Organ-on-a-chip technology for the study of the female reproductive system

A Lab-on-a-Chip system with an embedded porous membrane-based impedance biosensor array for nanoparticle risk assessment on placental Bewo trophoblast cells

(2020) Patrick Schuller et al.   SENSORS AND ACTUATORS B-CHEMICAL

Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models

(2020) Nina Maenhoudt et al.   Stem Cell Reports

Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology

(2020) Helena Malvezzi et al.   Journal of Translational Medicine

OvCa-Chip microsystem recreates vascular endothelium–mediated platelet extravasation in ovarian cancer

(2020) Biswajit Saha et al.   Blood Advances

Microphysiological systems of the placental barrier

(2020) Navein Arumugasaamy et al.   ADVANCED DRUG DELIVERY REVIEWS

Hemodynamic forces enhance decidualization via endothelial-derived prostaglandin E2 and prostacyclin in a microfluidic model of the human endometrium

(2019) Juan S Gnecco et al.   HUMAN REPRODUCTION

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Establishment and characterization of patient‐derived organoids from a young patient with cervical clear cell carcinoma

(2019) Yoshiaki Maru et al.   CANCER SCIENCE

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Assessing SSRIs’ effects on fetal cardiomyocytes utilizing placenta-fetus model

(2019) Navein Arumugasaamy et al.   Acta Biomaterialia

Drug transport across the human placenta: review of placenta-on-a-chip and previous approaches

(2019) Rajeendra L. Pemathilaka et al.   Interface Focus

Model Placental Barrier Phenotypic Response to Fluoxetine and Sertraline: A Comparative Study

(2019) Navein Arumugasaamy et al.   Advanced Healthcare Materials

Tetrafluoroethylene-Propylene Elastomer for Fabrication of Microfluidic Organs-on-Chips Resistant to Drug Absorption

(2019) Emi Sano et al.   Micromachines

Doxorubicin-induced toxicity to 3D-cultured rat ovarian follicles on a microfluidic chip

(2019) Aziz ur Rehman Aziz et al.   TOXICOLOGY IN VITRO

Ethical issues in genetic modification and why application matters

(2018) Megan Munsie et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Evaluation of an ovary-on-a-chip in large mammalian models: Species specificity and influence of follicle isolation status

(2018) Jennifer B. Nagashima et al.   Journal of Tissue Engineering and Regenerative Medicine

The ethics of maternal–fetal surgery

(2018) Frank A. Chervenak et al.   Seminars in Fetal & Neonatal Medicine

Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development

(2018) Samuel Sances et al.   Stem Cell Reports

Placental barrier-on-a-chip: modeling placental inflammatory responses to bacterial infection

(2018) Jianhua Qin et al.   ACS Biomaterials-Science & Engineering

Placental barrier-on-a-chip: modeling placental inflammatory responses to bacterial infection

(2018) Jianhua Qin et al.   ACS Biomaterials Science & Engineering

In vitro placenta barrier model using primary human trophoblasts, underlying connective tissue and vascular endothelium

(2018) Akihiro Nishiguchi et al.   BIOMATERIALS

Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube

(2018) Ying Xie et al.   Stem Cell Research

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

(2018) Sandra Haider et al.   Stem Cell Reports

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming

(2018) Marcia A. M. M. Ferraz et al.   Nature Communications

A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier

(2018) Fangchao Yin et al.   TOXICOLOGY IN VITRO

Self-contained, low-cost Body-on-a-Chip systems for drug development

(2017) Ying I Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

In vivo oxygen, temperature and pH dynamics in the female reproductive tract and their importance in human conception: a systematic review

(2017) Ka Ying Bonnie Ng et al.   HUMAN REPRODUCTION UPDATE

Tubal origin of ovarian cancer - the double-edged sword of haemoglobin

(2017) Shiou-Fu Lin et al.   JOURNAL OF PATHOLOGY

A microfluidics assay to study invasion of human placental trophoblast cells

(2017) Yassen Abbas et al.   Journal of the Royal Society Interface

Improved bovine embryo production in an oviduct-on-a-chip system: prevention of poly-spermic fertilization and parthenogenic activation

(2017) Marcia A. M. M. Ferraz et al.   LAB ON A CHIP

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

(2017) Ben M. Maoz et al.   LAB ON A CHIP

Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

(2017) Olivier Y. F. Henry et al.   LAB ON A CHIP

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

(2017) Monika Haemmerle et al.   Nature Communications

Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium

(2017) Nur Yucer et al.   Scientific Reports

Organ-on-a-Chip Systems for Women's Health Applications

(2017) Janna Nawroth et al.   Advanced Healthcare Materials

Risk of recurrent spontaneous preterm birth: a systematic review and meta-analysis

(2017) Courtney Phillips et al.   BMJ Open

Integration and validation of the ex vivo human placenta perfusion model

(2017) Sigrid Conings et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A Microfluidic Device for Culturing an Encapsulated Ovarian Follicle

(2017) Aziz Aziz et al.   Micromachines

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side

(2017) Elisa Giacomini et al.   Scientific Reports

Pumpless microfluidic system driven by hydrostatic pressure induces and maintains mouse spermatogenesis in vitro

(2017) Mitsuru Komeya et al.   Scientific Reports

Oviduct: roles in fertilization and early embryo development

(2016) Shuai Li et al.   JOURNAL OF ENDOCRINOLOGY

In vitroandin vivocorrelates of physiological and neoplastic human Fallopian tube stem cells

(2016) Yusuke Yamamoto et al.   JOURNAL OF PATHOLOGY

A microphysiological model of the human placental barrier

(2016) Cassidy Blundell et al.   LAB ON A CHIP

Animal Models to Study Placental Development and Function throughout Normal and Dysfunctional Human Pregnancy

(2016) Peta Grigsby   SEMINARS IN REPRODUCTIVE MEDICINE

Womb-on-a-chip biomimetic system for improved embryo culture and development

(2016) Kuo-Wei Chang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device

(2016) Mitsuru Komeya et al.   Scientific Reports

Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC-Derived Endothelial Cells

(2016) Hasan E. Abaci et al.   Advanced Healthcare Materials

Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection

(2015) Sheree L. Boulet et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Placenta-on-a-chip: a novel platform to study the biology of the human placenta

(2015) Ji Soo Lee et al.   Journal of Maternal-Fetal & Neonatal Medicine

Only humans have human placentas: molecular differences between mice and humans

(2015) André Schmidt et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

The role of invasive trophoblast in implantation and placentation of primates

(2015) A. M. Carter et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6

(2015) Shigenori Miura et al.   Nature Communications

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

(2015) Mirjana Kessler et al.   Nature Communications

Twenty years and still counting: including women as participants and studying sex and gender in biomedical research

(2015) Carolyn M. Mazure et al.   BMC Womens Health

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

The crucial role of mechanical heterogeneity in regulating follicle development and ovulation with engineered ovarian microtissue

(2014) Jung Kyu Choi et al.   BIOMATERIALS

Designing Drug Trials: Considerations for Pregnant Women

(2014) Jeanne S. Sheffield et al.   CLINICAL INFECTIOUS DISEASES

Microphysiological modeling of the reproductive tract: A fertile endeavor

(2014) Sharon L Eddie et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Effect of oxygen on multidrug resistance in term human placenta

(2014) M. Javam et al.   PLACENTA

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

(2014) Kasey Jividen et al.   Jove-Journal of Visualized Experiments

In Vitro Microvessel Growth and Remodeling within a Three-Dimensional Microfluidic Environment

(2013) Young K. Park et al.   Cellular and Molecular Bioengineering

Approach to Male Infertility and Induction of Spermatogenesis

(2013) Bradley D. Anawalt   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Maternal uterine NK cell–activating receptor KIR2DS1 enhances placentation

(2013) Shiqiu Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Clear castable polyurethane elastomer for fabrication of microfluidic devices

(2013) Karel Domansky et al.   LAB ON A CHIP

Three-dimensional systems for in vitro follicular culture: overview of alginate-based matrices

(2013) Ivina R. Brito et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System

(2013) Jordan A. Whisler et al.   TISSUE ENGINEERING PART C-METHODS

Recreating the female reproductive tract in vitro using iPSC technology in a linked microfluidics environment

(2013) Monica M Laronda et al.   Stem Cell Research & Therapy

Co-cultured endometrial stromal cells and peritoneal mesothelial cells for an in vitro model of endometriosis

(2012) Zhenling Chen et al.   Integrative Biology

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Real time culture and analysis of embryo metabolism using a microfluidic device with deformation based actuation

(2012) Yun Seok Heo et al.   LAB ON A CHIP

Reactive deposition of nano-films in deep polymeric microcavities

(2012) Asif Riaz et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Primary culture and immortalization of human fallopian tube secretory epithelial cells

(2012) Alison M Karst et al.   Nature Protocols

Review: Transport across the placenta of mice and women

(2012) M.R. Dilworth et al.   PLACENTA

The Fetus as a Patient and the Ethics of Human Subjects Research: Response to Commentaries on “An Ethically Justified Framework for Clinical Investigation to Benefit Pregnant and Fetal Patients”

(2011) Laurence B. McCullough et al.   AMERICAN JOURNAL OF BIOETHICS

In Vitro Fertilization on a Single-Oocyte Positioning System Integrated with Motile Sperm Selection and Early Embryo Development

(2011) Rui Ma et al.   ANALYTICAL CHEMISTRY

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Researching the Relationships between Tissue Providers, Clinicians, and Stem Cell Scientists

(2011) Erica Haimes et al.   Cell Stem Cell

Analysis of ciliary beat frequency and ovum transport ability in the mouse oviduct

(2011) Dongbo Shi et al.   GENES TO CELLS

The endocrine and paracrine control of menstruation

(2011) Patrick Henriet et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In vitro production of functional sperm in cultured neonatal mouse testes

(2011) Takuya Sato et al.   NATURE

IFPA Award in Placentology Lecture: Molecular regulation of human trophoblast invasion

(2011) M. Knöfler et al.   PLACENTA

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

In vitro production of fertile sperm from murine spermatogonial stem cell lines

(2011) Takuya Sato et al.   Nature Communications

Dynamic microfunnel culture enhances mouse embryo development and pregnancy rates

(2010) Y.S. Heo et al.   HUMAN REPRODUCTION

On-Chip Single Embryo Coculture With Microporous-Membrane-Supported Endometrial Cells

(2010) H. Kimura et al.   IEEE TRANSACTIONS ON NANOBIOSCIENCE

Chorioamnionitis: a multiorgan disease of the fetus?

(2010) M Gantert et al.   Journal of Perinatology

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Cyclic olefin polymers: emerging materials for lab-on-a-chip applications

(2010) Pedro S. Nunes et al.   Microfluidics and Nanofluidics

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

Parylene-coating in PDMS microfluidic channels prevents the absorption of fluorescent dyes

(2010) Hirotaka Sasaki et al.   SENSORS AND ACTUATORS B-CHEMICAL

Aetiology and Pathogenesis of IUGR

(2009) Srividhya Sankaran et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Drug transporters in the human blood-placental barrier

(2009) Kirsi Vähäkangas et al.   BRITISH JOURNAL OF PHARMACOLOGY

A microfluidicin vitrocultivation system for mechanical stimulation of bovine embryos

(2009) Minseok S. Kim et al.   ELECTROPHORESIS

The optimal timing of an ultrasound scan to assess the location and viability of an early pregnancy

(2009) C. Bottomley et al.   HUMAN REPRODUCTION

In vitro grown human ovarian follicles from cancer patients support oocyte growth

(2009) Min Xu et al.   HUMAN REPRODUCTION

Biological implications of polydimethylsiloxane-based microfluidic cell culture

(2009) Keil J. Regehr et al.   LAB ON A CHIP

Effects of oviductal fluid on the development, quality, and gene expression of porcine blastocysts produced in vitro

(2009) Rhiannon E Lloyd et al.   REPRODUCTION

The anatomy of the normal placenta

(2008) B Huppertz   JOURNAL OF CLINICAL PATHOLOGY

Epidemiology and causes of preterm birth

(2008) Robert L Goldenberg et al.   LANCET

The biology of infertility: research advances and clinical challenges

(2008) Martin M Matzuk et al.   NATURE MEDICINE

The in vitro growth and maturation of follicles

(2008) H M Picton et al.   REPRODUCTION