Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging

Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin

(2021) Zachary S. Clayton et al.   HYPERTENSION

Measuring Arterial Stiffness in Animal Experimental Studies

(2020) Mark Butlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

(2020) Vienna E. Brunt et al.   HYPERTENSION

Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening

(2020) Rachel A. Gioscia-Ryan et al.   GeroScience

Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐induced vascular dysfunction, mitochondrial oxidative stress, and inflammation in mice

(2020) Rachel A. Gioscia‐Ryan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice

(2019) Vienna E. Brunt et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Therapeutic Potential of Apigenin

(2019) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apigenin and its methylglyoxal-adduct inhibit advanced glycation end products-induced oxidative stress and inflammation in endothelial cells

(2019) Qian Zhou et al.   BIOCHEMICAL PHARMACOLOGY

Short‐term interleukin‐37 treatment improves vascular endothelial function, endurance exercise capacity, and whole‐body glucose metabolism in old mice

(2019) Dov B. Ballak et al.   AGING CELL

Apigenin prevent Abdominal Aortic Aneurysms Formation by Inhibiting the NF-κB Signaling Pathway

(2019) Dongyu Li et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice

(2018) Rachel A. Gioscia-Ryan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

(2016) Lisa A. Lesniewski et al.   AGING CELL

Vascular endothelium – Gatekeeper of vessel health

(2016) Paul A. Cahill et al.   ATHEROSCLEROSIS

Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats

(2016) Bei Ren et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Guide for the Care and Use of Laboratory Animals

(2016)   ILAR JOURNAL

Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose

(2016) Weiwei Qin et al.   VASCULAR PHARMACOLOGY

Lanatoside C Promotes Foam Cell Formation and Atherosclerosis

(2016) Huairui Shi et al.   Scientific Reports

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial quality control and age-associated arterial stiffening

(2014) Thomas J. LaRocca et al.   EXPERIMENTAL GERONTOLOGY

Arterial Stiffness and Hypertension

(2014) Gary F. Mitchell   HYPERTENSION

Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion

(2014) Shumin Ding et al.   International Journal of Nanomedicine

Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries

(2014) Douglas R. Seals   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

(2014) Rachel A. Gioscia-Ryan et al.   JOURNAL OF PHYSIOLOGY-LONDON

The autophagy enhancer spermidine reverses arterial aging

(2013) Thomas J. LaRocca et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Curcumin ameliorates arterial dysfunction and oxidative stress with aging

(2012) Bradley S. Fleenor et al.   EXPERIMENTAL GERONTOLOGY

Translational evidence that impaired autophagy contributes to arterial ageing

(2012) Thomas J. LaRocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Elastin in Large Artery Stiffness and Hypertension

(2012) Jessica E. Wagenseil et al.   Journal of Cardiovascular Translational Research

Mechanisms Involved in the Aging-Induced Vascular Dysfunction

(2012) Mariam El Assar et al.   Frontiers in Physiology

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging

(2011) Amy L. Sindler et al.   AGING CELL

Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

(2011) Bradley S. Fleenor et al.   AGING CELL

Aging and vascular endothelial function in humans

(2011) Douglas R. Seals et al.   CLINICAL SCIENCE

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor  B and Forkhead Box O Phosphorylation

(2011) L. A. Lesniewski et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Arterial Stiffness and Cardiovascular Events

(2010) Gary F. Mitchell et al.   CIRCULATION

Evaluation of foam cell formation in cultured macrophages: an improved method with Oil Red O staining and DiI-oxLDL uptake

(2010) Suowen Xu et al.   CYTOTECHNOLOGY

Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness

(2010) Charalambos Vlachopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake

(2009) Jie Cao et al.   BRITISH JOURNAL OF NUTRITION

Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase

(2009) Jessica R. Durrant et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY