the insulin gene, showing high linearity and the ability to detect a single copy of unmethylated insulin DNA.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Aoi Suenaga, Yasuyuki Seto, Masafumi Funamoto, Masaki Imanishi, Koichiro Tsuchiya, Yasumasa Ikeda
Summary: This study investigated the effects of TJ-17, a traditional Japanese Kampo medicine, on chronic kidney disease (CKD). The results showed that TJ-17 could alleviate renal injury, inflammation, and fibrosis in a mouse model of CKD induced by folic acid. It has a potential preventive effect on CKD.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Toshiki Otoda, Akiko Sekine, Ryoko Uemoto, Seijiro Tsuji, Tomoyo Hara, Motoyuki Tamaki, Tomoyuki Yuasa, Toshiaki Tamaki, Munehide Matsuhisa, Ken-ichi Aihara
Summary: Large-scale clinical trials have shown that SGLT2 inhibitors can reduce proteinuria in diabetic kidney disease. This study aimed to investigate the factors associated with a reduction in proteinuria following SGLT2 inhibitor administration, and found that decreased albuminuria levels were associated with decreased serum TNFR levels in patients with type 2 diabetes.
Article
Biochemistry & Molecular Biology
Saya Yasui, Yousuke Kaneko, Hiroki Yamagami, Minae Hosoki, Taiki Hori, Akihiro Tani, Tomoyo Hara, Kiyoe Kurahashi, Takeshi Harada, Shingen Nakamura, Toshiki Otoda, Tomoyuki Yuasa, Hiroyasu Mori, Akio Kuroda, Itsuro Endo, Munehide Matsuhisa, Takeshi Soeki, Ken-ichi Aihara
Summary: This study aimed to investigate the association between DHEAS and the development of skeletal muscle disorders in individuals with type 2 diabetes. The results showed a positive association between DHEAS level and handgrip strength, but no association with skeletal muscle mass index or gait speed. Multiple logistic regression analysis revealed an inverse association between DHEAS level and dynapenia prevalence, but no association with pre-sarcopenia or sarcopenia prevalence. A significant association between DHEAS level and dynapenia was found in males but not in females.
Article
Biochemistry & Molecular Biology
Hiroki Yamagami, Tomoyo Hara, Saya Yasui, Minae Hosoki, Taiki Hori, Yousuke Kaneko, Yukari Mitsui, Kiyoe Kurahashi, Takeshi Harada, Sumiko Yoshida, Shingen Nakamura, Toshiki Otoda, Tomoyuki Yuasa, Akio Kuroda, Itsuro Endo, Munehide Matsuhisa, Masahiro Abe, Ken-ichi Aihara
Summary: The study confirms the association between the progression of diabetic kidney disease (DKD) and the accumulation of advanced glycation end products. Measuring skin autofluorescence (SAF) can serve as an indicator of the severity of DKD. The study also finds a positive correlation between SAF and urine liver-type fatty acid-binding protein (uLFABP), but no association with urine albumin-to-creatinine ratio (uACR).
Article
Medicine, Research & Experimental
Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Masataka Sata
Summary: This case report describes a middle-aged man with congenital hypogonadotropic hypogonadism (HH) who had severe coronary artery disease complicated with metabolic disorders.
JOURNAL OF MEDICAL INVESTIGATION
(2021)