Cation‐Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy

siRNA Drugs: Here to Stay

(2021) John J. Rossi et al.   MOLECULAR THERAPY

A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma

(2021) Priya Kumthekar et al.   Science Translational Medicine

Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

(2021) Jia Li et al.   Advanced Science

Charge Conversional Biomimetic Nanocomplexes as a Multifunctional Platform for Boosting Orthotopic Glioblastoma RNAi Therapy

(2020) Yanjie Liu et al.   NANO LETTERS

Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment

(2020) Yan Zou et al.   ADVANCED MATERIALS

Organic Spherical Nucleic Acids Facilitate NIR‐II Emitting Dye to Cross Blood‐Brain Barrier

(2020) Fan Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in siRNA delivery mediated by lipid-based nanoparticles

(2020) Sei Yonezawa et al.   ADVANCED DRUG DELIVERY REVIEWS

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

(2020) Wei Tao et al.   Science Translational Medicine

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

(2020) Yutong Zhou et al.   Science Advances

Strategies and materials of "SMART" non-viral vectors: Overcoming the barriers for brain gene therapy

(2020) Yan Li et al.   Nano Today

Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo

(2019) Dali Wang et al.   Science Advances

Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells

(2019) Yu Yi et al.   JOURNAL OF CONTROLLED RELEASE

The siRNAsome: A Cation-Free and Versatile Nanostructure for siRNA and Drug Co-delivery

(2019) Meng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stressing the Role of DNA as a Drug Carrier: Synthesis of DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides

(2019) Yuanyuan Guo et al.   ADVANCED MATERIALS

Microthrombus‐Targeting Micelles for Neurovascular Remodeling and Enhanced Microcirculatory Perfusion in Acute Ischemic Stroke

(2019) Yifei Lu et al.   ADVANCED MATERIALS

Ligand‐Installed Nanocarriers toward Precision Therapy

(2019) Peng Mi et al.   ADVANCED MATERIALS

ROS‐Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy

(2019) Meng Zheng et al.   ADVANCED MATERIALS

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

(2019) Jayesh A. Kulkarni et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

PLGA Spherical Nucleic Acids

(2018) Shengshuang Zhu et al.   ADVANCED MATERIALS

Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment

(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

DNA nanoclew templated spherical nucleic acids for siRNA delivery

(2018) Weimin Ruan et al.   CHEMICAL COMMUNICATIONS

Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy

(2018) Meng Zheng et al.   TRENDS IN BIOTECHNOLOGY

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

STAT3 Gene Silencing by Aptamer-siRNA Chimera as Selective Therapeutic for Glioblastoma

(2018) Carla Lucia Esposito et al.   Molecular Therapy-Nucleic Acids

A ribonucleoprotein octamer for targeted siRNA delivery

(2018) Wanyi Tai et al.   Nature Biomedical Engineering

Micelles with ultralow critical micelle concentration as carriers for drug delivery

(2018) Yang Lu et al.   Nature Biomedical Engineering

Efficient siRNA delivery with non-cationic carriers

(2018) Chun Kit K. Choi et al.   Nature Biomedical Engineering

Transport and interactions of nanoparticles in the kidneys

(2018) Bujie Du et al.   Nature Reviews Materials

RNA Micelles for the Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand

(2018) Hongran Yin et al.   ACS Nano

Boosting RNAi therapy for orthotopic glioblastoma with nontoxic brain-targeting chimaeric polymersomes

(2018) Yanan Shi et al.   JOURNAL OF CONTROLLED RELEASE

Adult Glioblastoma

(2017) Brian M. Alexander et al.   JOURNAL OF CLINICAL ONCOLOGY

Management of GBM: a problem of local recurrence

(2017) John P. Kirkpatrick et al.   JOURNAL OF NEURO-ONCOLOGY

Mechanical properties of PNIPAM based hydrogels: A review

(2017) Muhammad Abdul Haq et al.   Materials Science & Engineering C-Materials for Biological Applications

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression

(2017) Dou Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

(2017) Jia-Lin Huang et al.   Nature Communications

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

(2017) Yifeng Lei et al.   Nature Communications

Survival in glioblastoma: a review on the impact of treatment modalities

(2016) P. D. Delgado-López et al.   Clinical & Translational Oncology

Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle

(2016) Xuyu Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glioblastoma: pathology, molecular mechanisms and markers

(2015) Kenneth Aldape et al.   ACTA NEUROPATHOLOGICA

Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles

(2014) Hyun Jin Kim et al.   ACS Nano

Liposomal Spherical Nucleic Acids

(2014) Resham J. Banga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

(2014) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo

(2013) Huan Meng et al.   ACS Nano

Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma

(2013) J A Pezuk et al.   CANCER GENE THERAPY

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

(2013) S. A. Jensen et al.   Science Translational Medicine

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression

(2012) Shinji Kohsaka et al.   MOLECULAR CANCER THERAPEUTICS

Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane

(2012) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery

(2011) Ru Cheng et al.   JOURNAL OF CONTROLLED RELEASE

Polyvalent Nucleic Acid Nanostructures

(2011) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids

(2008) Dwight S. Seferos et al.   NANO LETTERS