The application of cytokeratin-18 as a biomarker for drug-induced liver injury

The significance of IL-28B and CK-18 M30 levels in the diagnosis of non-alcoholic steatohepatitis in SD rats

(2020) Guangrong Dai et al.   PATHOLOGY RESEARCH AND PRACTICE

Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities

(2019) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Enoxaparin prevents fibrin accumulation in liver tissues and attenuates methotrexate-induced liver injury in rats

(2019) Mohamed G. Ewees et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Metabolomics and Cytokine Analysis for Identification of Severe Drug-Induced Liver Injury

(2019) Zhongyang Xie et al.   JOURNAL OF PROTEOME RESEARCH

Clinical prospects of biomarkers for the early detection and/or prediction of organ injury associated with pharmacotherapy

(2019) Soichiro Tajima et al.   BIOCHEMICAL PHARMACOLOGY

Keratin 18 is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis

(2019) Vatsalya Vatsalya et al.   Clinical Gastroenterology and Hepatology

Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort

(2018) Rachel J. Church et al.   HEPATOLOGY

Safety data and withdrawal of hepatotoxic drugs

(2018) Samy Babai et al.   THERAPIE

Animal models of drug-induced liver injury

(2018) Mitchell R. McGill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma

(2018) Leonardo Lorente   WORLD JOURNAL OF GASTROENTEROLOGY

A Performance Evaluation of Liver and Skeletal Muscle -Specific miRNAs in Rat Plasma to Detect Drug Induced Injury

(2018) Wendy J Bailey et al.   TOXICOLOGICAL SCIENCES

The transformation in biomarker detection and management of drug-induced liver injury

(2017) Rachel J. Church et al.   LIVER INTERNATIONAL

Assessment of Preclinical Liver and Skeletal Muscle Biomarkers Following Clofibrate Administration in Wistar Rats

(2017) Pierre Maliver et al.   TOXICOLOGIC PATHOLOGY

Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker

(2017) M. Hägg Olofsson et al.   Cancer Biomarkers

Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis

(2016) Kira Bettermann et al.   Oncotarget

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

(2016) Franck A. Atienzar et al.   Biomed Research International

Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice

(2015) Lawrence A. Scheving et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Drug-Induced Liver Injury

(2015) Kurt Fisher et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Poor Inter-test Reliability Between CK18 Kits as a Biomarker of NASH

(2015) Carolina F. M. G. Pimentel et al.   DIGESTIVE DISEASES AND SCIENCES

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

(2015) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury

(2014) Mercedes Robles–Diaz et al.   GASTROENTEROLOGY

Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: Results of a double-blind randomized clinical trial

(2013) Kevin M. Flanigan et al.   NEUROMUSCULAR DISORDERS

Chemotherapy-Associated Liver Injury in Patients with Colorectal Liver Metastases: A Systematic Review and Meta-analysis

(2012) Stuart M. Robinson et al.   ANNALS OF SURGICAL ONCOLOGY

Pharmacogenomics Knowledge for Personalized Medicine

(2012) M Whirl-Carrillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

A Performance Evaluation of Three Drug-Induced Liver Injury Biomarkers in the Rat: Alpha-Glutathione S-Transferase, Arginase 1, and 4-Hydroxyphenyl-Pyruvate Dioxygenase

(2012) Wendy J. Bailey et al.   TOXICOLOGICAL SCIENCES

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Systematic review: caspase-cleaved fragments of cytokeratin 18 - the promises and challenges of a biomarker for chronic liver disease

(2009) Y. YILMAZ   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury

(2009) Udayan Apte et al.   AMERICAN JOURNAL OF PATHOLOGY

Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas

(2009) Anna Kakehashi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Circulating Biomarkers of Cell Death After Treatment with the BH-3 Mimetic ABT-737 in a Preclinical Model of Small-Cell Lung Cancer

(2008) D. Micha et al.   CLINICAL CANCER RESEARCH

Using controlled clinical trials to learn more about acute drug-induced liver injury

(2008) Paul B. Watkins et al.   HEPATOLOGY