Microbial reconstitution improves aging-driven lacrimal gland circadian dysfunction

Light cycle phase advance as a model for jet lag reprograms the circadian rhythms of murine extraorbital lacrimal glands

(2021) Shenzhen Huang et al.   Ocular Surface

Identification of lacrimal gland postganglionic innervation and its regulation of tear secretion

(2020) Kai Jin et al.   AMERICAN JOURNAL OF PATHOLOGY

Gut dysbiosis is prevailing in Sjögren’s syndrome and is related to dry eye severity

(2020) Jayoon Moon et al.   PLoS One

Sexual-dimorphism in human immune system aging

(2020) Eladio J. Márquez et al.   Nature Communications

Interaction between microbiota and immunity in health and disease

(2020) Danping Zheng et al.   CELL RESEARCH

The Landscape of Adaptive Evolution of a Gut Commensal Bacteria in Aging Mice

(2020) Hugo C. Barreto et al.   CURRENT BIOLOGY

A neurotransmitter produced by gut bacteria modulates host sensory behaviour

(2020) Michael P. O’Donnell et al.   NATURE

Type 1 diabetes mellitus impairs diurnal oscillations in murine extraorbital lacrimal glands

(2020) Xinwei Jiao et al.   Ocular Surface

A brain-wide atlas of synapses across the mouse lifespan

(2020) Mélissa Cizeron et al.   SCIENCE

Sexual dimorphism in body clocks

(2020) Seán T. Anderson et al.   SCIENCE

The IL-23/IL-17 pathway in human chronic inflammatory diseases—new insight from genetics and targeted therapies

(2019) Elisabetta Bianchi et al.   GENES AND IMMUNITY

Relationship between the microbiome and ocular health

(2019) Kara M. Cavuoto et al.   Ocular Surface

Age-associated changes in human tear proteome

(2019) Janika Nättinen et al.   Clinical Proteomics

From Healthy Aging to Frailty: In Search of the Underlying Mechanisms

(2019) Paola Brivio et al.   CURRENT MEDICINAL CHEMISTRY

Tear Metabolomics in Dry Eye Disease: A Review

(2019) Mazyar Yazdani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

(2019) Clea Bárcena et al.   NATURE MEDICINE

Gut microbes, ageing & organ function: a chameleon in modern biology?

(2019) Musarrat Maisha Reza et al.   EMBO Molecular Medicine

Antibiotic-induced dysbiosis of gut microbiota impairs corneal development in postnatal mice by affecting CCR2 negative macrophage distribution

(2019) Mingjuan Wu et al.   Mucosal Immunology

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3

(2019) Zheng Kuang et al.   SCIENCE

Presbyopia and the aging eye: Existing refractive approaches and their potential impact on dry eye signs and symptoms

(2019) E Lafosse et al.   Contact Lens & Anterior Eye

Functional microbiome deficits associated with ageing: Chronological age threshold

(2019) Susana Ruiz‐Ruiz et al.   AGING CELL

Age related changes seen in human cornea in formalin fixed sections and on biomicroscopy in living subjects: A comparison

(2019) Samanta Taurone et al.   CLINICAL ANATOMY

The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome

(2019) Claudia M. Trujillo-Vargas et al.   Ocular Surface

Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice

(2019) Parag Kundu et al.   Science Translational Medicine

Alternative splicing in aging and longevity

(2019) Malini Bhadra et al.   HUMAN GENETICS

Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism

(2019) Katya Frazier et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genomics of circadian rhythms in health and disease

(2019) Filipa Rijo-Ferreira et al.   Genome Medicine

Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice

(2018) Changjun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective role of commensal bacteria in Sjögren Syndrome

(2018) Mahira Zaheer et al.   JOURNAL OF AUTOIMMUNITY

Generation of circadian rhythms in the suprachiasmatic nucleus

(2018) Michael H. Hastings et al.   NATURE REVIEWS NEUROSCIENCE

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

(2018) Kenneth A. Dyar et al.   CELL

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Antibiotic-Induced Dysbiosis of Gut Microbiota Impairs Corneal Nerve Regeneration by Affecting CCR2-Negative Macrophage Distribution

(2018) Jun Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

(2018) Benjamin D. Weger et al.   Cell Metabolism

Aging and the clock: Perspective from flies to humans

(2018) Aliza K. De Nobrega et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus

(2018) Taco A. van der Meulen et al.   JOURNAL OF AUTOIMMUNITY

The gut microbiome: Relationships with disease and opportunities for therapy

(2018) Juliana Durack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rhythms of life: circadian disruption and brain disorders across the lifespan

(2018) Ryan W. Logan et al.   NATURE REVIEWS NEUROSCIENCE

A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans

(2018) Nicolas Dutzan et al.   Science Translational Medicine

The aging clock: circadian rhythms and later life

(2017) Suzanne Hood et al.   JOURNAL OF CLINICAL INVESTIGATION

Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging

(2017) Rachael C. Kuintzle et al.   Nature Communications

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

(2016) Christoph A. Thaiss et al.   CELL

Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA)

(2016) Ray Zhang et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells

(2016) T G Coursey et al.   Mucosal Immunology

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome

(2016) Cintia S. de Paiva et al.   Scientific Reports

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

(2015) Vanessa Leone et al.   Cell Host & Microbe

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

(2015) Reiko Horai et al.   IMMUNITY

Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease

(2015) Yuan Gao et al.   JOURNAL OF IMMUNOLOGY

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

(2015) Cho-Yi Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock

(2015) Xue Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota and aging

(2015) P. W. OToole et al.   SCIENCE

Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice

(2014) Andrew J. McClellan et al.   AMERICAN JOURNAL OF PATHOLOGY

Aging: A Predisposition to Dry Eyes

(2014) Anushree Sharma et al.   Journal of Ophthalmology

Microbial shifts in the aging mouse gut

(2014) Morgan GI Langille et al.   Microbiome

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences

(2013) Morgan G I Langille et al.   NATURE BIOTECHNOLOGY

Age-Related Dysfunction of the Lacrimal Gland and Oxidative Stress

(2012) Takashi Kojima et al.   AMERICAN JOURNAL OF PATHOLOGY

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(2012) Juan Ding et al.   EXPERIMENTAL GERONTOLOGY

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(2012) Laurence S Lim et al.   LANCET

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

The Aging Lacrimal Gland: Changes in Structure and Function

(2012) Eduardo M. Rocha et al.   Ocular Surface

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

(2011) Lorna W. Harries et al.   AGING CELL

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Physiology of Circadian Entrainment

(2010) Diego A. Golombek et al.   PHYSIOLOGICAL REVIEWS

Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland

(2009) Kaijin Wu et al.   EXPERIMENTAL EYE RESEARCH

Neural regulation of lacrimal gland secretory processes: Relevance in dry eye diseases

(2009) Darlene A. Dartt   PROGRESS IN RETINAL AND EYE RESEARCH

GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition

(2008) Tija C. Jacob et al.   NATURE REVIEWS NEUROSCIENCE