Stressing the Role of DNA as a Drug Carrier: Synthesis of DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides

Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy

(2018) Changmai Chen et al.   MEDICINAL RESEARCH REVIEWS

A Molecular Recognition Approach To Synthesize Nucleoside Analogue Based Multifunctional Nanoparticles for Targeted Cancer Therapy

(2017) Dali Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid–Drug Conjugate for Enhancing Drug Delivery

(2017) Danielle Irby et al.   MOLECULAR PHARMACEUTICS

DNA Tetrahedron Delivery Enhances Doxorubicin-Induced Apoptosis of HT-29 Colon Cancer Cells

(2017) Guiyu Zhang et al.   Nanoscale Research Letters

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Bioproduction of Antibody–Drug Conjugate Payload Precursors by Engineered Cell Factories

(2017) Jie Wang et al.   TRENDS IN BIOTECHNOLOGY

Precision spherical nucleic acids for delivery of anticancer drugs

(2017) Danny Bousmail et al.   Chemical Science

A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

(2017) Fangfei Li et al.   Nature Communications

DNA Tetrahedron Delivery Enhances Doxorubicin-Induced Apoptosis of HT-29 Colon Cancer Cells

(2017) Guiyu Zhang et al.   Nanoscale Research Letters

Tumor-Penetrating Peptide-Modified DNA Tetrahedron for Targeting Drug Delivery

(2016) Zhiwei Xia et al.   BIOCHEMISTRY

Design Considerations for RNA Spherical Nucleic Acids (SNAs)

(2016) Stacey N. Barnaby et al.   BIOCONJUGATE CHEMISTRY

A multifunctional DNA origami as carrier of metal complexes to achieve enhanced tumoral delivery and nullified systemic toxicity

(2016) Yanyu Huang et al.   BIOMATERIALS

Discrete DNA three-dimensional nanostructures: the synthesis and applications

(2016) Xiao-rong Wu et al.   CHINESE JOURNAL OF POLYMER SCIENCE

pH-responsive polymer–drug conjugates: Design and progress

(2016) Xin Pang et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle

(2016) Xuyu Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

(2016) Kyoji Tsuchikama et al.   Protein & Cell

Postsynthetic Modification of DNA Phosphodiester Backbone for Photocaged DNAzyme

(2015) Xiaoyan Wang et al.   ACS Chemical Biology

Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles: A dual-functional strategy for paclitaxel delivery

(2015) Jinming Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Self-assembly of DNA Nanohydrogels with Controllable Size and Stimuli-Responsive Property for Targeted Gene Regulation Therapy

(2015) Juan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolving Strategies for Target Selection for Antibody-Drug Conjugates

(2015) Marc Damelin et al.   PHARMACEUTICAL RESEARCH

Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model

(2015) Patrick D. Halley et al.   Small

A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy

(2015) Thu Le Trinh et al.   PLoS One

DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

(2014) Qian Zhang et al.   ACS Nano

DNA-Templated Assembly of a Heterobivalent Quantum Dot Nanoprobe For Extra- and Intracellular Dual-Targeting and Imaging of Live Cancer Cells

(2014) Wei Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Aptamer-Polymer Hybrid Constructs for Programmed Drug Delivery into Specific Target Cells

(2014) Seung Soo Oh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combination of Small Molecule Prodrug and Nanodrug Delivery: Amphiphilic Drug–Drug Conjugate for Cancer Therapy

(2014) Ping Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

(2014) Fritz Eckstein   Nucleic Acid Therapeutics

A Spherical Nucleic Acid Platform Based on Self-Assembled DNA Biopolymer for High-Performance Cancer Therapy

(2013) Jing Zheng et al.   ACS Nano

Aptamers from Cell-Based Selection for Bioanalytical Applications

(2013) Weihong Tan et al.   CHEMICAL REVIEWS

Antibody–drug conjugates

(2013) Rachel S. Zolot et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates

(2013) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-associated click chemistry

(2013) Mohammad Mojibul Haque et al.   Science China-Chemistry

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties

(2012) Yong-Xing Zhao et al.   ACS Nano

Conjugation Reactions Involving Maleimides and Phosphorothioate Oligonucleotides

(2012) Albert Sánchez et al.   BIOCONJUGATE CHEMISTRY

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aptamer-Conjugated DNA Icosahedral Nanoparticles As a Carrier of Doxorubicin for Cancer Therapy

(2011) Microsugar Chang et al.   ACS Nano

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Selective Covalent Conjugation of Phosphorothioate DNA Oligonucleotides with Streptavidin

(2011) Kersten S. Rabe et al.   MOLECULES

Click chemistry with DNA

(2010) Afaf H. El-Sagheer et al.   CHEMICAL SOCIETY REVIEWS

Controlled Alignment of Multiple Proteins and Nanoparticles with Nanometer Resolution via Backbone-Modified Phosphorothioate DNA and Bifunctional Linkers

(2010) Jung Heon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY