REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons

Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF

(2021) Kaichi Yoshizaki et al.   EMBO REPORTS

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

(2021) BJ Ryan et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF

(2021) Federica Buffolo et al.   Cell Death & Disease

Context-Dependent Functions of E2F1: Cell Cycle, Cell Death, and DNA Damage Repair in Cortical Neurons

(2020) Yang Zhang et al.   MOLECULAR NEUROBIOLOGY

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

(2019) Katharina Meyer et al.   Cell Reports

Expression of p16 and p21 in the frontal association cortex of ALS / MND brains suggest neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease

(2019) Irina Vazquez‐Villaseñor et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Autophagy in Neurons

(2019) Andrea K.H. Stavoe et al.   Annual Review of Cell and Developmental Biology

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

(2019) James Chapman et al.   FEBS LETTERS

Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

(2019) Shoma Ishikawa et al.   AGING CELL

Regulation of lifespan by neural excitation and REST

(2019) Joseph M. Zullo et al.   NATURE

Autoantibodies to synapsin I sequestrate synapsin I and alter synaptic function

(2019) Anna Rocchi et al.   Cell Death & Disease

REST, a master transcriptional regulator in neurodegenerative disease

(2018) Jee-Yeon Hwang et al.   CURRENT OPINION IN NEUROBIOLOGY

Delivery of Brain-Derived Neurotrophic Factor by 3D Biocompatible Polymeric Scaffolds for Neural Tissue Engineering and Neuronal Regeneration

(2018) T. Limongi et al.   MOLECULAR NEUROBIOLOGY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

(2018) Przemyslaw Sapieha et al.   TRENDS IN CELL BIOLOGY

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

(2018) Clara Correia-Melo et al.   AGING CELL

REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity

(2017) F. Pecoraro-Bisogni et al.   MOLECULAR NEUROBIOLOGY

REST regulates the cell cycle for cardiac development and regeneration

(2017) Donghong Zhang et al.   Nature Communications

Plasma REST: a novel candidate biomarker of Alzheimer’s disease is modified by psychological intervention in an at-risk population

(2017) N J Ashton et al.   Translational Psychiatry

Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet

(2016) Anna Rocchi et al.   ACTA NEUROPATHOLOGICA

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

FoxO1-mediated autophagy is required for NK cell development and innate immunity

(2016) Shuo Wang et al.   Nature Communications

REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling

(2016) Zhiqi Song et al.   Oncotarget

The REST remodeling complex protects genomic integrity during embryonic neurogenesis

(2016) Tamilla Nechiporuk et al.   eLife

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

(2011) Catherine Coffinier et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT