Journal
NATURE REVIEWS RHEUMATOLOGY
Volume 15, Issue 5, Pages 254-255Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41584-019-0205-y
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- Lupus Research Alliance
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Sensing of cytosolic DNA by cyclic GMP-AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
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